Book contents
- Fetal Therapy
- Fetal Therapy
- Copyright page
- Dedication
- Contents
- Contributors
- Foreword
- Section 1: General Principles
- Section 2: Fetal Disease: Pathogenesis and Treatment
- Red Cell Alloimmunization
- Structural Heart Disease in the Fetus
- Fetal Dysrhythmias
- Manipulation of Fetal Amniotic Fluid Volume
- Fetal Infections
- Fetal Growth and Well-being
- Preterm Birth of the Singleton and Multiple Pregnancy
- Chapter 27 The Pathogenesis of Preterm Birth: A Guide to Potential Therapeutic Targets
- Chapter 28 Clinical Interventions for the Prevention and Management of Spontaneous Preterm Birth in the Singleton Fetus
- Chapter 29 Clinical Interventions to Prevent Preterm Birth in Multiple Pregnancies
- Chapter 30 Reducing Neurologic Morbidity from Preterm Birth through Administering Therapy Prior to Delivery
- Complications of Monochorionic Multiple Pregnancy: Twin-to-Twin Transfusion Syndrome
- Complications of Monochorionic Multiple Pregnancy: Fetal Growth Restriction in Monochorionic Twins
- Complications of Monochorionic Multiple Pregnancy: Twin Reversed Arterial Perfusion Sequence
- Complications of Monochorionic Multiple Pregnancy: Multifetal Reduction in Multiple Pregnancy
- Fetal Urinary Tract Obstruction
- Pleural Effusion and Pulmonary Pathology
- Surgical Correction of Neural Tube Anomalies
- Fetal Tumors
- Congenital Diaphragmatic Hernia
- Fetal Stem Cell Transplantation
- Gene Therapy
- Section III: The Future
- Index
- References
Chapter 29 - Clinical Interventions to Prevent Preterm Birth in Multiple Pregnancies
from Preterm Birth of the Singleton and Multiple Pregnancy
Published online by Cambridge University Press: 21 October 2019
- Fetal Therapy
- Fetal Therapy
- Copyright page
- Dedication
- Contents
- Contributors
- Foreword
- Section 1: General Principles
- Section 2: Fetal Disease: Pathogenesis and Treatment
- Red Cell Alloimmunization
- Structural Heart Disease in the Fetus
- Fetal Dysrhythmias
- Manipulation of Fetal Amniotic Fluid Volume
- Fetal Infections
- Fetal Growth and Well-being
- Preterm Birth of the Singleton and Multiple Pregnancy
- Chapter 27 The Pathogenesis of Preterm Birth: A Guide to Potential Therapeutic Targets
- Chapter 28 Clinical Interventions for the Prevention and Management of Spontaneous Preterm Birth in the Singleton Fetus
- Chapter 29 Clinical Interventions to Prevent Preterm Birth in Multiple Pregnancies
- Chapter 30 Reducing Neurologic Morbidity from Preterm Birth through Administering Therapy Prior to Delivery
- Complications of Monochorionic Multiple Pregnancy: Twin-to-Twin Transfusion Syndrome
- Complications of Monochorionic Multiple Pregnancy: Fetal Growth Restriction in Monochorionic Twins
- Complications of Monochorionic Multiple Pregnancy: Twin Reversed Arterial Perfusion Sequence
- Complications of Monochorionic Multiple Pregnancy: Multifetal Reduction in Multiple Pregnancy
- Fetal Urinary Tract Obstruction
- Pleural Effusion and Pulmonary Pathology
- Surgical Correction of Neural Tube Anomalies
- Fetal Tumors
- Congenital Diaphragmatic Hernia
- Fetal Stem Cell Transplantation
- Gene Therapy
- Section III: The Future
- Index
- References
Summary
Twin, triplet or higher order pregnancies are referred to as multiple pregnancies. The prevalence of multiple pregnancies is around 1 per 80 live births [1]. Twins can be either dizygotic, resulting from the fertilization of two separate ova during a single ovulatory cycle, or monozygotic, resulting from a single fertilized ovum that subsequently divides into two separate individuals. Dizygotic twins are more prevalent than monozygotic twins. Higher order multiples can result from either or both processes. Monozygotic twins can either be dichorionic (1/3), monochorionic (2/3), or mono-amniotic (1/3). Which type of monozygotic twin eventually develops depends on the moment of splitting of the fertilized ovum. If the ovum splits within the first 3 days dichorionic twins develop, if the ovum splits between 4 and 8 days monochorionic/diamniotic twins develop, between 8 and 12 days mono-amniotic twins develop, and if the ovum splits after 12 days this gives rise to conjoined twins.
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- Fetal TherapyScientific Basis and Critical Appraisal of Clinical Benefits, pp. 325 - 332Publisher: Cambridge University PressPrint publication year: 2020