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Chapter 44 - Liver Transplantation in Children: Post-Transplant Care

from Section V - Other Considerations and Issues in Pediatric Hepatology

Published online by Cambridge University Press:  19 January 2021

Frederick J. Suchy
Affiliation:
University of Colorado, Children’s Hospital Colorado, Aurora
Ronald J. Sokol
Affiliation:
University of Colorado, Children’s Hospital Colorado, Aurora
William F. Balistreri
Affiliation:
Cincinnati Children’s Hospital Medical Center, Cincinnati
Jorge A. Bezerra
Affiliation:
Cincinnati Children’s Hospital Medical Center, Cincinnati
Cara L. Mack
Affiliation:
University of Colorado, Children’s Hospital Colorado, Aurora
Benjamin L. Shneider
Affiliation:
Texas Children’s Hospital, Houston
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Summary

Management in the early postoperative period requires the coordinated efforts of the transplant team and the pediatric intensive care staff, and other key ancillary services, such as interventional radiology, nephrology and infectious diseases that are frequently involved in the management of these children. Patients with end-stage liver disease undergoing liver transplantation require meticulous medical care in the immediate postoperative period to assure adequate perfusion of the graft and avoid exacerbation of injury to other organ systems. Care should be guided by attention to the pretransplant physiologic state, which might include advanced portal hypertension and compromise to other organ systems, such as seen in hepatorenal or hepatopulmonary syndrome. Specifics of the transplant procedure including information regarding blood loss, challenging vascular anastomosis, and graft function following reperfusion are also essential considerations in the management plan.

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Publisher: Cambridge University Press
Print publication year: 2021

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References

Iinuma, Y, Senda, K, Fujihara, N, Saito, T, Takakura, S, Kudo, T, et al. Surgical site infection in living-donor liver transplant recipients: a prospective study. Transplantation 2004;78(5):704–9.Google Scholar
Kawecki, D, Chmura, A, Pacholczyk, M, Lagiewska, B, Adadynski, L, Wasiak, D, et al. Bacterial infections in the early period after liver transplantation: etiological agents and their susceptibility. Med Sci Monit 2009;15(12):CR62837.Google ScholarPubMed
Shepherd, RW, Turmelle, Y, Nadler, M, Lowell, JA, Narkewicz, MR, McDiarmid, SV, et al. Risk factors for rejection and infection in pediatric liver transplantation. Am J Transplant 2008;8(2):396403.CrossRefGoogle ScholarPubMed
Danziger-Isakov, L, Bucavalas, J. Current Prevention Strategies Against Cytomegalovirus in the Studies in Pediatric Liver Transplantation (SPLIT) Centers. AJT 2014;14(8):1908–11.Google Scholar
Urschel, S, Altamirano-Diaz, LA, West, LJ. Immunosuppression armamentarium in 2010: mechanistic and clinical considerations. Pediatr Clin North Am 2010;57(2):433–57.Google Scholar
Wiesner, RH, Demetris, AJ, Belle, SH, Seaberg, EC, Lake, JR, Zetterman, RK, et al. Acute hepatic allograft rejection: incidence, risk factors, and impact on outcome. Hepatology 1998;28(3):638–45.Google Scholar
Feng, S. Long-term management of immunosuppression after pediatric liver transplantation: is minimization or withdrawal desirable or possible or both? Curr Opin Organ Transplant 2008;13(5):506–12.CrossRefGoogle ScholarPubMed
Miloh, T, Barton, A, Wheeler, J, Pham, Y, Hewitt, W, Keegan, T, et al. Immunosuppression in pediatric liver transplant recipients: unique aspects. Liver Transpl 2017;23(2):244–56.Google Scholar
