Ward, E, Desantis, C, Robbins, Aet al. Childhood and adolescent cancer statistics, 2014. CA Cancer J Clin, 2014; 64(2): 83–103.Google ScholarPubMed

Lee, SJ, Schover, LR, Partridge, AH et al. American Society of Clinical Oncology recommendations on fertility preservation in cancer patients. J Clin Oncol, 2006;24:2917–2931.CrossRefGoogle Scholar

Mertens, AC, Yasui, Y, Neglia, JP et al. Late mortality experience in five-year survivors of childhood and adolescent cancer: The Childhood Cancer Survivor Study. J Clin Oncol, 2001;19:3163–3172.Google Scholar

Jeruss, JS, Woodruff, TK. Preservation of fertility in patients with cancer. NEJM, 2009;360:902–911.Google Scholar

Ginsberg, JP, Li, Y, Carlson, CA et al. Testicular tissue cryopreservation in prepubertal male children: an analysis of parental decision-making. Pediatr Blood Cancer, 2014;61:1673–1678.Google Scholar

Opsahl, MS, Fugger, EF, Sherins, RJ, Schulman, JD. Preservation of reproductive function before therapy for cancer: new options involving sperm and ovary cryopreservation. Cancer J Sci Am, 1997;3:189–191.Google Scholar

Chen, SU, Ho, HN, Chen, HF et al. Pregnancy achieved by intracytoplasmic sperm injection using cryopreserved semen from a man with testicular cancer. Hum Reprod, 1996;11:2645–2647.CrossRefGoogle Scholar

Kliesch, S, Behre, HM, Jurgens, H, Nieschlag, E. Cryopreservation of semen from adolescent patients with malignancies. Med Pediatr Oncol, 1996;26:20–27.3.0.CO;2-X>CrossRefGoogle ScholarPubMed

Wallace, WH, Anderson, RA, Irvine, DS. Fertility preservation for young patients with cancer: who is at risk and what can be offered? Lancet Oncol, 2005;6:209–218.Google Scholar

Damani, MN, Masters, V, Meng, MV et al. Postchemotherapy ejaculatory azoospermia: fatherhood with sperm from testis tissue with intracytoplasmic sperm injection. J Clin Oncol, 2002;20:930–936.CrossRefGoogle ScholarPubMed

Brinster, RL. Germline stem cell transplantation and transgenesis. Science, 2002;296:2174–2176.Google Scholar

Culty, M. Gonocytes, the forgotten cells of the germ cell lineage. Birth Defects Res C Embryo Today, 2009;87:1–26.CrossRefGoogle ScholarPubMed

Paniagua, R, Nistal, M. Morphological and histometric study of human spermatogonia from birth to the onset of puberty. J Anat, 1984;139(Pt3):535–552.Google Scholar

Brinster, RL. Male germline stem cells: From mice to men. Science, 2007;316:404–405.Google Scholar

Brinster, RL, Zimmermann, JW. Spermatogenesis following male germ-cell transplantation. Proc Natl Acad Sci U S A, 1994;91:11298–11302.CrossRefGoogle ScholarPubMed

Wyns, C, Curaba, M, Vanabelle, B, Van Langendonckt, A, Donnez, J. Options for fertility preservation in prepubertal boys. Hum Reprod Update, 2010;16:312–328.Google Scholar

Avarbock, MR, Brinster, CJ, Brinster, RL. Reconstitution of spermatogenesis from frozen spermatogonial stem cells. Nat Med, 1996;2:693–696.Google Scholar

Nagano, M, Patrizio, P, Brinster, RL. Long-term survival of human spermatogonial stem cells in mouse testes. Fertil Steril, 2002;78:1225–1233.Google Scholar

Bahadur, G, Chatterjee, R, Ralph, D. Testicular tissue cryopreservation in boys. Ethical and legal issues: Case report. Hum Reprod, 2000;15:1416–1420.Google Scholar

Ketola, I, Rahman, N, Toppari, J et al. Expression and regulation of transcription factors GATA-4 and GATA-6 in developing mouse testis. Endocrinology, 1999;140:1470–1480.CrossRefGoogle ScholarPubMed

Nagano, M, Avarbock, MR, Leonida, EB, Brinster, CJ, Brinster, RL. Culture of mouse spermatogonial stem cells. Tissue Cell, 1998;30:389–397.Google Scholar

Brinster, RL, Avarbock, MR. Germline transmission of donor haplotype following spermatogonial transplantation. Proc Natl Acad Sci U S A, 1994;91:11303–11307.Google Scholar

Kubota, H, Brinster, RL. Spermatogonial stem cells. Biol Reprod, 2018;99:52–74.Google Scholar

Nieman, CL, Kazer, R, Brannigan, RE et al. Cancer survivors and infertility: a review of a new problem and novel answers. J Support Oncol, 2006;4:171–178.Google Scholar

Tegelenbosch, RA, de Rooij, DG. A quantitative study of spermatogonial multiplication and stem cell renewal in the C3 H/101 F1 hybrid mouse. Mutat Res, 1993;290:193–200.CrossRefGoogle Scholar

Kanatsu-Shinohara, M, Ogonuki, N, Inoue, K et al. Long-term proliferation in culture and germline transmission of mouse male germline stem cells. Biol Reprod, 2003;69:612–616.Google Scholar

Kubota, H, Avarbock, MR, Brinster, RL. Growth factors essential for self-renewal and expansion of mouse spermatogonial stem cells. Proc Natl Acad Sci U S A, 2004;101:16489–16494.Google Scholar

Ryu, BY, Kubota, H, Avarbock, MR, Brinster, RL. Conservation of spermatogonial stem cell self-renewal signaling between mouse and rat. Proc Natl Acad Sci U S A, 2005;102:14302–14307.Google Scholar

Wu, X, Schmidt, JA, Avarbock, MR et al. Prepubertal human spermatogonia and mouse gonocytes share conserved gene expression of germline stem cell regulatory molecules. Proc Natl Acad Sci U S A, 2009;106:21672–21677.CrossRefGoogle ScholarPubMed

Luo, J, Megee, S, Rathi, R, Dobrinski, I. Protein gene product 9.5 is a spermatogonia-specific marker in the pig testis: application to enrichment and culture of porcine spermatogonia. Mol Reprod Dev, 2006;73:1531–1540.Google Scholar

Reijo, R, Seligman, J, Dinulos, MB et al. Mouse autosomal homolog of DAZ, a candidate male sterility gene in humans, is expressed in male germ cells before and after puberty. Genomics, 1996;35:346–352.Google Scholar

Shinohara, T, Avarbock, MR, Brinster, RL. Beta1- and Alpha6-integrin are surface markers on mouse spermatogonial stem cells. Proc Natl Acad Sci U S A, 1999;96:5504–5509.Google Scholar

