Book contents
- Fetal Therapy
- Fetal Therapy
- Copyright page
- Dedication
- Contents
- Contributors
- Foreword
- Section 1: General Principles
- Section 2: Fetal Disease: Pathogenesis and Treatment
- Red Cell Alloimmunization
- Chapter 10 Management of Red Cell Alloimmunization
- Chapter 11 Fetal and Neonatal Alloimmune Thrombocytopenia: Clinical Disease and Management
- Structural Heart Disease in the Fetus
- Fetal Dysrhythmias
- Manipulation of Fetal Amniotic Fluid Volume
- Fetal Infections
- Fetal Growth and Well-being
- Preterm Birth of the Singleton and Multiple Pregnancy
- Complications of Monochorionic Multiple Pregnancy: Twin-to-Twin Transfusion Syndrome
- Complications of Monochorionic Multiple Pregnancy: Fetal Growth Restriction in Monochorionic Twins
- Complications of Monochorionic Multiple Pregnancy: Twin Reversed Arterial Perfusion Sequence
- Complications of Monochorionic Multiple Pregnancy: Multifetal Reduction in Multiple Pregnancy
- Fetal Urinary Tract Obstruction
- Pleural Effusion and Pulmonary Pathology
- Surgical Correction of Neural Tube Anomalies
- Fetal Tumors
- Congenital Diaphragmatic Hernia
- Fetal Stem Cell Transplantation
- Gene Therapy
- Section III: The Future
- Index
- References
Chapter 11 - Fetal and Neonatal Alloimmune Thrombocytopenia: Clinical Disease and Management
from Red Cell Alloimmunization
Published online by Cambridge University Press: 21 October 2019
- Fetal Therapy
- Fetal Therapy
- Copyright page
- Dedication
- Contents
- Contributors
- Foreword
- Section 1: General Principles
- Section 2: Fetal Disease: Pathogenesis and Treatment
- Red Cell Alloimmunization
- Chapter 10 Management of Red Cell Alloimmunization
- Chapter 11 Fetal and Neonatal Alloimmune Thrombocytopenia: Clinical Disease and Management
- Structural Heart Disease in the Fetus
- Fetal Dysrhythmias
- Manipulation of Fetal Amniotic Fluid Volume
- Fetal Infections
- Fetal Growth and Well-being
- Preterm Birth of the Singleton and Multiple Pregnancy
- Complications of Monochorionic Multiple Pregnancy: Twin-to-Twin Transfusion Syndrome
- Complications of Monochorionic Multiple Pregnancy: Fetal Growth Restriction in Monochorionic Twins
- Complications of Monochorionic Multiple Pregnancy: Twin Reversed Arterial Perfusion Sequence
- Complications of Monochorionic Multiple Pregnancy: Multifetal Reduction in Multiple Pregnancy
- Fetal Urinary Tract Obstruction
- Pleural Effusion and Pulmonary Pathology
- Surgical Correction of Neural Tube Anomalies
- Fetal Tumors
- Congenital Diaphragmatic Hernia
- Fetal Stem Cell Transplantation
- Gene Therapy
- Section III: The Future
- Index
- References
Summary
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is one of the most important causes of thrombocytopenia in otherwise healthy, term-born infants [1]. During fetal life, the fetal platelet count rapidly increases and reaches a constant normal level, equal to adults, by the end of the first trimester. Therefore, the definition of a normal platelet count and thrombocytopenia in fetuses and neonates is equal to adults. Normal platelet counts range from 150–450 × 109/L and a (fetal or neonatal) platelet count below the 5th percentile, 150×109/L, is defined as thrombocytopenia [2]. Further classification into different degrees of thrombocytopenia can be made into mild (100–150 × 109/L), moderate (50–100 × 109/L), severe (<50 × 109/L), and very severe thrombocytopenia (<20–30 × 109/L).
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- Information
- Fetal TherapyScientific Basis and Critical Appraisal of Clinical Benefits, pp. 99 - 109Publisher: Cambridge University PressPrint publication year: 2020