Alonso, EM, Piper, JB, Echols, G, Thistlethwaite, JR, Whitington, PF. Allograft rejection in pediatric recipients of living related liver transplants. Hepatology 1996;23(1):40–3.Google Scholar
Ng, VL, Alonso, EM, Bucuvalas, JC, Cohen, G, Limbers, CA, Varni, JW, et al. Health status of children alive 10 years after pediatric liver transplantation performed in the US and Canada: report of the studies of pediatric liver transplantation experience. J Pediatr 2012;160(5):820–6, e3.CrossRefGoogle ScholarPubMed
Ng, VL, Fecteau, A, Shepherd, R, Magee, J, Bucuvalas, J, Alonso, E, et al. Outcomes of 5-year survivors of pediatric liver transplantation: report on 461 children from a North American multicenter registry. Pediatrics 2008;122(6):e1128–35.Google Scholar
Ekong, UD, Bhagat, H, Alonso, EM. Once daily calcineurin inhibitor monotherapy in pediatric liver transplantation. Am J Transplant 2010;10(4):883–8.Google Scholar
Lin, HC, Melin-Aldana, H, Mohammad, S, Ekong, UD, Alonso, EM. Extended follow-up of pediatric liver transplantation patients receiving once daily calcineurin inhibitor. Pediatr Transplant 2015;19(7):709–15.Google Scholar
Feng, S, Bucuvalas, J. Tolerance after liver transplantation: Where are we? Liver Transpl 2017;23(12):1601–14.Google Scholar
Gladdy, RA, Richardson, SE, Davies, HD, Superina, RA. Candida infection in pediatric liver transplant recipients. Liver Transplant Surg 1999;5(1):1624.CrossRefGoogle ScholarPubMed
Nafady-Hego, H, Elgendy, H, Moghazy, WE, Fukuda, K, Uemoto, S. Pattern of bacterial and fungal infections in the first 3 months after pediatric living donor liver transplantation: an 11-year single-center experience. Liver Transpl 2011;17(8):976–84.CrossRefGoogle ScholarPubMed
McDiarmid, SV, Anand, R, Martz, K, Millis, MJ, Mazariegos, G. A multivariate analysis of pre-, peri-, and post-transplant factors affecting outcome after pediatric liver transplantation. Ann Surg. 2011, 254(1):145–54.CrossRefGoogle Scholar
Narkewicz, MR, Green, M, Dunn, S, Millis, M, McDiarmid, S, Mazariegos, G, et al. Decreasing incidence of symptomatic Epstein-Barr virus disease and posttransplant lymphoproliferative disorder in pediatric liver transplant recipients: report of the studies of pediatric liver transplantation experience. Liver Transpl 2013;19(7):730–40.CrossRefGoogle ScholarPubMed
Furuichi, M, Fukuda, A, Sakamoto, S, Kasahara, M, Miyairi, I. Characteristics and risk factors of late-onset bloodstream infection beyond 6 months after liver transplantation in children. J Pediatric Infect Dis Soc 2018;37(3):263–8.Google Scholar
Tran, L, Hebert, D, Dipchand, A, Fecteau, A, Richardson, S, Allen, U. Invasive pneumococcal disease in pediatric organ transplant recipients: a high-risk population. Pediatr Transplant 2005;9(2):183–6.Google Scholar
Ackermann, O, Branchereau, S, Franchi-Abella, S, Pariente, D, Chevret, L, Debray, D, et al. The long-term outcome of hepatic artery thrombosis after liver transplantation in children: role of urgent revascularization. Am J Transplant 2012;12(6):1496–503.CrossRefGoogle ScholarPubMed
Feng, S, Bucuvalas, JC, Demetris, AJ, Burrell, BE, Spain, KM, Kanaparthi, S, et al. Evidence of chronic allograft injury in liver biopsies from long-term pediatric recipients of liver transplants. Gastroenterology 2018;155(6):1838–51, e7.CrossRefGoogle ScholarPubMed
Becker, NS, Barshes, NR, Aloia, TA, Nguyen, T, Rojo, J, Rodriguez, JA, et al. Analysis of recent pediatric orthotopic liver transplantation outcomes indicates that allograft type is no longer a predictor of survivals. Liver Transplant 2008;14(8):1125–32.Google Scholar