Shinohara, T, Orwig, KE, Avarbock, MR, Brinster, RL. Spermatogonial stem cell enrichment by multiparameter selection of mouse testis cells. Proc Natl Acad Sci U S A, 2000;97:8346–8351.Google Scholar

Oatley, JM, Avarbock, MR, Telaranta, AI, Fearon, DT, Brinster, RL. Identifying genes important for spermatogonial stem cell self-renewal and survival. Proc Natl Acad Sci U S A, 2006;103:9524–9529.CrossRefGoogle ScholarPubMed

Schmidt, JA, Avarbock, MR, Tobias, JW, Brinster, RL. Identification of glial cell line-derived neurotrophic factor-regulated genes important for spermatogonial stem cell self-renewal in the rat. Biol Reprod, 2009;81:56–66.Google Scholar

Oatley, JM, Brinster, RL. Regulation of spermatogonial stem cell self-renewal in mammals. Annu Rev Cell Dev Biol, 2008;24:263–286.Google Scholar

Hamra, FK, Schultz, N, Chapman, KM et al. Defining the spermatogonial stem cell. Dev Biol, 2004;269:393–410.Google Scholar

Tyagi, G, Carnes, K, Morrow, C et al. Loss of Etv5 decreases proliferation and RET levels in neonatal mouse testicular germ cells and causes an abnormal first wave of spermatogenesis. Biol Reprod, 2009;81:258–266.Google Scholar

Kubota, H, Wu, X, Goodyear, SM, Avarbock, MR, Brinster, RL. Glial cell line-derived neurotrophic factor and endothelial cells promote self-renewal of rabbit germ cells with spermatogonial stem cell properties. FASEB J, 2011;25:2604–2614.Google Scholar

Sadri-Ardekani, H, Mizrak, SC, van Daalen, SK et al. Propagation of human spermatogonial stem cells in vitro. JAMA, 2009;302:2127–2134.Google Scholar

Bhang, DH, Kim B-J, Kim BG, et al. Testicular endothelial cells are a critical population in germline stem cell niche. Nat Comm, 2018; 9:4379.Google Scholar

Keros, V, Hultenby, K, Borgstrom, B et al. Methods of cryopreservation of testicular tissue with viable spermatogonia in pre-pubertal boys undergoing gonadotoxic cancer treatment. Hum Reprod, 2007;22:1384–1395.Google Scholar

Hermann, BP, Sukhwani, M, Winkler, F et al. Spermatogonial stem cell transplantation into rhesus testes regenerates spermatogenesis producing functional sperm. Cell Stem Cell, 2012;11:715–726.CrossRefGoogle ScholarPubMed

Wu, X, Goodyear, SM, Abramowitz, LK et al. Fertile offspring derived from mouse spermatogonial stem cells cryopreserved for more than 14 years. Hum Reprod, 2012;27:1249–1259.CrossRefGoogle Scholar

Lee, YA, Kim, YH, Ha, SJ et al. Effect of sugar molecules on the cryopreservation of mouse spermatogonial stem cells. Fertil Steril, 2014;101:1165–1175 e1165.Google Scholar

Lee, YA, Kim, YH, Kim, BJ et al. Cryopreservation in trehalose preserves functional capacity of murine spermatogonial stem cells. PloS One, 2013;8:e54889.Google Scholar

Ha, SJ, Kim, BG, Lee, YA et al. Effect of antioxidants and apoptosis inhibitors on cryopreservation of murine germ cells enriched for spermatogonial stem cells. PloS One, 2016;11:e0161372.Google Scholar

Grundy, R, Gosden, RG, Hewitt, M et al. Fertility preservation for children treated for cancer (1): Scientific advances and research dilemmas. Arch Dis Child, 2001;84:355–359.Google Scholar

Grundy, R, Larcher, V, Gosden, RG et al. Fertility preservation for children treated for cancer (2): ethics of consent for gamete storage and experimentation. Arch Dis Child, 2001;84:360–362.Google Scholar

Willemse, MJ, Seriu, T, Hettinger, K et al. Detection of minimal residual disease identifies differences in treatment response between T-ALL and precursor B-ALL. Blood, 2002;99:4386–4393.CrossRefGoogle ScholarPubMed

Geens, M, Van de Velde, H, De Block, G et al. The efficiency of magnetic-activated cell sorting and fluorescence-activated cell sorting in the decontamination of testicular cell suspensions in cancer patients. Hum Reprod, 2007;22:733–742.Google Scholar

Jolkowska, J, Derwich, K, Dawidowska, M. Methods of minimal residual disease (MRD) detection in childhood haematological malignancies. J Appl Genet, 2007;48:77–83.Google Scholar

Fujita, K, Ohta, H, Tsujimura, A et al. Transplantation of spermatogonial stem cells isolated from leukemic mice restores fertility without inducing leukemia. J Clin Invest, 2005;115:1855–1861.Google Scholar

Jahnukainen, K, Hou, M, Petersen, C, Setchell, B, Soder, O. Intratesticular transplantation of testicular cells from leukemic rats causes transmission of leukemia. Cancer Res, 2001;61:706–710.Google Scholar

Sadri-Ardekani, H, Homburg, CH, van Capel, TM et al. Eliminating acute lymphoblastic leukemia cells from human testicular cell cultures: a pilot study. Fertil Steril, 2014;101:1072–1078 e1071.Google Scholar

Hovatta, O. Cryopreservation of testicular tissue in young cancer patients. Hum Reprod Update, 2001;7:378–383.Google Scholar

Cohen, CB. Ethical issues regarding fertility preservation in adolescents and children. Pediatr Blood Cancer, 2009;53:249–253.Google Scholar

Sugarman, J, Rosoff, PM. Ethical issues in gamete preservation for children undergoing treatment for cancer. J Androl, 2001;22:732–737.Google Scholar

Wyns, C, Collienne, C, Shenfield, F et al. Fertility preservation in the male pediatric population: factors influencing the decision of parents and children. Hum Reprod, 2015;30:2022–2030.Google Scholar

Fallat, ME, Hutter, J. Preservation of fertility in pediatric and adolescent patients with cancer. Pediatrics, 2008;121:e1461-1469.Google Scholar

de Rooij, DG. Stem cells in the testis. Int J Exp Pathol, 1998;79:67–80.Google Scholar

Robison, LL, Hudson, MM. Survivors of childhood and adolescent cancer: life-long risks and responsibilities. Nat Rev Cancer, 2014;14:61–70.Google Scholar

Picton, HM, Wyns, C, Anderson, RA et al. A European perspective on testicular tissue cryopreservation for fertility preservation in prepubertal and adolescent boys. Hum Reprod, 2015;30:2463–2475.Google Scholar

Vento, F Del, Vermeulen, M, Michele, F de et al. Tissue engineering to improve immature testicular tissue and cell transplantation outcomes: one step closer to fertility restoration for prepubertal boys exposed to gonadotoxic treatments. Int J Mol Sci, 2018;19:286.Google Scholar

