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Chapter 1 - Women's Health Initiative Memory Study (WHIMS) program: emerging findings

from Section 1 - Estrogens and cognition: perspectives and opportunities in the wake of the Women's Health Initiative Memory Study

Published online by Cambridge University Press:  06 July 2010

By
Mark A. Espeland ,
Sally A. Shumaker ,
Patricia E. Hogan  and
Susan M. Resnick
Edited by
Eef Hogervorst ,
Victor W. Henderson ,
Robert B. Gibbs  and
Roberta Diaz Brinton
Eef Hogervorst
Affiliation:
Loughborough University
Victor W. Henderson
Affiliation:
Stanford University, California
Robert B. Gibbs
Affiliation:
University of Pittsburgh
Roberta Diaz Brinton
Affiliation:
University of Southern California
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Summary

The landmark women's health initiative memory study (WHIMS) program has had an enormous impact on understanding of how estrogens and estrogen-containing hormone therapy affect cognitive outcomes in postmenopausal women. This chapter focuses on the impact of hormone therapy on cognition in older women. It summarizes the primary findings of the women's health initiative (WHI) on cardiovascular disease. The WHIMS also found a small adverse effect of assignment to hormone therapy on global cognitive function, as measured by modified mini-mental state (3MS) examinations. The Women's Health Initiative Study of cognitive aging (WHISCA) was designed to examine the impact of conjugated equine estrogens (CEE)-based therapy on longitudinal changes of cognitive tests targeting several different domains. The women's health initiative memory study of magnetic resonance imaging (WHIMS-MRI) was designed to contrast neuroradiologic outcomes among women who had been assigned to active versus placebo therapy during the WHIMS trials.
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Chapter
Information
Hormones, Cognition and Dementia
State of the Art and Emergent Therapeutic Strategies
 , pp. 1 - 10
Publisher: Cambridge University Press
Print publication year: 2009

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