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17 - Psychoneuroimmunology

from Systemic Psychophysiology

Published online by Cambridge University Press:  27 January 2017

By
Michael R. Irwin  and
George M. Slavich
Edited by
John T. Cacioppo ,
Louis G. Tassinary  and
Gary G. Berntson
John T. Cacioppo
Affiliation:
University of Chicago
Louis G. Tassinary
Affiliation:
Texas A & M University
Gary G. Berntson
Affiliation:
Ohio State University
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Handbook of Psychophysiology , pp. 377 - 398
Publisher: Cambridge University Press
Print publication year: 2016

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References

Amit, I., Garber, M., Chevrier, N., Leite, A. P., Donner, Y., Eisenhaure, T., … & Regev, A. (2009). Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses. Science, 326: 257–263.Google Scholar
Antoni, M. H. (2013). Psychosocial intervention effects on adaptation, disease course and biobehavioral processes in cancer. Brain, Behavior, and Immunity, 30: S88–S98.Google Scholar
Aschbacher, K., Epel, E., Wolkowitz, O. M., Prather, A. A., Puterman, E., & Dhabhar, F. S. (2012). Maintenance of a positive outlook during acute stress protects against pro-inflammatory reactivity and future depressive symptoms. Brain, Behavior, and Immunity, 26: 346–352.Google Scholar
Avitsur, R., Kinsey, S. G., Bidor, K., Bailey, M. T., Padgett, D. A., & Sheridan, J. F. (2007). Subordinate social status modulates the vulnerability to the immunological effects of social stress. Psychoneuroendocrinology, 32: 1097–1105.Google Scholar
Barton, G. M. (2008). A calculated response: control of inflammation by the innate immune system. Journal of Clinical Investigation, 118: 413–420.CrossRefGoogle Scholar
Benedetti, F., Lucca, A., Brambilla, F., Colombo, C., & Smeraldi, E. (2002). Interleukine-6 serum levels correlate with response to antidepressant sleep deprivation and sleep phase advance. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 26: 1167–1170.Google Scholar
Berkenbosch, F., van Oers, J., del Rey, A., Tilders, F., & Besedovsky, H. (1987). Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1. Science, 238: 524–526.Google Scholar
Besedovsky, H., del Rey, A., Sorkin, E., & Dinarello, C. A. (1986). Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science, 233: 52–54.Google Scholar
Bierhaus, A., Wolf, J., Andrassy, M., Rohleder, N., Humpert, P. M., Petrov, D., … & Nawroth, P. P. (2003). A mechanism converting psychosocial stress into mononuclear cell activation. Proceedings of the National Academy of Sciences of the USA, 100: 1920–1925.Google Scholar
Bower, J. E., Ganz, P. A., Aziz, N., Olmstead, R., Irwin, M. R., & Cole, S. W. (2007). Inflammatory responses to psychological stress in fatigued breast cancer survivors: relationship to glucocorticoids. Brain, Behavior and Immunity, 21: 251–258.CrossRefGoogle ScholarPubMed
Bower, J. E. & Irwin, M. R. (2016). Mind–body therapies and control of inflammatory biology: a descriptive review. Brain, Behavior, and Immunity, 51: 1–11.CrossRefGoogle ScholarPubMed
Breen, E. C., Rezai, A. I., Nakajima, K., Beall, G. N., Mitsuyasu, R. T., Hirano, T., … & Martinez-Maza, O. (1990). Infection with HIV is associated with elevated IL-6 levels and production. Journal of Immunology, 144: 480–484.CrossRefGoogle ScholarPubMed
Brown, R., Pang, G., Husband, A. J., & King, M. G. (1989). Suppression of immunity to influenza virus infection in the respiratory tract following sleep disturbance. Regional Immunology, 2: 321–325.Google ScholarPubMed
Bull, S. J., Huezo-Diaz, P., Binder, E. B., Cubells, J. F., Ranjith, G., Maddock, G., … & Pariante, C. M. (2009). Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-alpha and ribavirin treatment. Molecular Psychiatry, 14: 1095–1104.Google Scholar
Cappuccio, F. P., D’Elia, L., Strazzullo, P., & Miller, M. A. (2010). Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies. Sleep, 33: 585–592.Google Scholar
Carroll, J. E., Low, C. A., Prather, A. A., Cohen, S., Fury, J. M., Ross, D. C., & Marsland, A. L. (2011). Negative affective responses to a speech task predict changes in interleukin (IL)-6. Brain, Behavior, and Immunity, 25: 232–238.Google Scholar
Chen, E., Miller, G. E., Walker, H. A., Arevalo, J. M., Sung, C. Y., & Cole, S. W. (2009). Genome-wide transcriptional profiling linked to social class in asthma. Thorax, 64: 38–43.Google Scholar
Cohen, S., Doyle, W. J., Alper, C. M., Janicki-Deverts, D., & Turner, R. B. (2009). Sleep habits and susceptibility to the common cold. Archives of Internal Medicine, 169: 62–67.Google Scholar