Jahnukainen, K, Ehmcke, J, Hou, M, Schlatt, S. Testicular function and fertility preservation in male cancer patients. Best Pract Res Clin Endocrinol Metab, 2011;25:287–302.Google Scholar

Alphen, MMA van, Kant HJG, van de, Rooij, DG de. Repopulation of the seminiferous epithelium of the rhesus monkey after X irradiation. Radiat Res, 1988;113:487–500.Google Scholar

Stukenborg, J-B, Jahnukainen, K, Hutka, M, Mitchell, RT. Cancer treatment in childhood and testicular function: the role of the somatic environment. Endocr Connect, 2018;EC-17–0382.Google Scholar

Skinner, R, Mulder, RL, Kremer, LC et al. Recommendations for gonadotoxicity surveillance in male childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCareSurFup Consort. Lancet Oncol, 2017;18:e75–e90.Google Scholar

Heckmann, L, Langenstroth-Röwer, D, Pock, T et al. A diagnostic germ cell score for immature testicular tissue at risk of germ cell loss. Hum Reprod, 2018;33:636–645.Google Scholar

Anderson, RA, Mitchell, RT, Kelsey, TW et al. Cancer treatment and gonadal function: experimental and established strategies for fertility preservation in children and young adults. Lancet Diabetes Endocrinol, 2015;3:556–567.CrossRefGoogle ScholarPubMed

Wallace, WHB, Anderson, RA, Irvine, DS. Fertility preservation for young patients with cancer: who is at risk and what can be offered? Lancet Oncol, 2005;6:209–218.Google Scholar

Keros, V, Hultenby, K, Borgström, B et al. Methods of cryopreservation of testicular tissue with viable spermatogonia in pre-pubertal boys undergoing gonadotoxic cancer treatment. Hum Reprod, 2007;22:1384–1395.Google Scholar

Stukenborg, J-B, Alves-Lopes, JP, Kurek, M et al. Spermatogonial quantity in human prepubertal testicular tissue collected for fertility preservation prior to potentially sterilizing therapy. Hum Reprod, 2018;33(9):1677–1683.Google Scholar

Wyns, C, Langendonckt, A Van, Wese, FX, Donnez, J, Curaba, M. Long-term spermatogonial survival in cryopreserved and xenografted immature human testicular tissue. Hum Reprod, 2008;23:2402–2414.Google Scholar

Baert, Y, Saen, D Van, Haentjens, P et al. What is the best cryopreservation protocol for human testicular tissue banking? Hum Reprod, 2013;28:1816–1826.Google Scholar

Wyns, C, Curaba, M, Martinez-Madrid, B et al. Spermatogonial survival after cryopreservation and short-term orthotopic immature human cryptorchid testicular tissue grafting to immunodeficient mice. Hum Reprod, 2007;22:1603–1611.CrossRefGoogle ScholarPubMed

Wyns, C, Curaba, M, Petit, S et al. Management of fertility preservation in prepubertal patients: 5 years’ experience at the Catholic University of Louvain. Hum Reprod, 2011;26:737–747.Google Scholar

Saen, D Van, Vloeberghs, V, Gies, I et al. When does germ cell loss and fibrosis occur in patients with Klinefelter syndrome? Hum Reprod, 2018;33:1009–1022.Google Scholar

Jahnukainen, K, Mitchell, RT, Stukenborg, JB. Testicular function and fertility preservation after treatment for haematological cancer. Curr Opin Endocrinol Diabetes Obes, 2015;22:217–223.Google Scholar

Masliukaite, I, Hagen, JM, Jahnukainen, K et al. Establishing reference values for age-related spermatogonial quantity in prepubertal human testes: a systematic review and meta-analysis. Fertil Steril, 2016;106:1652–1657.e2.Google Scholar

Poganitsch-Korhonen, M, Masliukaite, I, Nurmio, M et al. Decreased spermatogonial quantity in prepubertal boys with leukaemia treated with alkylating agents. Leukemia, 2017;31:1460–1463.Google Scholar

Tröndle, I, Westernströer, B, Wistuba, J et al. Irradiation affects germ and somatic cells in prepubertal monkey testis xenografts. Mol Hum Reprod, 2017;23:gax003.Google Scholar

Smart, E, Lopes, F, Rice, S et al. Chemotherapy drugs cyclophosphamide, cisplatin and doxorubicin induce germ cell loss in an in vitro model of the prepubertal testis. Sci Rep, 2018;8:1773.Google Scholar

Franik, S, Hoeijmakers, Y, D’Hauwers, K et al. Klinefelter syndrome and fertility: sperm preservation should not be offered to children with Klinefelter syndrome. Hum Reprod, 2016;31:1952–1959.Google Scholar

Onofre, J, Baert, Y, Faes, K, Goossens, E. Cryopreservation of testicular tissue or testicular cell suspensions: a pivotal step in fertility preservation. Hum Reprod Update, 2016;22:744–761.Google Scholar

Uijldert, M, Meißner, A, Melker, AA de et al. Development of the testis in pre-pubertal boys with cancer after biopsy for fertility preservation. Hum Reprod, 2017;32:2366–2372.Google Scholar

Keros, V, Rosenlund, B, Hultenby, K et al. Optimizing cryopreservation of human testicular tissue: Comparison of protocols with glycerol, propanediol and dimethylsulphoxide as cryoprotectants. Hum Reprod, 2005;20:1676–1687.Google Scholar

Baert, Y, Braye, A, Struijk, RB, Pelt, AMM van,Goossens, E. Cryopreservation of testicular tissue before long-term testicular cell culture does not alter in vitro cell dynamics. Fertil Steril, 2015;104:1244–1252.e4.Google Scholar

Kvist, K, Thorup, J, Byskov, AG et al. Cryopreservation of intact testicular tissue from boys with cryptorchidism. Hum Reprod, 2006;21:484–491.Google Scholar

Martinez, F. Update on fertility preservation from the Barcelona International Society for Fertility Preservation–ESHRE–ASRM 2015 expert meeting: indications, results and future perspectives. Hum Reprod, 2017;32:1802–1811.Google Scholar

Oktay, K, Harvey, BE, Partridge, AH et al. Fertility preservation in patients with cancer: ASCO Clinical Practice Guideline Update. J Clin Oncol, 2018;JCO.2018.78.191.Google Scholar

National Institute for Health and Care Excellence. Fertility problems: assessment and treatment. 2013; Available from: www.nice.org.uk/guidance/cg156/chapter/Recommendations#people-with-cancer-who-wish-to-preserve-fertilityGoogle Scholar

Liu, Z, Nie, YH, Zhang, CC et al. Generation of macaques with sperm derived from juvenile monkey testicular xenografts. Cell Res, 2016;26:139–142.Google Scholar