Duffy, JP, Hong, JC, Farmer, DG, Ghobrial, RM, Yersiz, H, Hiatt, JR, et al. Vascular complications of orthotopic liver transplantation: experience in more than 4,200 patients. J Am Coll Surg 2009;208(5):896903.Google Scholar
Stringer, MD, Marshall, MM, Muiesan, P, Karani, JB, Kane, PA, Mieli-Vergani, G, et al. Survival and outcome after hepatic artery thrombosis complicating pediatric liver transplantation. J Pediatr Surg 2001;36(6):888–91.Google Scholar
Calinescu, AM, Karam, O, Wilde, JCH, Ansari, M, McLin, VA, Wildhaber, BE. International survey on anticoagulation and antiplatelet strategies after pediatric liver transplantation. Pediatr Transplant 2019;23(1):e13317.CrossRefGoogle ScholarPubMed
Mamone, G, Caruso, S, di Francesco, F, Miraglia, R, de Ville de Goyet, J. Unusual venous collateral pathways allow for reperfusion of the intrahepatic portal venous system in children with portal vein thrombosis after split liver transplantation: clinical relevance and management implications. Pediatr Transplant 2019;23(6):e13539.Google Scholar
Shibasaki, S, Taniguchi, M, Shimamura, T, Suzuki, T, Yamashita, K, Wakayama, K, et al. Risk factors for portal vein complications in pediatric living donor liver transplantation. Clin Transplant 2010;24(4):550–6.Google Scholar
McDiarmid, SV, Anand, R, Martz, K, Millis, MJ, Mazariegos, G. A multivariate analysis of pre-, peri-, and post-transplant factors affecting outcome after pediatric liver transplantation. Ann Surg 2011;254(1):145–54.CrossRefGoogle ScholarPubMed
Nacoti, M, Ruggeri, GM, Colombo, G, Bonanomi, E, Lussana, F. Thrombosis prophylaxis in pediatric liver transplantation: a systematic review. World J Hepatol 2018;10:752–60.Google Scholar
Perkins, JD. Percutaneous transhepatic balloon dilation for portal venous stenosis. Liver Transpl 2006;12(2):321–2.Google ScholarPubMed
de Ville de Goyet, J, Gibbs, P, Clapuyt, P, Reding, R, Sokal, EM, Otte, JB. Original extrahilar approach for hepatic portal revascularization and relief of extrahepatic portal hypertension related to later portal vein thrombosis after pediatric liver transplantation. Long term results. Transplantation 1996;62(1):71–5.Google Scholar
Sakamoto, S, Egawa, H, Kanazawa, H, Shibata, T, Miyagawa-Hayashino, A, Haga, H, et al. Hepatic venous outflow obstruction in pediatric living donor liver transplantation using left-sided lobe grafts: Kyoto University experience. Liver Transpl 2010;16(10):1207–14.Google Scholar
Sunku, B, Salvalaggio, PRO, Donaldson, JS, Rigsby, CK, Neighbors, K, Superina, RA, et al. Outcomes and risk factors for failure of radiologic treatment of biliary strictures in pediatric liver transplantation recipients. Liver Transplant 2006;12(5):821–6.Google Scholar
Anderson, CD, Turmelle, YP, Darcy, M, Shepherd, RW, Weymann, A, Nadler, M, et al. Biliary strictures in pediatric liver transplant recipients – early diagnosis and treatment results in excellent graft outcomes. Pediatr Transplant 2010;14(3):358–63.Google Scholar
Ayoub, WS, Esquivel, CO, Martin, P. Biliary complications following liver transplantation. Dig Dis Sci 2010;55(6):1540–6.Google Scholar
Laurence, JM, Sapisochin, G, DeAngelis, M, Seal, JB, Miserachs, MM, Marquez, M, et al. Biliary complications in pediatric liver transplantation: incidence and management over a decade. Liver Transpl 2015;21(8):1082–90.Google Scholar
Miraglia, R, Maruzzelli, L, Caruso, S, Riva, S, Spada, M, Luca, A, et al. Percutaneous management of biliary strictures after pediatric liver transplantation. J Vasc Interv Radiol 2008;31(5):993–8.Google ScholarPubMed