Cohen, S., Janicki-Deverts, D., & Miller, G. E. (2007). Psychological stress and disease. Journal of the American Medical Association, 298: 1685–1687.Google Scholar
Cohen, S., Tyrrell, D. A. J., & Smith, A. P. (1991). Psychological stress and susceptibility to the common cold. New England Journal of Medicine, 325: 606–612.Google Scholar
Cole, S. W. (2009). Chronic inflammation and breast cancer recurrence. Journal of Clinical Oncology, 27: 3418–3419.Google Scholar
Cole, S. W., Arevalo, J. M., Manu, K., Telzer, E. H., Kiang, L., Bower, J. E., … & Fuligni, A. J. (2011a). Antagonistic pleiotropy at the human IL6 promoter confers genetic resilience to the pro-inflammatory effects of adverse social conditions in adolescence. Developmental Psychology, 47: 1173–1180.Google Scholar
Cole, S. W., Arevalo, J. M., Takahashi, R., Sloan, E. K., Lutgendorf, S. K., Sood, A. K., … & Seeman, T. E. (2010). Computational identification of gene–social environment interaction at the human IL6 locus. Proceedings of the National Academy of Sciences of the USA, 107: 5681–5686.Google Scholar
Cole, S. W., Hawkley, L. C., Arevalo, J. M., & Cacioppo, J. T. (2011b). Transcript origin analysis identifies antigen-presenting cells as primary targets of socially regulated gene expression in leukocytes. Proceedings of the National Academy of Sciences of the USA, 108: 3080–3085.Google Scholar
Cole, S. W., Hawkley, L. C., Arevalo, J. M., Sung, C. Y., Rose, R. M., & Cacioppo, J. T. (2007). Social regulation of gene expression in human leukocytes. Genome Biology, 8: 1–13.Google Scholar
Cole, S. W. & Kemeny, M. E. (1997). Psychobiology of HIV infection. Critical Reviews in Neurobiology, 11: 289–321.Google Scholar
Cole, S. W., Kemeny, M. E., & Taylor, S. E. (1997). Social identity and physical health: accelerated HIV progression in rejection-sensitive gay men. Journal of Personality and Social Psychology, 72: 320–335.CrossRefGoogle ScholarPubMed
Cole, S. W., Korin, Y. D., Fahey, J. L., & Zack, J. A. (1998). Norepinephrine accelerates HIV replication via protein kinase A-dependent effects on cytokine production. Journal of Immunology, 161: 610–616.Google Scholar
Collado-Hidalgo, A., Bower, J. E., Ganz, P. A., Irwin, M. R., & Cole, S. W. (2008). Cytokine gene polymorphisms and fatigue in breast cancer survivors: early findings. Brain, Behavior and Immunology, 22: 1197–1200.Google Scholar
Collado-Hidalgo, A., Sung, C., & Cole, S. (2006). Adrenergic inhibition of innate anti-viral response: PKA blockade of Type I interferon gene transcription mediates catecholamine support for HIV-1 replication. Brain, Behavior and Immunology, 20: 552–563.Google Scholar
Creswell, J. D., Irwin, M. R., Burklund, L. J., Lieberman, M. D., Arevalo, J. M., Ma, J., … & Cole, S. W. (2012). Mindfulness-based stress reduction training reduces loneliness and pro-inflammatory gene expression in older adults: a small randomized controlled trial. Brain, Behavior and Immunology, 26: 1095–1101.CrossRefGoogle ScholarPubMed
Curfs, J. H., Meis, J. F., & Hoogkamp-Korstanje, J. A. (1997). A primer on cytokines: sources, receptors, effects, and inducers. Clinical Microbiology Reviews, 10: 742–780.Google Scholar
Danese, A., Moffitt, T. E., Pariante, C. M., Ambler, A., Poulton, R., & Caspi, A. (2008). Elevated inflammation levels in depressed adults with a history of childhood maltreatment. Archives of Generaal Psychiatry, 65: 409–415.Google Scholar
Dantzer, R., O’Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008). From inflammation to sickness and depression: when the immune system subjugates the brain. Nature Reviews Neuroscience, 9: 46–56.Google Scholar
Davis, M. C., Zautra, A. J., Younger, J., Motivala, S. J., Attrep, J., & Irwin, M. R. (2008). Chronic stress and regulation of cellular markers of inflammation in rheumatoid arthritis. Brain, Behavior, and Immunity, 22: 24–32.Google Scholar
DellaGioia, N. & Hannestad, J. (2010). A critical review of human endotoxin administration as an experimental paradigm of depression. Neuroscience & Biobehavioral Reviews, 34: 130–143.Google Scholar
Dew, M. A., Hoch, C. C., Buysse, D. J., Monk, T. H., Begley, A. E., Houck, P. R., … & Reynolds, C. F. III (2003). Healthy older adults’ sleep predicts all-cause mortality at 4 to 19 years of follow-up. Psychosomatic Medicine, 65: 63–73.Google Scholar
Dhabhar, F. S., Malarkey, W. B., Neri, E., & McEwen, B. S. (2012). Stress-induced redistribution of immune cells–from barracks to boulevards to battlefields: a tale of three hormones – Curt Richter Award winner. Psychoneuroendocrinology, 37: 1345–1368.Google Scholar