Honaramooz, A, Snedaker, A, Boiani, M et al. Sperm from neonatal mammalian testes grafted in mice. Nature, 2002;418:778–781.Google Scholar

Rathi, R, Zeng, W, Megee, S et al. Maturation of testicular tissue from infant monkeys after xenografting into mice. Endocrinology, 2008;149:5288–5296.Google Scholar

Honaramooz, A, Li, M-W, Penedo, MCT, Meyers, S, Dobrinski, I. Accelerated maturation of primate testis by xenografting into mice. Biol Reprod, 2004;70:1500–1503.CrossRefGoogle ScholarPubMed

Jahnukainen, K, Ehmcke, J, Nurmio, M, Schlatt, S. Autologous ectopic grafting of cryopreserved testicular tissue preserves the fertility of prepubescent monkeys that receive sterilizing cytotoxic therapy. Cancer Res, 2012;72:5174–5178.Google Scholar

Wistuba, J, Luetjens, CM, Wesselmann, R et al. Meiosis in autologous ectopic transplants of immature testicular tissue grafted to callithrix jacchus. Biol Reprod, 2006;74:706–713.CrossRefGoogle ScholarPubMed

Sato, Y, Taniguchi, M. Studying spermatogenesis by using In vivo and In vitro models: advantages and disadvantages of these models for practical use. J Vet Sci Technol, 2012;03:1–8.Google Scholar

Vermeulen, M, Poels, J, Michele, F de, Rieux, A des, Wyns, C. Restoring fertility with cryopreserved prepubertal testicular tissue: perspectives with hydrogel encapsulation, nanotechnology, and bioengineered scaffolds. Ann Biomed Eng, 2017;45:1770–1781.Google Scholar

Luetjens, MC, Stukenborg, J-B, Nieschlag, E, Simoni, M, Wistuba, J. Complete spermatogenesis in orthotopic but not in ectopic transplants of autologously grafted marmoset testicular tissue. Endocrinology, 2008;149:1736–1747.Google Scholar

Saen, D Van, Goossens, E, Block, G De, Tournaye, H. Regeneration of spermatogenesis by grafting testicular tissue or injecting testicular cells into the testes of sterile mice: a comparative study.Fertil Steril, 2009;91:2264–2272.Google Scholar

Schlatt, S, Honaramooz, A, Ehmcke, J et al. Limited survival of adult human testicular tissue as ectopic xenograft. Hum Reprod, 2006;21:384–389.Google Scholar

Goossens, E, Geens, M, Block, G De, Tournaye, H. Spermatogonial survival in long-term human prepubertal xenografts. Fertil Steril, 2008;90:2019–2022.Google Scholar

Yu, J, Cai, Z-M, Wan, H-J et al. Development of neonatal mouse and fetal human testicular tissue as ectopic grafts in immunodeficient mice. Asian J Androl, 2006;8:393–403.Google Scholar

Mitchell, RT, Saunders, PTK, Childs, AJ et al. Xenografting of human fetal testis tissue: a new approach to study fetal testis development and germ cell differentiation. Hum Reprod, 2010;25:2405–2414.Google Scholar

Lo, KC, Yildiz, C, Zhu, Y et al. Human fetal testicular tissue xenotransplantation: a platform to study the effect of gonadotropins on human germ cell development in utero.J Urol, 2015;194:585–591.Google Scholar

Saen, D Van, Goossens, E, Haentjens, P, Baert, Y, Tournaye, H. Exogenous administration of recombinant human FSH does not improve germ cell survival in human prepubertal xenografts. Reprod Biomed Online, 2013;26:286–298.Google Scholar

Poels, J, Langendonckt, A Van, Many, MC, Wese, FX, Wyns, C. Vitrification preserves proliferation capacity in human spermatogonia. Hum Reprod, 2013;28:578–589.Google Scholar

Saen, D Van, Goossens, E, Bourgain, C, Ferster, A, Tournaye, H. Meiotic activity in orthotopic xenografts derived from human postpubertal testicular tissue. Hum Reprod, 2011;26:282–293.Google Scholar

Poels, J, Abou-Ghannam, G, Herman, S et al. In search of better spermatogonial preservation by supplementation of cryopreserved human immature testicular tissue xenografts with N-acetylcysteine and testosterone. Front Surg, 2014;1:1–9.Google Scholar

Yokonishi, T, Sato, T, Katagiri, K et al. In vitro reconstruction of mouse seminiferous tubules supporting germ cell differentiation. Biol Reprod, 2013;89:1–6.Google Scholar

Mincheva, M, Sandhowe-Klaverkamp, R, Wistuba, J et al. Reassembly of adult human testicular cells: can testis cord-like structures be created in vitro? Mol Hum Reprod, 2018;24:55–63.Google Scholar

Gassei, K, Ehmcke, J, Wood, MA, Walker, WH, Schlatt, S. Immature rat seminiferous tubules reconstructed in vitro express markers of Sertoli cell maturation after xenografting into nude mouse hosts. Mol Hum Reprod, 2010;16:97–110.Google Scholar

Kita, K, Watanabe, T, Ohsaka, K et al. Production of functional spermatids from mouse germline stem cells in ectopically reconstituted seminiferous tubules. Biol Reprod, 2007;76:211–217.CrossRefGoogle ScholarPubMed

Zhou, Q, Wang, M, Yuan, Y et al. Complete meiosis from embryonic stem cell-derived germ cells in vitro. Cell Stem Cell, 2016;18:330–340.CrossRefGoogle ScholarPubMed

Ishikura, Y, Yabuta, Y, Ohta, H et al. In vitro derivation and propagation of spermatogonial stem cell activity from mouse pluripotent stem cells. Cell Rep, 2016;17:2789–2804.Google Scholar

Irie, N, Weinberger, L, Tang, WWC et al. SOX17 is a critical specifier of human primordial germ cell fate. Cell, 2015;160:253–268.Google Scholar

Park, TS, Galic, Z, Conway, AE et al. Derivation of primordial germ cells from human embryonic and induced pluripotent stem cells is significantly improved by coculture with human fetal gonadal cells.Stem Cells, 2009;27:783–795.Google Scholar

Vassena, R, Heindryckx, B, Peco, R et al. Genome engineering through CRISPR/Cas9 technology in the human germline and pluripotent stem cells. Hum Reprod Update, 2016;22:411–419.Google Scholar

Hutka M, Smith LB, Goossens E et al. Exogenous gonadotrophin stimulation induces partial maturation of human sertoli cells in a testicular xenotransplantation model for fertility preservation. J Clin Med, 2020;9:266.Google Scholar

Ntemou E, Kadam P, Van Saen D et al. Complete spermatogenesis in intratesticular testis tissue xenotransplants from immature non-human primate. Hum Reprod, 2019;34:403–413.Google Scholar