Kerkar, N, Vergani, D. De novo autoimmune hepatitis -is this different in adults compared to children? J Autoimmun 2018;95:2633.Google Scholar
Hubscher, S. What does the long-term liver allograft look like for the pediatric recipient? Liver Transpl 2009;15(Suppl. 2):S1924.Google Scholar
Avitzur, Y, Ngan, BY, Lao, M, Fecteau, A, Ng, VL. Prospective evaluation of the prevalence and clinical significance of positive autoantibodies after pediatric liver transplantation. J Pediatr Gastroenterol Nutr 2007;45(2):222–7.Google Scholar
Arterbery, AS, Yao, J, Ling, A, Avitzur, Y, Martinez, M, Lobritto, S, et al. Inflammasome priming mediated via toll-like receptors 2 and 4, induces Th1-like regulatory T cells in de novo autoimmune hepatitis. Front Immunol 2018;9:1612.Google Scholar
Demetris, AJ, Bellamy, C, Hubscher, SG, O’Leary, J, Randhawa, PS, Feng, S, et al. 2016 Comprehensive Update of the Banff Working Group on Liver Allograft Pathology: Introduction of Antibody-Mediated Rejection. Am J Transplant 2016;16(10):2816–35.Google Scholar
Yoeli, D, Ackah, RL, Sigireddi, RR, Kueht, ML, Galvan, NTN, Cotton, RT, et al. Reoperative complications following pediatric liver transplantation. J Pediatr Surg 2018;53(11):2240–4.CrossRefGoogle ScholarPubMed
Soltys, KA, Mazariegos, GV, Squires, RH, Sindhi, RK, Anand, R, Group, SR. Late graft loss or death in pediatric liver transplantation: an analysis of the SPLIT database. Am J Transplant 2007;7(9):2165–71.Google Scholar
Ng, V, Anand, R, Martz, K, Fecteau, A. Liver retransplantation in children: a SPLIT database analysis of outcome and predictive factors for survival. Am J Transplant 2008;8(2):386–95.CrossRefGoogle ScholarPubMed
McLin, VA, Anand, R, Daniels, SR, Yin, W, Alonso, EM, Group, SR. Blood pressure elevation in long-term survivors of pediatric liver transplantation. Am J Transplant 2012;12(1):183–90.Google Scholar
Campbell, KM, Bucuvalas, JC. Renal function in the long term after pediatric liver transplantation: is there a need for protocol kidney biopsies? Curr Opin Organ Transplant 2010;15(5):608–13.Google Scholar
Maes, M, Sokal, E, Otte, J. Growth factors in children with end-stage liver disease before and after liver transplantation: a review. Pediatr Transplant 1997;1:171–5.Google Scholar
Sarna, S, Laine, J, Sipila, I, Koistinen, R, Holmberg, C. Differences in linear growth and cortisol production between liver and renal transplant recipients on similar immunosuppression. Transplantation 1995;60(7):656–61.CrossRefGoogle ScholarPubMed
Alonso, EM, Shepherd, R, Martz, KL, Yin, W, Anand, R, Group, SR. Linear growth patterns in prepubertal children following liver transplantation. Am J Transplant 2009;9(6):1389–97.CrossRefGoogle ScholarPubMed
Reding, R. Steroid withdrawal in liver transplantation: benefits, risks, and unanswered questions. Transplantation 2000;70(3):405–10.Google Scholar
Sarna, S, Sipila, I, Ronnholm, K, Koistinen, R, Holmberg, C. Recombinant human growth hormone improves growth in children receiving glucocorticoid treatment after liver transplantation. Int J Clin Endocrinol Metab 1996;81(4):1476–82.Google Scholar
Puustinen, L, Jalanko, H, Holmberg, C, Merenmies, J. Recombinant human growth hormone treatment after liver transplantation in childhood: the 5-year outcome. Transplantation 2005;79(9):1241–6.Google Scholar
Scheenstra, R, Gerver, WJ, Odink, RJ, van Soest, H, Peeters, PM, Verkade, HJ, et al. Growth and final height after liver transplantation during childhood. J Pediatr Gastroenterol Nutr 2008;47(2):165–71.CrossRefGoogle ScholarPubMed