Dickerson, S. S., Gable, S. L., Irwin, M. R., Aziz, N., & Kemeny, M. E. (2009). Social-evaluative threat and proinflammatory cytokine regulation: an experimental laboratory investigation. Psychological Science, 20: 1237–1244.Google Scholar
Dickerson, S. S. & Kemeny, M. E. (2004). Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Psychological Bulletin, 130: 355–391.Google Scholar
Dickerson, S. S., Kemeny, M. E., Aziz, N., Kim, K. H., & Fahey, J. L. (2004). Immunological effects of induced shame and guilt. Psychosomtic Medicine, 66: 124–131.Google Scholar
Edwards, K. M., Burns, V. E., Reynolds, T., Carroll, D., Drayson, M., & Ring, C. (2006). Acute stress exposure prior to influenza vaccination enhances antibody response in women. Brain, Behavior, and Immunology, 20: 159–168.Google Scholar
Eisenberger, N. I., Berkman, E. T., Inagaki, T. K., Rameson, L. T., Mashal, N. M., & Irwin, M. R. (2010a). Inflammation-induced anhedonia: endotoxin reduces ventral striatum responses to reward. Biological Psychiatry, 68: 748–754.CrossRefGoogle ScholarPubMed
Eisenberger, N. I., Inagaki, T. K., Mashal, N. M., & Irwin, M. R. (2010b). Inflammation and social experience: an inflammatory challenge induces feelings of social disconnection in addition to depressed mood. Brain, Behavior, and Immunity, 24: 558–563.Google Scholar
Eisenberger, N. I., Inagaki, T. K., Rameson, L. T., Mashal, N. M., & Irwin, M. R. (2009). An fMRI study of cytokine-induced depressed mood and social pain: the role of sex differences. NeuroImage, 47: 881–890.Google Scholar
Engler, H., Bailey, M. T., Engler, A., & Sheridan, J. F. (2004). Effects of repeated social stress on leukocyte distribution in bone marrow, peripheral blood and spleen. Journal of Neuroimmunology, 148: 106–115.Google Scholar
Frank, M. G., Hendricks, S. E., Johnson, D., & Burke, W. J. (1999). Antidepressants augment natural killer cell activity: in vivo and in vitro. Neuropsychobiology, 39: 18–24.CrossRefGoogle ScholarPubMed
Friedman, E. M. & Irwin, M. (1997). Modulation of immune cell function by the autonomic nervous system. Pharmacology Therapy, 74: 27–38.Google Scholar
Fuligni, A. J., Telzer, E. H., Bower, J., Cole, S. W., Kiang, L., & Irwin, M. R. (2009a). A preliminary study of daily interpersonal stress and C-reactive protein levels among adolescents from Latin American and European backgrounds. Psychosomatic Medicine, 71 (3): 329–33.Google Scholar
Fuligni, A. J., Telzer, E. H., Bower, J., Irwin, M. R., Kiang, L., & Cole, S. W. (2009b). Daily family assistance and inflammation among adolescents from Latin American and European backgrounds. Brain, Behavior, and Immunity, 23: 803–809.Google Scholar
Gimeno, D., Kivimäki, M., Brunner, E. J., Elovainio, M., De Vogli, R., Steptoe, A., … & Ferrie, J. E. (2009). Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study. Psychological Medicine, 39: 413–423.Google Scholar
Glaser, R. & Kiecolt-Glaser, J. K. (2005). Stress-induced immune dysfunction: implications for health. Nature Reviews Immunology, 5: 243–251.Google Scholar
Goebel, M. U., Mills, P. J., Irwin, M. R., & Ziegler, M. G. (2000). Interleukin-6 and tumor necrosis factor-alpha production after acute psychological stress, exercise, and infused isoproterenol: differential effects and pathways. Psychosomatic Medicine, 62: 591–598.CrossRefGoogle ScholarPubMed
Grebe, K. M., Takeda, K., Hickman, H. D., Bailey, A. L., Embry, A. C., Bennink, J. R., & Yewdell, J. W. (2009). Cutting edge: sympathetic nervous system increases proinflammatory cytokines and exacerbates influenza A virus pathogenesis. Journal of Immunology, 184: 540–544.Google Scholar
Gruys, E., Toussaint, M. J. M., Niewold, T. A., & Koopmans, S. J. (2005). Acute phase reaction and acute phase proteins. Journal of Zhejiang University Science B, 6: 1045–1056.Google Scholar
Haack, M., Sanchez, E., & Mullington, J. M. (2007). Elevated inflammatory markers in response to prolonged sleep restriction are associated with increased pain experience in healthy volunteers. Sleep, 30: 1145–1152.Google Scholar
Harrison, N. A., Brydon, L., Walker, C., Gray, M. A., Steptoe, A., & Critchley, H. D. (2009). Inflammation causes mood changes through alterations in subgenual cingulate activity and mesolimbic connectivity. Biological Psychiatry, 66: 407–414.Google Scholar
Hart, B. L. (1988). Biological basis of the behavior of sick animals. Neuroscience & Biobehavioral Reviews, 12: 123–137.Google Scholar