Goossens E, Jahnukainen K, Mitchell RT et al. Fertility preservation in boys: recent developments and new insights. Hum Reprod Open, 2020;3:hoaa016.Google Scholar

Braye A, Tournaye H, Goossens E. Setting up a cryopreservation programme for immature testicular tissue: lessons learned after more than 15 years of experience. Clin Med Insights Reprod Health, 2019;13:1179558119886342.Google Scholar

Fayomi AP, Peters K, Sukhwani M et al. Autologous grafting of cryopreserved prepubertal rhesus testis produces sperm and offspring. Science, 2019;363:1314–1319.Google Scholar

Mincheva M, Wistuba J, Brenker C et al. Challenging human somatic testicular cell reassembly by protein kinase inhibition-setting up a functional in vitro test system. Sci Rep, 2020;10:8935.Google Scholar

Landis, NT. Pharmacy technician helps cancer patients look good. Am J Health Syst Pharm, 1999;56(3):208.Google Scholar

Sant, M, Aareleid, T, Berrino, F et al. EUROCARE-3: survival of cancer patients diagnosed 1990–94–results and commentary. Ann Oncol, 2003;14(Suppl5):v61–118.Google Scholar

Garcia, JM, Li, H, Mann, D et al. Hypogonadism in male patients with cancer. Cancer, 2006;106(12):2583–2591.Google Scholar

Rajagopal, A, Vassilopoulou-Sellin, R, Palmer, JL, Kaur, G, Bruera, E. Symptomatic hypogonadism in male survivors of cancer with chronic exposure to opioids. Cancer, 2004;100(4):851–858.Google Scholar

Tisdale, MJ. Cachexia in cancer patients. Nat Rev Cancer, 2002;2(11):862–871.Google Scholar

Pfitzenmaier, J, Vessella, R, Higano, CS et al. Elevation of cytokine levels in cachectic patients with prostate carcinoma. Cancer, 2003;97(5):1211–1216.Google Scholar

Watson, ME, Newman, RJ, Payne, AM, Abdelrahim, M, Francis, GL. The effect of macrophage conditioned media on Leydig cell function. Ann Clin Lab Sci, 1994;24(1):84–95.Google Scholar

Turnbull, AV, Rivier, C. Inhibition of gonadotropin-induced testosterone secretion by the intracerebroventricular injection of interleukin-1 beta in the male rat. Endocrinology, 1997;138(3):1008–1013.Google Scholar

Afane, M, Dubost, JJ, Sauvezie, B et al. Modulation of Leydig cell testosterone production by secretory products of macrophages. Andrologia, 1998;30(2):71–78.Google Scholar

Kluge, M, Schussler, P, Uhr, M, Yassouridis, A, Steiger, A. Ghrelin suppresses secretion of luteinizing hormone in humans. J Clin Endocrinol Metab, 2007;92(8):3202–3205.Google Scholar

Lanfranco, F, Bonelli, L, Baldi, M et al. Acylated ghrelin inhibits spontaneous luteinizing hormone pulsatility and responsiveness to naloxone but not that to gonadotropin-releasing hormone in young men: evidence for a central inhibitory action of ghrelin on the gonadal axis. J Clin Endocrinol Metab, 2008;93(9):3633–3639.Google Scholar

Burney, BO, Garcia, JM. Hypogonadism in male cancer patients. J Cachexia Sarcopenia Muscle, 2012;3(3):149–155.Google Scholar

Fraser, LA, Morrison, D, Morley-Forster, P et al. Oral opioids for chronic non-cancer pain: higher prevalence of hypogonadism in men than in women. Exp Clin Endocrinol Diabetes, 2009;117(1):38–43.Google Scholar

Mendelson, JH, Ellingboe, J, Judson, BA, Goldstein, A. Plasma testosterone and luteinizing hormone levels during levo-alpha-acetylmethadol maintenance and withdrawal. Clin Pharmacol Ther, 1984;35(4):545–547.Google Scholar

Howell, SJ, Radford, JA, Ryder, WD, Shalet, SM. Testicular function after cytotoxic chemotherapy: evidence of Leydig cell insufficiency. J Clin Oncol, 1999;17(5):1493–1498.Google Scholar

Stuart, NS, Woodroffe, CM, Grundy, R, Cullen, MH. Long-term toxicity of chemotherapy for testicular cancer–the cost of cure. Br J Cancer, 1990;61(3):479–484.Google Scholar

Dueland, S, Guren, MG, Olsen, DR, Poulsen, JP, Magne Tveit, K. Radiation therapy induced changes in male sex hormone levels in rectal cancer patients. Radiother Oncol, 2003;68(3):249–253.Google Scholar

Oakberg, EF. Sensitivity and time of degeneration of spermatogenic cells irradiated in various stages of maturation in the mouse. Radiat Res, 1955;2(4):369–391.Google Scholar

Meistrich, ML, Finch, M, da Cunha, MF, Hacker, U, Au, WW. Damaging effects of fourteen chemotherapeutic drugs on mouse testis cells. Cancer Res, 1982;42(1):122–131.Google Scholar

Wallace, WH, Anderson, RA, Irvine, DS. Fertility preservation for young patients with cancer: who is at risk and what can be offered? Lancet Oncol, 2005;6(4):209–218.Google Scholar

Meistrich, ML. Effects of chemotherapy and radiotherapy on spermatogenesis in humans. Fertil Steril, 2013;100(5):1180–1186.Google Scholar

Mariani, S, Basciani, S, Fabbri, A et al. Severe oligozoospermia in a young man with chronic myeloid leukemia on long-term treatment with imatinib started before puberty. Fertil Steril, 2011;95(3):1120e1115–1127.Google Scholar

Seshadri, T, Seymour, JF, McArthur, GA. Oligospermia in a patient receiving imatinib therapy for the hypereosinophilic syndrome. N Engl J Med, 2004;351(20):2134–2135.Google Scholar

Borgmann-Staudt, A, Rendtorff, R, Reinmuth, S et al. Fertility after allogeneic haematopoietic stem cell transplantation in childhood and adolescence. Bone Marrow Transplant, 2012;47(2):271–276.Google Scholar

Meistrich, ML, Wilson, G, Mathur, K et al. Rapid recovery of spermatogenesis after mitoxantrone, vincristine, vinblastine, and prednisone chemotherapy for Hodgkin’s disease. J Clin Oncol, 1997;15(12):3488–3495.Google Scholar

Lass, A, Akagbosu, F, Abusheikha, N et al. A programme of semen cryopreservation for patients with malignant disease in a tertiary infertility centre: lessons from 8 years’ experience. Hum Reprod, 1998;13(11):3256–3261.Google Scholar

