Processing, storing, and communicating information that originates as an analog phenomenon involve conversion of the information to bits. This conversion can be described by the combined effect of sampling and quantization. The digital representation in this procedure is achieved by first sampling the analog signal so as to represent it by a set of discrete-time samples and then quantizing these samples to a finite number of bits. Traditionally, these two operations are considered separately. The sampler is designed to minimize information loss due to sampling based on prior assumptions about the continuous-time input. The quantizer is designed to represent the samples as accurately as possible, subject to the constraint on the number of bits that can be used in the representation. The goal of this chapter is to revisit this paradigm by considering the joint effect of these two operations and to illuminate the dependence between them.