Howren, M. B., Lamkin, D. M., & Suls, J. (2009). Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosomatic Medicine, 71: 171–186.Google Scholar
Hubbard, A. K. & Rothlein, R. (2000). Intercellular adhesion molecule-1 (ICAM-1) expression and cell signaling cascades. Free Radical Biology & Medicine, 28: 1379–1386.Google Scholar
Imeri, L. & Opp, M. R. (2009). How (and why) the immune system makes us sleep. Nature Reviews Neuroscience, 10: 199–210.Google Scholar
Irwin, M. R. (2015). Why sleep is important for health: a psychoneuroimmunology perspective. Annual Review of Psychology, 66: 2.1–2.30.CrossRefGoogle Scholar
Irwin, M. R., Carrillo, C., & Olmstead, R. (2010). Sleep loss activates cellular markers of inflammation: sex differences. Brain, Behavior, and Immunity, 24: 54–57.Google Scholar
Irwin, M. R. & Cole, S. W. (2011). Reciprocal regulation of the neural and innate immune systems. Nature Reviews Immunology, 11: 625–632.Google Scholar
Irwin, M. R., Costlow, C., Williams, H., Artin, K. H., Chan, C. Y., Stinson, D. L., … & Oxman, M. N. (1998). Cellular immunity to varicella-zoster virus in patients with major depression. Journal of Infectious Diseases, 178: S104–S108.Google Scholar
Irwin, M. R., Lacher, U., & Caldwell, C. (1992). Depression and reduced natural killer cytotoxicity: a longitudinal study of depressed patients and control subjects. Psychological Medicine, 22: 1045–1050.Google Scholar
Irwin, M. R., Levin, M. J., Carrillo, C., Olmstead, R., Lucko, A., Lang, N., … & Oxman, M. N. (2011). Major depressive disorder and immunity to varicella-zoster virus in the elderly. Brain, Behavior, and Immunity, 25: 759–766.Google Scholar
Irwin, M. R., Levin, M. J., Laudenslager, M. L., Olmstead, R., Lucko, A., Lang, N., … & Oxman, M. N. (2013). Varicella zoster virus-specific immune responses to a herpes zoster vaccine in elderly recipients with major depression and the impact of antidepressant medications. Clinical Infectious Diseases, 56: 1085–1093.Google Scholar
Irwin, M. R., McClintick, J., Costlow, C., Fortner, M., White, J., & Gillin, J. C. (1996). Partial night sleep deprivation reduces natural killer and cellular immune responses in humans. FASEB Journal, 10: 643–653.CrossRefGoogle ScholarPubMed
Irwin, M. R. & Miller, A. H. (2007). Depressive disorders and immunity: 20 years of progress and discovery. Brain, Behavior, and Immunity, 21: 374–383.CrossRefGoogle ScholarPubMed
Irwin, M. R., Olmstead, R., Breen, E. C., Witarama, T., Carrillo, C., Sadeghi, N., … & Cole, S. (2014b). Tai Chi, cellular inflammation, and transcriptome dynamics in breast cancer survivors with insomnia: a randomized controlled trial. Journal of the National Cancer Institute, 50: 295–301.Google Scholar
Irwin, M. R., Olmstead, R., Breen, E. C., Witarama, T., Carrillo, C., Sadeghi, N., … & Cole, S. (2015). Cognitive behavioral therapy and Tai Chi reverse cellular and genomic markers of inflammation in late life insomnia: a randomized controlled trial. Biological Psychiatry, 78: 721–729.Google Scholar
Irwin, M. R., Olmstead, R., Carrillo, C., Sadeghi, N., Breen, E. C., Witarama, T., … & Nicassio, P. (2014a). Cognitive behavioral therapy vs. Tai Chi for late life insomnia and inflammatory risk: a randomized controlled comparative efficacy trial. Sleep, 37: 1543–1552.Google Scholar
Irwin, M. R., Olmstead, R., Carrillo, C., Sadeghi, N., Fitzgerald, J. D., Ranganath, V. K., & Nicassio, P. M. (2012). Sleep loss exacerbates fatigue, depression, and pain in rheumatoid arthritis. Sleep, 35: 537–543.Google Scholar
Irwin, M. R., Olmstead, R., & Carroll, J. E. (2016). Sleep disturbance, sleep duration, and inflammation: a systematic review and meta-analysis of cohort studies and experimental sleep deprivation. Biological Psychiatry, 80: 40–52.CrossRefGoogle ScholarPubMed
Irwin, M. R., Olmstead, R., & Oxman, M. N. (2007). Augmenting immune responses to varicella zoster virus in older adults: a randomized, controlled trial of Tai Chi. Journal of the American Geriatrics Society, 55: 511–517.Google Scholar
Irwin, M. R., Olmstead, R., Valladares, E. M., Breen, E. C., & Ehlers, C. L. (2009). Tumor necrosis factor antagonism normalizes rapid eye movement sleep in alcohol dependence. Biological Psychiatry, 66: 191–195.Google Scholar
Irwin, M. R., Thompson, J., Miller, C., Gillin, J. C., & Ziegler, M. (1999). Effects of sleep and sleep deprivation on catecholamine and interleukin-2 levels in humans: clinical implications. Journal of Clinical Endocrinology and Metabolism, 84: 1979–1985.Google Scholar