Ragni, G, Somigliana, E, Restelli, L et al.Sperm banking and rate of assisted reproduction treatment: insights from a 15-year cryopreservation program for male cancer patients. Cancer, 2003;97(7):1624–1629.Google Scholar

Oktay, K, Harvey, BE, Partridge, AH et al. Fertility preservation in patients with cancer: ASCO clinical practice guideline update. J Clin Oncol, 2018;36(19):1994–2001.Google Scholar

Zebrack, BJ, Casillas, J, Nohr, L, Adams, H, Zeltzer, LK. Fertility issues for young adult survivors of childhood cancer. Psychooncology, 2004;13(10):689–699.Google Scholar

Schover, LR, Brey, K, Lichtin, A, Lipshultz, LI, Jeha, S. Knowledge and experience regarding cancer, infertility, and sperm banking in younger male survivors. J Clin Oncol, 2002;20(7):1880–1889.Google Scholar

Schover, LR, Rybicki, LA, Martin, BA, Bringelsen, KA. Having children after cancer. A pilot survey of survivors’ attitudes and experiences. Cancer, 1999;86(4):697–709.Google Scholar

Schover, LR, Brey, K, Lichtin, A, Lipshultz, LI, Jeha, S. Oncologists’ attitudes and practices regarding banking sperm before cancer treatment. J Clin Oncol, 2002;20(7):1890–1897.Google Scholar

Glaser, AW, Phelan, L, Crawshaw, M, Jagdev, S, Hale, J. Fertility preservation in adolescent males with cancer in the United Kingdom: a survey of practice. Arch Dis Child, 2004;89(8):736–737.Google Scholar

Heath, JA, Stern, CJ. Fertility preservation in children newly diagnosed with cancer: existing standards of practice in Australia and New Zealand. Med J Aust, 2006;185(10):538–541.Google Scholar

Kelleher, S, Wishart, SM, Liu, PY et al. Long-term outcomes of elective human sperm cryostorage. Hum Reprod, 2001;16(12):2632–2639.Google Scholar

Blackhall, FH, Atkinson, AD, Maaya, MB et al. Semen cryopreservation, utilisation and reproductive outcome in men treated for Hodgkin’s disease. Br J Cancer, 2002;87(4):381–384.Google Scholar

Agarwal, A, Ranganathan, P, Kattal, N et al. Fertility after cancer: a prospective review of assisted reproductive outcome with banked semen specimens. Fertil Steril, 2004;81(2):342–348.Google Scholar

Forbes, CM, Flannigan, R, Schlegel, PN. Spermatogonial stem cell transplantation and male infertility: Current status and future directions. Arab J Urol, 2018;16(1):171–180.Google Scholar

Sandeman, TF. The effects of x irradiation on male human fertility. Br J Radiol, 1966;39(468):901–907.Google Scholar

Castillo, LA, Craft, AW, Kernahan, J, Evans, RG, Aynsley-Green, A. Gonadal function after 12-Gy testicular irradiation in childhood acute lymphoblastic leukaemia. Med Pediatr Oncol, 1990;18(3):185–189.Google Scholar

Shalet, SM, Tsatsoulis, A, Whitehead, E, Read, G. Vulnerability of the human Leydig cell to radiation damage is dependent upon age. J Endocrinol, 1989;120(1):161–165.Google Scholar

Marmor, D, Grob-Menendez, F, Duyck, F, Delafontaine, D. Very late return of spermatogenesis after chlorambucil therapy: case reports. Fertil Steril, 1992;58(4):845–846.Google Scholar

Schmidt, KL, Larsen, E, Bangsboll, S et al. Assisted reproduction in male cancer survivors: fertility treatment and outcome in 67 couples. Hum Reprod. 2004;19(12):2806–2810.Google Scholar

Kader, HA, Rostom, AY. Follicle stimulating hormone levels as a predictor of recovery of spermatogenesis following cancer therapy. Clin Oncol (R Coll Radiol), 1991;3(1):37–40.Google Scholar

Ramasamy, R, Lin, K, Gosden, LV et al. High serum FSH levels in men with nonobstructive azoospermia does not affect success of microdissection testicular sperm extraction. Fertil Steril, 2009;92(2):590–593.Google Scholar

Alfano, M, Ventimiglia, E, Locatelli, I et al. Anti-Mullerian hormone-to-testosterone ratio is predictive of positive sperm retrieval in men with idiopathic non-obstructive azoospermia. Sci Rep, 2017;7(1):17638.Google Scholar

Zhang, S, Du, J, Tian, R et al. Assessment of the use of contrast enhanced ultrasound in guiding microdissection testicular sperm extraction in nonobstructive azoospermia. BMC Urol, 2018;18(1):48.Google Scholar

Kop, PA, van Wely, M, Mol, BW et al. Intrauterine insemination or intracervical insemination with cryopreserved donor sperm in the natural cycle: a cohort study. Hum Reprod, 2015;30(3):603–607.Google Scholar

Hourvitz, A, Goldschlag, DE, Davis, OK et al. Intracytoplasmic sperm injection (ICSI) using cryopreserved sperm from men with malignant neoplasm yields high pregnancy rates. Fertil Steril, 2008;90(3):557–563.Google Scholar

Dohle, GR. Male infertility in cancer patients: Review of the literature. Int J Urol, 2010;17(4):327–331.Google Scholar

Botchan, A, Karpol, S, Lehavi, O et al. Preservation of sperm of cancer patients: extent of use and pregnancy outcome in a tertiary infertility center. Asian J Androl, 2013;15(3):382–386.Google Scholar

Spermon, JR, Ramos, L, Wetzels, AM et al. Sperm integrity pre- and post-chemotherapy in men with testicular germ cell cancer. Hum Reprod, 2006;21(7):1781–1786.Google Scholar

Berthelsen, JG, Skakkebaek, NE. Gonadal function in men with testis cancer. Fertil Steril, 1983;39(1):68–75.Google Scholar

Sanger, WG, Armitage, JO, Schmidt, MA. Feasibility of semen cryopreservation in patients with malignant disease. JAMA, 1980;244(8):789–790.Google Scholar

Viviani, S, Ragni, G, Santoro, A et al. Testicular dysfunction in Hodgkin’s disease before and after treatment. Eur J Cancer, 1991;27(11):1389–1392.Google Scholar

Khalifa, E, Oehninger, S, Acosta, AA et al. Successful fertilization and pregnancy outcome in in-vitro fertilization using cryopreserved/thawed spermatozoa from patients with malignant diseases. Hum Reprod, 1992;7(1):105–108.Google Scholar

Padron, OF, Sharma, RK, Thomas, A, Jr., Agarwal, A. Effects of cancer on spermatozoa quality after cryopreservation: a 12-year experience. Fertil Steril, 1997;67(2):326–331.Google Scholar