Quiros-Tejeira, RE, Ament, ME, Heyman, MB, Martin, MG, Rosenthal, P, Gornbein, JA, et al. Does liver transplantation affect growth pattern in Alagille syndrome? Liver Transpl 2000;6(5):582–7.Google Scholar
Campeau, PM, Pivalizza, PJ, Miller, G, McBride, K, Karpen, S, Goss, J, et al. Early orthotopic liver transplantation in urea cycle defects: follow-up of a developmental outcome study. Mol Genet Metab 2010;100(Suppl. 1):S84–7.Google Scholar
Ng, VL, Sorensen, LG, Alonso, EM, Fredericks, EM, Ye, W, Moore, J, et al. Neurodevelopmental Outcome of Young Children with Biliary Atresia and Native Liver: Results from the ChiLDReN Study. J Pediatr 2018;196:139–47, e3.CrossRefGoogle ScholarPubMed
Wayman, KI, Cox, KL, Esquivel, CO. Neurodevelopmental outcome of young children with extrahepatic biliary atresia 1 year after liver transplantation. J Pediatr 1997;131(6):894–8.CrossRefGoogle ScholarPubMed
Gilmour, S, Adkins, R, Liddell, GA, Jhangri, G, Robertson, CM. Assessment of psychoeducational outcomes after pediatric liver transplant. Am J Transplant 2009;9(2):294300.CrossRefGoogle ScholarPubMed
Gilmour, S, Sorenson, L, Anand, R, Yin, W, Alonso, E. School outcomes in children registered in the Studies of Pediatric Liver Transplantation (SPLIT) consortium. Liver Transpl 2010;16(9):1041–8.CrossRefGoogle ScholarPubMed
Krull, K, Fuchs, C, Yurk, H, Boone, P, Alonso, E. Neurocognitive outcome in pediatric liver transplant recipients. Pediatr Transplant 2003;7(2):111–18.Google Scholar
Sorensen, LG, Neighbors, K, Martz, K, Zelko, F, Bucuvalas, JC, Alonso, EM. Longitudinal study of cognitive and academic outcomes after pediatric liver transplantation.J Pediatr 2014;165(1):6572, e2.Google Scholar
Bucuvalas, JC, O’Connor, A, Buschle, K, Krug, S, Ryckman, FC, Atherton, H, et al. Risk of hearing impairment in pediatric liver transplant recipients: a single center study. Pediatr Transplant 2003;7(4):265–9.Google Scholar
Ohnemus, D, Neighbors, K, Rychlik, K, Venick, RS, Bucuvalas, JC, Sundaram, SS, et al. Health-related quality of life and cognitive functioning in pediatric liver transplant recipients. Liver Transpl 2020;26(1):4556.CrossRefGoogle ScholarPubMed
Alonso, EM, Limbers, C, Neighbors, K, Martz, K, Bucuvalas, JC, Webb, T, et al. Cross-sectional analysis of health-related quality of life in pediatric liver transplant recipients. J Pediatr 2010;156:270–6.Google Scholar
Cole, CR, Bucuvalas, JC, Hornung, RW, Krug, S, Ryckman, FC, Atherton, H, et al. Impact of liver transplantation on HRQOL in children less than 5 years old. Pediatr Transplant 2004;8(3):222–7.Google Scholar
Parmar, A, Vandriel, SM, Ng, VL. Health-related quality of life after pediatric liver transplantation: a systematic review. Liver Transpl 2017;23(3):361–74.Google Scholar
Sundaram, SS, Landgraf, JM, Neighbors, K, Cohn, RA, Alonso, EM. Adolescent health-related quality of life following liver and kidney transplantation. Am J Transplant 2007;7(4):982–9.Google Scholar
Mintzer, LL, Stuber, ML, Seacord, D, Castaneda, M, Mesrkhani, V, Glover, D. Traumatic stress symptoms in adolescent organ transplant recipients. Pediatrics 2005;115(6):1640–4.Google Scholar
Alonso, EM, Neighbors, K, Mattson, C, Sweet, E, Ruch-Ross, H, Berry, C, et al. Functional outcomes of pediatric liver transplantation. J Pediatr Gastroenterol Nutr 2003;37(2):155–60.Google Scholar
Young, GS, Mintzer, LL, Seacord, D, Castaneda, M, Mesrkhani, V, Stuber, ML. Symptoms of posttraumatic stress disorder in parents of transplant recipients: incidence, severity, and related factors. Pediatrics 2003;111(6 Pt 1):e725–31.Google Scholar

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