Irwin, M. R., Wang, M., Campomayor, C. O., Collado-Hidalgo, A., & Cole, S. (2006). Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation. Archives of Internal Medicine, 166: 1756–1762.Google Scholar
Irwin, M. R., Wang, M., Ribeiro, D., Cho, H. J., Olmstead, R., Breen, E. C., … & Cole, S. (2008). Sleep loss activates cellular inflammatory signaling. Biological Psychiatry, 64: 538–540.Google Scholar
Jarcho, M. R., Slavich, G. M., Tylova-Stein, H., Wolkowitz, O. M., & Burke, H. M. (2013). Dysregulated diurnal cortisol pattern is associated with glucocorticoid resistance in women with major depressive disorder. Biological Psychology, 93: 150–158.Google Scholar
Karin, M. (2006). Nuclear factor-kappaB in cancer development and progression. Nature, 441: 431–436.Google Scholar
Kiecolt-Glaser, J. K., Bennett, J. M., Andridge, R., Peng, J., Shapiro, C. L., Malarkey, W. B., … & Glaser, R. (2014). Yoga’s impact on inflammation, mood, and fatigue in breast cancer survivors: a randomized controlled trial. Journal of Clinical Oncology, 32: 1040–1049.Google Scholar
Kiecolt-Glaser, J. K., Glaser, R., Gravenstein, S., Malarkey, W. B., & Sheridan, J. (1996). Chronic stress alters the immune response to influenza virus vaccine in older adults. Proceedings of the National Academy of Sciences of the USA, 93: 3043–3047.Google Scholar
Kiecolt-Glaser, J. K., Loving, T. J., Stowell, J. R., Malarkey, W. B., Lemeshow, S., Dickinson, S. L., & Glaser, R. (2005). Hostile marital interactions, proinflammatory cytokine production, and wound healing. Archives of General Psychiatry, 62: 1377–1384.Google Scholar
Kiecolt-Glaser, J. K., Preacher, K. J., MacCallum, R. C., Atkinson, C., Malarkey, W. B., & Glaser, R. (2003). Chronic stress and age-related increases in the proinflammatory cytokine IL-6. Proceedings of the National Academy of Sciences of the USA, 100: 9090–9095.Google Scholar
Kubera, M., Symbirtsev, A., Basta-Kaim, A., Borycz, J., Roman, A. Papp, M., & Claesson, M. (1996). Effect of chronic treatment with imipramine on interleukin-1 and interleukin-2 production by splenocytes obtained from rats subjected to a chronic mild stress model of depression. Polish Journal of Pharmacology, 48: 503–506.Google ScholarPubMed
Lange, T., Dimitrov, S., Bollinger, T., Diekelmann, S., & Born, J. (2011). Sleep after vaccination boosts immunological memory. Journal of Immunology, 187: 283–290.Google Scholar
Lange, T., Perras, B., Fehm, H. L., & Born, J. (2003). Sleep enhances the human antibody response to hepatitis A vaccination. Psychosomatic Medicine, 65: 831–835.Google Scholar
Lee, H. J., Takemoto, N., Kurata, H., Kamogawa, Y., Miyatake, S., O’Garra, A., & Arai, N. (2000). GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells. Journal of Experimental Medicine, 192: 105–115.Google Scholar
Lotrich, F. E., El-Gabalawi, H., Guenther, L. C., & Ware, C. F. (2011). The role of inflammation in the pathophysiology of depression: different treatments and their effects. Journal of Rheumatology, 88: 48–54.Google Scholar
Mangge, H., Kenzian, H., Gallistl, S., Neuwirth, G., Liebmann, P., Kaulfersch, W., … & Schauenstein, K. (1995). Serum cytokines in juvenile rheumatoid arthritis: correlation with conventional inflammation parameters and clinical subtypes. Arthritis and Rheumatism, 38: 211–220.Google Scholar
Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008). Cancer-related inflammation. Nature, 454: 436–444.Google Scholar
Matthews, K. A., Schott, L. L., Bromberger, J. T., Cyranowski, J. M., Everson-Rose, S. A., & Sowers, M. (2010). Are there bi-directional associations between depressive symptoms and C-reactive protein in mid-life women? Brain, Behavior, and Immunity, 24: 96–101.Google Scholar
Matzinger, P. (2007). Friendly and dangerous signals: is the tissue in control? Nature Immunology, 8: 11–3.Google Scholar
Mays, J. W., Bailey, M. T., Hunzeker, J. T., Powell, N. D., Papenfuss, T., Karlsson, E. A., … & Sheridan, J. F. (2010). Influenza virus-specific immunological memory is enhanced by repeated social defeat. Journal of Immunology, 184: 2014–2025.Google Scholar
McEwen, B. S. (2007). Physiology and neurobiology of stress and adaptation: central role of the brain. Physiological Reviews, 87: 873–904.CrossRefGoogle ScholarPubMed
Medzhitov, R. (2008). Origin and physiological roles of inflammation. Nature, 454: 428–435.Google Scholar
Meier-Ewert, H. K., Ridker, P. M., Rifai, N., Regan, M. M., Price, M. J., Dinges, D. F., & Mullington, J. M. (2004). Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. Journal of the American College of Cardiology, 43: 678–683.Google Scholar