Schrader, M, Muller, M, Sofikitis, N et al. “Onco-tese”: testicular sperm extraction in azoospermic cancer patients before chemotherapy-new guidelines? Urology, 2003;61(2):421–425.Google Scholar

Abumelha, S, Poullis, C, Almashat, F et al. Microdissection onco-TESE in men with azoospermia and cancer. European Urology, 2016;Supplement 15(3):e185.Google Scholar

Baniel, J, Sella, A. Sperm extraction at orchiectomy for testis cancer. Fertil Steril, 2001;75(2):260–262.Google Scholar

Carmignani, L, Gadda, F, Gazzano, G et al. Testicular sperm extraction in cancerous testicle in patients with azoospermia: a case report. Hum Reprod, 2007;22(4):1068–1072.Google Scholar

Descombe, L, Chauleur, C, Gentil-Perret, A et al. Testicular sperm extraction in a single cancerous testicle in patients with azoospermia: a case report. Fertil Steril, 2008;90(2):443e441–444.Google Scholar

Kohn, FM, Schroeder-Printzen, I, Weidner, W et al. Testicular sperm extraction in a patient with metachronous bilateral testicular cancer. Hum Reprod, 2001;16(11):2343–2346.Google Scholar

De Mas, P, Daudin, M, Vincent, MC et al. Increased aneuploidy in spermatozoa from testicular tumour patients after chemotherapy with cisplatin, etoposide and bleomycin. Hum Reprod, 2001;16(6):1204–1208.Google Scholar

Rives, N, Walschaerts, M, Setif, V et al. Sperm aneuploidy after testicular cancer treatment: data from a prospective multicenter study performed within the French Centre d’Etude et de Conservation des Oeufs et du Sperme network. Fertil Steril, 2017;107(3):580–588 e581.Google Scholar

Smit, M, van Casteren, NJ, Wildhagen, MF, Romijn, JC, Dohle, GR. Sperm DNA integrity in cancer patients before and after cytotoxic treatment. Hum Reprod, 2010;25(8):1877–1883.Google Scholar

Brydoy, M, Fossa, SD, Klepp, O et al. Paternity following treatment for testicular cancer. J Natl Cancer Inst, 2005;97(21):1580–1588.Google Scholar

Ohl, DA, Denil, J, Bennett, CJ et al. Electroejaculation following retroperitoneal lymphadenectomy. J Urol, 1991;145(5):980–983.Google Scholar

Hultling, C, Rosenlund, B, Tornblom, M et al. Transrectal electroejaculation in combination with in-vitro fertilization: an effective treatment of anejaculatory infertility after testicular cancer. Hum Reprod, 1995;10(4):847–850.Google Scholar

Chung, PH, Palermo, G, Schlegel, PN et al. The use of intracytoplasmic sperm injection with electroejaculates from anejaculatory men. Hum Reprod, 1998;13(7):1854–1858.Google Scholar

Rosenlund, B, Sjoblom, P, Tornblom, M, Hultling, C, Hillensjo, T. In-vitro fertilization and intracytoplasmic sperm injection in the treatment of infertility after testicular cancer. Hum Reprod, 1998;13(2):414–418.Google Scholar

Schlegel, PN. Testicular sperm extraction: microdissection improves sperm yield with minimal tissue excision. Hum Reprod, 1999;14(1):131–135.Google Scholar

Schoor, RA, Elhanbly, S, Niederberger, CS, Ross, LS. The role of testicular biopsy in the modern management of male infertility. J Urol, 2002;167(1):197–200.Google Scholar

Tsujimura, A, Matsumiya, K, Miyagawa, Y et al. Conventional multiple or microdissection testicular sperm extraction: a comparative study. Hum Reprod, 2002;17(11):2924–2929.Google Scholar

Su, LM, Palermo, GD, Goldstein, M et al. Testicular sperm extraction with intracytoplasmic sperm injection for nonobstructive azoospermia: testicular histology can predict success of sperm retrieval. J Urol, 1999;161(1):112–116.Google Scholar

Ramasamy, R, Schlegel, PN. Microdissection testicular sperm extraction: effect of prior biopsy on success of sperm retrieval. J Urol, 2007;177(4):1447–1449.Google Scholar

Ramasamy, R, Yagan, N, Schlegel, PN. Structural and functional changes to the testis after conventional versus microdissection testicular sperm extraction. Urology, 2005;65(6):1190–1194.Google Scholar

Hsiao, W, Stahl, PJ, Osterberg, EC et al. Successful treatment of postchemotherapy azoospermia with microsurgical testicular sperm extraction: the Weill Cornell experience. J Clin Oncol, 2011;29(12):1607–1611.Google Scholar

Damani, MN, Master, V, Meng, MV et al. Postchemotherapy ejaculatory azoospermia: fatherhood with sperm from testis tissue with intracytoplasmic sperm injection. J Clin Oncol, 2002;20(4):930–936.Google Scholar

Meseguer, M, Garrido, N, Remohi, J et al. Testicular sperm extraction (TESE) and ICSI in patients with permanent azoospermia after chemotherapy. Hum Reprod, 2003;18(6):1281–1285.Google Scholar

Daniels, K. Donor Insemination. Oxford: Oxford University Press, 2002.Google Scholar

Ethics Committee of American Society for Reproductive Medicine. Informing offspring of their conception by gamete or embryo donation: a committee opinion. Fertil Steril, 2013;100(1):45–49.Google Scholar

Ethics ETFo. Law. III. Gamete and embryo donation. Hum Reprod, 2002;17(5):1407–1408.Google Scholar

Boivin, J, Appleton, TC, Baetens, P et al. Guidelines for counselling in infertility: outline version. Hum Reprod, 2001;16(6):1301–1304.Google Scholar

Covington, SN. The role of the mental health professional in reproductive medicine. Fertil Steril, 1995;64(5):895–897.Google Scholar

Greenfeld, DA. Does psychological support and counseling reduce the stress experienced by couples involved in assisted reproductive technology? J Assist Reprod Genet, 1997;14(4):186–188.Google Scholar

Applegarth, L. The psychological aspects of infertility. In Keye, W, Chang, R, Rebar, R, Soules, M (eds.) Infertility: Evaluation and Treatment. Vol 25–41. Philadelphia: Saunders. 1995.Google Scholar

Leiblum, S, Greenfeld, D. The course of infertility: immediate and long-term reactions. In Leiblum, S (ed.) Infertility: Psychological Issues and Counseling Strategies. New York: Wiley. 1997, 83–92.Google Scholar

Greenfeld, D. Recipient counseling for oocyte donation. In Burns, L, Covington, S (eds.) Infertility Counseling: A Comprehensive Handbook for Clinicians. New York: Parthenon Publishing Group. 1999, 435–455.Google Scholar

Frith, L. Beneath the rhetoric: the role of rights in the practice of non-anonymous gamete donation. Bioethics, 2001;15(5–6):473–484.Google Scholar