Miller, A. H., Ancoli-Israel, S., Bower, J. E., Capuron, L., & Irwin, M. R. (2008a). Neuroendocrine-immune mechanisms of behavioral comorbidities in patients with cancer. Journal of Clinical Oncology, 26: 971–982.Google Scholar
Miller, A. H., Maletic, V., & Raison, C. L. (2009a). Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biological Psychiatry, 65: 732–741.Google Scholar
Miller, G. E. & Chen, E. (2010). Harsh family climate in early life presages the emergence of a proinflammatory phenotype in adolescence. Psychological Science, 21: 848–856.Google Scholar
Miller, G. E., Chen, E., Fok, A. K., Walker, H., Lim, A., Nicholls, E. F., … & Kobor, M. S. (2009b). Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling. Proceedings of the National Academy of Sciences of the USA, 106: 14716–14721.Google Scholar
Miller, G. E., Chen, E., Sze, J., Marin, T., Arevalo, J. M., Doll, R., … & Cole, S. W. (2008b). A functional genomic fingerprint of chronic stress in humans: blunted glucocorticoid and increased NF-kappaB signaling. Biological Psychiatry, 64: 266–272.Google Scholar
Miller, G. E. & Cohen, S. (2001). Psychological interventions and the immune system: a meta-analytic review and critique. Health Psychology, 20: 47–63.Google Scholar
Miller, G. E., Cohen, S., Pressman, S. D., Barkin, A., Rabin, B., & Treanor, J. J. (2004). Psychological stress and antibody response to influenza vaccination: when is the critical period for stress, and how does it get inside the body? Psychosomatic Medicine, 66: 215–223.Google Scholar
Miller, G. E. & Cole, S. W. (1998). Social relationships and the progression of human immunodeficiency virus infection: a review of evidence and possible underlying mechanisms. Annals of Behavioral Medicine, 20: 181–189.Google Scholar
Miller, N. E. (1964). Some psychophysiological studies of the motivation and of the behavioral effects of illness. Bulletin of the British Psychological Society, 17: 1–20.Google Scholar
Moons, W. G., Eisenberger, N. I., & Taylor, S. E. (2010). Anger and fear responses to stress have different biological profiles. Brain, Behavior, and Immunity, 24: 215–219.Google Scholar
Morgan, N., Irwin, M. R., Chung, M., & Wang, C. (2014). The effects of mind–body therapies on the immune system: meta-analysis. PLoS One, 9: e100903.Google Scholar
Motivala, S. & Irwin, M.R. (2007). Sleep and immunity: cytokine pathways linking sleep and health outcomes. Current Directions in Psychological Science, 16: 21–25.Google Scholar
Mullington, J., Korth, C., Hermann, D. M., Orth, A., Galanos, C., Holsboer, F., & Pollmächer, T. (2000). Dose-dependent effects of endotoxin on human sleep. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 278: R947–R955.Google Scholar
Murphy, K. (2001). Janeway’s Immunobiology. New York: Garland.Google Scholar
Murphy, M. L. M., Slavich, G. M., Chen, E., & Miller, G. E. (2015). Targeted rejection predicts decreased anti-inflammatory gene expression and increased symptom severity in youth with asthma. Psychological Science, 26: 111–121.Google Scholar
Murphy, M. L. M., Slavich, G. M., Rohleder, N., & Miller, G. E. (2013). Targeted rejection triggers differential pro- and anti-inflammatory gene expression in adolescents as a function of social status. Clinical Psychological Science, 1: 30–40.CrossRefGoogle ScholarPubMed
Murray, D. R., Irwin, M., Rearden, C. A., Ziegler, M., Motulsky, H., & Maisel, M. S. (1992). Sympathetic and immune interactions during dynamic exercise: mediation via Beta2-adrenergic dependent mechanism. Circulation, 83: 203–213.Google Scholar
Nance, D. M. & Sanders, V. M. (2007). Autonomic innervation and regulation of the immune system (1987–2007). Brain, Behavior, and Immunity, 21: 736–745.Google Scholar
Nicklas, B. J., Hsu, F. C., Brinkley, T. J., Church, T., Goodpaster, B. H., Kritchevsky, S. B., & Pahor, M. (2008). Exercise training and plasma C-reactive protein and interleukin-6 in elderly people. Journal of the American Geriatrics Society, 56: 2045–2052.Google Scholar
O’Connor, M. F., Bower, J. E., Cho, H. J., Creswell, J. D., Dimitrov, S., Hamby, M. E., … & Irwin, M. R. (2009). To assess, to control, to exclude: effects of biobehavioral factors on circulating inflammatory markers. Brain, Behavior, and Immunity, 23: 887–897.Google Scholar
O’Connor, M. F., Motivala, S., Valladares, E. M., Olmstead, R. E., & Irwin, M. R. (2007). Sex differences in monocyte expression of IL-6: role of autonomic mechanisms. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 293: R145–R151.Google Scholar
O’Donovan, A., Slavich, G. M., Epel, E. S., & Neylen, T. C. (2013). Exaggerated neurobiological sensitivity to threat as a mechanism linking anxiety with increased risk for diseases of aging. Neuroscience & Biobehavioral Reviews, 37: 96–108.Google Scholar
Pace, T. W., Hu, F., & Miller, A. H. (2007). Cytokine-effects on glucocorticoid receptor function: relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression. Brain, Behavior, and Immunity, 21: 9–19.Google Scholar
Pace, T. W., Mletzko, T. C., Alagbe, O., Musselman, D. L., Nemeroff, C. B., Miller, A. H., & Heim, C. M. (2006). Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress. American Journal of Psychiatry, 163: 1630–1633.Google Scholar
Panina-Bordignon, P., Mazzeo, D., Di Lucia, P., D’Ambrosio, D., Lang, R., Fabbri, L., … & Sinigaglia, F. (1997). β2-agonists prevent Th1 development by selective inhibition of interleukin 12. Journal of Clinical Investigation, 100: 1513–1519.Google Scholar
Patel, S. R., Malhotra, A., Gao, X., Hu, F. B., Neuman, M. I., & Fawzi, W. W. (2012). A prospective study of sleep duration and pneumonia risk in women. Sleep, 35: 97–101.Google Scholar
Patten, S. B., Williams, J. V. A., Lavorato, D. H., Modgill, G., Jetté, N., & Eliasziw, M. (2008). Major depression as a risk factor for chronic disease incidence: longitudinal analyses in a general population cohort. General Hospital Psychiatry, 30: 407–413.Google Scholar
Phillips, A. C., Carroll, D., Burns, V. E., & Drayson, M. (2009). Cardiovascular activity and the antibody response to vaccination. Journal of Psychosomatic Research, 67: 37–43.Google Scholar
Polsky, D., Doshi, J. A., Marcus, S., Oslin, D., Rothbard, A., Thomas, N., & Thompson, C. L. (2005). Long-term risk for depressive symptoms after a medical diagnosis. Archives of Internal Medicine, 165: 1260–1266.Google Scholar
Powell, N. D., Mays, J. W., Bailey, M. T., Hanke, M. L., & Sheridan, J. F. (2011). Immunogenic dendritic cells primed by social defeat enhance adaptive immunity to influenza A virus. Brain, Behavior, and Immunity, 25 (1): 46–52.Google Scholar
Prather, A. A., Hall, M., Fury, J. M., Ross, D. C., Muldoon, M. F., Cohen, S., & Marsland, A. L. (2012). Sleep and antibody response to hepatitis B vaccination. Sleep, 35: 1063–1069.Google Scholar
Raetz, C. R. & Whitfield, C. (2002). Lipopolysaccharide endotoxins. Annual Review of Biochemistry, 71: 635–700.Google Scholar
Raison, C. L. & Miller, A. H. (2003). Depression in cancer: new developments regarding diagnosis and treatment. Biological Psychiatry, 54: 283–294.Google Scholar
Raison, C. L., Rutherford, R. E., Woolwine, B. J., Shuo, C., Schettler, P., Drake, D. F., … & Miller, A. H. (2013). A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers. JAMA Psychiatry, 70: 31–41.Google Scholar
Raison, C. L., Rye, D. B., Woolwine, B. J., Vogt, G. J., Bautista, B. M., Spivey, J. R., & Miller, A. H. (2010). Chronic interferon-alpha administration disrupts sleep continuity and depth in patients with hepatitis C: association with fatigue, motor slowing, and increased evening cortisol. Biological Psychiatry, 68: 942–949.Google Scholar
Renegar, K. B., Floyd, R. A., & Krueger, J. M. (1998). Effects of short-term sleep deprivation on murine immunity to influenza virus in young adult and senescent mice. Sleep, 21: 241–248.Google Scholar
Rhen, T. & Cidlowski, J. A. (2005). Antiinflammatory action of glucocorticoids: new mechanisms for old drugs. New England Journal of Medicine, 353: 1711–1723.CrossRefGoogle ScholarPubMed
Richlin, V. A., Arevalo, J. M., Zack, J. A., & Cole, S. W. (2004). Stress-induced enhancement of NF-kappaB DNA-binding in the peripheral blood leukocyte pool: effects of lymphocyte redistribution. Brain, Behavior, and Immunity, 18: 231–237.Google Scholar
Rooney, A. G., McNamara, S., Mackinnon, M., Fraser, M., Rampling, R., Carson, A., & Grant, R. (2011). Frequency, clinical associations, and longitudinal course of major depressive disorder in adults with cerebral glioma. Journal of Clinical Oncology, 29: 4307–4312.Google Scholar
Sapolsky, R., Rivier, C., Yamamoto, G., Plotsky, P., & Vale, W. (1987). Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor. Science, 238: 522–524.Google Scholar
Schleifer, S. J., Keller, S. E., & Bartlett, J. A. (1999). Depression and immunity: clinical factors and therapeutic course. Psychiatry Research, 85: 63–69.Google Scholar
Schultze-Florey, C. R., Martínez-Maza, O., Magpantay, L., Breen, E. C., Irwin, M. R., Gündel, H., & O’Connor, M.-F. (2012). When grief makes you sick: bereavement induced systemic inflammation is a question of genotype. Brain, Behavior, and Immunity, 26: 1066–1071.Google Scholar