Mahlstedt, PP, Greenfeld, DA. Assisted reproductive technology with donor gametes: the need for patient preparation. Fertil Steril, 1989;52(6):908–914.Google Scholar

Gong, D, Liu, YL, Zheng, Z, Tian, YF, Li, Z. An overview on ethical issues about sperm donation. Asian J Androl, 2009;11(6):645–652.Google Scholar

Thorn, P. Recipient counseling for donor insemination. In Covington, S, Burns, L (eds.) Infertility Counseling: A Comprehensive Handbook for Clinicians. 2nd ed. New York: Cambridge University Press. 2006.Google Scholar

Ethics Committee of the American Society for Reproductive Medicine. Using family members as gamete donors or surrogates. Fertil Steril, 2012;98(4):797–803.Google Scholar

Applegarth, L, Grill, E. Psychological issues in reproductive disorders. In Chan, P, Goldstein, M, Rosenwaks, Z (eds.) Reproductive Medicine Secrets. Philadelphia PA: Hanley and Belfus Medical Publishers. 2004, 342–362.Google Scholar

Cooper, S, Glazer, E. Choosing Assisted Reproduction. Indianapolis: Perspectives Press. 1998.Google Scholar

Daniels, KR, Thorn, P. Sharing information with donor insemination offspring. A child-conception versus a family-building approach. Hum Reprod, 2001;16(9):1792–1796.Google Scholar

McGee, G, Brakman, SV, Gurmankin, AD. Gamete donation and anonymity: disclosure to children conceived with donor gametes should not be optional. Hum Reprod, 2001;16(10):2033–2036.Google Scholar

McWhinnie, A. Gamete donation and anonymity: should offspring from donated gametes continue to be denied knowledge of their origins and antecedents? Hum Reprod, 2001;16(5):807–817.Google Scholar

Broderick, P, Walker, I. Information access and donated gametes: how much do we know about who wants to know? Hum Reprod, 1995;10(12):3338–3341.Google Scholar

Klock, SC. The controversy surrounding privacy or disclosure among donor gamete recipients. J Assist Reprod Genet, 1997;14(7):378–380.Google Scholar

Shenfield, F, Steele, SJ. What are the effects of anonymity and secrecy on the welfare of the child in gamete donation? Hum Reprod, 1997;12(2):392–395.Google Scholar

Haimes, E. Theory and methodology in the analysis of the policy process: a case study of the Warnock committee on human fertilization and embryology. In Hill, M (ed.) New Agendas in the Study of the Policy Process. Hemel Hempstead: Wheatsheaf. 1993, 152–175.Google Scholar

Pennings, G. The “double track” policy for donor anonymity. Hum Reprod, 1997;12(12):2839–2844.Google Scholar

Greenfeld, DA. The impact of disclosure on donor gamete participants: donors, intended parents and offspring. Curr Opin Obstet Gynecol, 2008;20(3):265–268.Google Scholar

Crenshaw, WB, Lichtenberg, JW. Child abuse and the limits of confidentiality: forewarning practices. Behav Sci Law, 1993;11(2):181–192.Google Scholar

American Society for Reproductive Medicine. Psychological assessment of gamete donors and recipients. Fertil Steril, 2004;82(Suppl 1):S18–S19.Google Scholar

Hammarberg, K, Carmichael, M, Tinney, L, Mulder, A. Gamete donors’ and recipients’ evaluation of donor counselling: a prospective longitudinal cohort study. Aust N Z J Obstet Gynaecol, 2008;48(6):601–606.Google Scholar

Boggio, A. Italy enacts new law on medically assisted reproduction. Hum Reprod, 2005;20(5):1153–1157.Google Scholar

Boggio, A. The legalisation of gamete donation in Italy. Eur J Health Law, 2017;24(1):85–104.Google Scholar

Gottlieb, C, Lalos, O, Lindblad, F. Disclosure of donor insemination to the child: the impact of Swedish legislation on couples’ attitudes. Hum Reprod, 2000;15(9):2052–2056.Google Scholar

Cook, R, Golombok, S, Bish, A, Murray, C. Disclosure of donor insemination: parental attitudes. Am J Orthopsychiatry, 1995;65(4):549–559.Google Scholar

Lindblad, F, Gottlieb, C, Lalos, O. To tell or not to tell–what parents think about telling their children that they were born following donor insemination. J Psychosom Obstet Gynaecol, 2000;21(4):193–203.Google Scholar

Nachtigall, RD, Becker, G, Wozny, M. The effects of gender-specific diagnosis on men’s and women’s response to infertility. Fertil Steril, 1992;57(1):113–121.Google Scholar

Molock, S. Racial cultural and religious issues in infertility counseling. In Burns, L, Covinton, S (eds.) Infertility Counseling: A Comprehensive Handbook for Clinicians. Pearl River, NY: Parthenon Publishing Group. 1999, 249–265.Google Scholar

McCormick, RA. Surrogacy: a catholic perspective. Creighton Law Rev, 1992;25(5):1617–1625.Google Scholar

Sallam, HN, Sallam, NH. Religious aspects of assisted reproduction. Facts Views Vis Obgyn, 2016;8(1):33–48.Google Scholar

Golombok, S, Lycett, E, MacCallum, F et al. Parenting infants conceived by gamete donation. J Fam Psychol, 2004;18(3):443–452.Google Scholar

Lycett, E, Daniels, K, Curson, R, Golombok, S. School-aged children of donor insemination: a study of parents’ disclosure patterns. Hum Reprod, 2005;20(3):810–819.Google Scholar

Shehab, D, Duff, J, Pasch, LA et al. How parents whose children have been conceived with donor gametes make their disclosure decision: contexts, influences, and couple dynamics. Fertil Steril, 2008;89(1):179–187.Google Scholar

Jadva, V, Freeman, T, Kramer, W, Golombok, S. The experiences of adolescents and adults conceived by sperm donation: comparisons by age of disclosure and family type. Hum Reprod, 2009;24(8):1909–1919.Google Scholar

Lycett, E, Daniels, K, Curson, R, Golombok, S. Offspring created as a result of donor insemination: a study of family relationships, child adjustment, and disclosure. Fertil Steril, 2004;82(1):172–179.Google Scholar

Golombok, S, Brewaeys, A, Giavazzi, MT et al. The European study of assisted reproduction families: the transition to adolescence. Hum Reprod, 2002;17(3):830–840.Google Scholar

Golombok, S, Readings, J, Blake, L et al. Children conceived by gamete donation: psychological adjustment and mother-child relationships at age 7. J Fam Psychol, 2011;25(2):230–239.Google Scholar

Fossa, SD, Aass, N, Molne, K. Is routine pre-treatment cryopreservation of semen worthwhile in the management of patients with testicular cancer? Br J Urol, 1989;64(5):524–529.Google Scholar