Slavich, G. M. (2015). Understanding inflammation, its regulation, and relevance for health: a top scientific and public priority. Brain, Behavior, and Immunity, 45: 13–14.Google Scholar
Slavich, G. M. & Cole, S. W. (2013). The emerging field of human social genomics. Clinical Psychological Science, 1: 331–348.Google Scholar
Slavich, G. M. & Irwin, M. R. (2014). From stress to inflammation and major depressive disorder: a social signal transduction theory of depression. Psychological Bulletin, 140: 774–815.Google Scholar
Slavich, G. M., Monroe, S. M., & Gotlib, I. H. (2011). Early parental loss and depression history: associations with recent life stress in major depressive disorder. Journal of Psychiatric Research, 45: 1146–1152.Google Scholar
Slavich, G. M., O’Donovan, A., Epel, E. S., & Kemeny, M. E. (2010). Black sheep get the blues: a psychobiological model of social rejection and depression. Neuroscience & Biobehavioral Reviews, 35: 39–45.Google Scholar
Slavich, G. M., Tartter, M. A., Brennan, P. A., & Hammen, C. (2014). Endogenous opioid system influences depressive reactions to socially painful targeted rejection life events. Psychoneuroendocrinology, 49: 141–149.CrossRefGoogle ScholarPubMed
Slavich, G. M., Thornton, T., Torres, L. D., Monroe, S. M., & Gotlib, I. H. (2009). Targeted rejection predicts hastened onset of major depression. Journal of Social and Clinical Psychology, 28: 223–243.Google Scholar
Sloan, E. K., Capitanio, J. P., Tarara, R. P., Mendoza, S. P., Mason, W. A., & Cole, S. W. (2007). Social stress enhances sympathetic innervation of primate lymph nodes: mechanisms and implications for viral pathogenesis. Journal of Neuroscience, 27: 8857–8865.Google Scholar
Smith, C. W., Marlin, S. D., Rothlein, R., Toman, C., & Anderson, D. C. (1989). Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro. Journal of Clinical Investigation, 83: 2008–2017.Google Scholar
Spiegel, K., Sheridan, J. F., & Van Cauter, E. (2002). Effect of sleep deprivation on response to immunization. Journal of the American Medical Association, 288: 1471–1472.Google Scholar
Thomas, K. S., Motivala, S., Olmstead, R., & Irwin, M. R. (2011). Sleep depth and fatigue: role of cellular inflammatory activation. Brain, Behavior, and Immunity, 25: 53–58.Google Scholar
Torres, M. A., Pace, T. W., Liu, T., Felger, J. C., Mister, D., Doho, G. H., … & Miller, A. H. (2013). Predictors of depression in breast cancer patients treated with radiation: role of prior chemotherapy and nuclear factor kappa B. Cancer, 119: 1951–1959.Google Scholar
Tyring, S., Gottlieb, A., Papp, K., Gordon, K., Leonardi, C., Wang, A., … & Krishnan, R. (2006). Etanercept and clinical outcomes, fatigue, and depression in psoriasis: double-blind placebo-controlled randomised phase III trial. Lancet, 367: 29–35.Google Scholar
Vedhara, K., Cox, N. K. M., Wilcock, G. K., Perks, P., Hunt, M., Anderson, S., … & Shanks, N. M. (1999). Chronic stress in elderly carers of dementia patients and antibody response to influenza vaccination. Lancet, 353: 627–631.Google Scholar
Wang, C., Banuru, R., Ramel, J., Kupelnick, B., Scott, T., & Schmid, C. H. (2010). Tai Chi on psychological well-being: systematic review and meta-analysis. BMC Complementary and Alternative Medicine, 10: 23.Google Scholar
Wang, C., Collet, J. P., & Lau, J. (2004). The effect of Tai Chi on health outcomes in patients with chronic conditions: a systematic review. Archives of Internal Medicine, 164: 493–501.Google Scholar
Watkins, L. R. & Maier, S. F. (1999). Implications of immune-to-brain communication for sickness and pain. Proceedings of the National Academy of Sciences of the USA, 96: 7710–7713.CrossRefGoogle ScholarPubMed
Wohleb, E. S., Hanke, M. L., Corona, A. W., Powell, N. D., Stiner, L. T. M., Bailey, M. T., … & Sheridan, J. F. (2011). Beta-adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat. Journal of Neuroscience, 31: 6277–6288.Google Scholar
Zautra, A. J., Davis, M. C., Reich, J. W., Nicassario, P., Tennen, H., Finan, P., … & Irwin, M. R. (2008). Comparison of cognitive behavioral and mindfulness meditation interventions on adaptation to rheumatoid arthritis for patients with and without history of recurrent depression. Journal of Consulting and Clinical Psychology, 76: 408–421.Google Scholar
Zautra, A. J., Yocum, D. C., Villanueva, I., Smith, B., Davis, M. C., Attrep, J., & Irwin, M. (2004). Immune activation and depression in women with rheumatoid arthritis. Journal of Rheumatology, 31: 457–463.Google Scholar

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