Book contents
- Frontmatter
- Contents
- List of contributors
- Preface: Focus on the serotonin transporter
- 1 Presynaptic adaptive responses to constitutive versus adult pharmacologic inhibition of serotonin uptake
- 2 Cellular and molecular alterations in animal models of serotonin transporter disruption: a comparison between developmental and adult stages
- 3 Developmental roles for the serotonin transporter
- 4 SERT models of emotional dysregulation
- 5 The serotonin transporter and animal models of depression
- 6 The serotonin transporter knock-out rat: a review
- 7 Wistar–Zagreb 5HT rats: a rodent model with constitutional upregulation/downregulation of serotonin transporter
- 8 The role of the serotonin transporter in reward mechanisms
- 9 Modeling SERT × BDNF interactions in brain disorders: single BDNF gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities in serotonin transporter knock-out mice
- 10 Primate models in serotonin transporter research
- 11 The role of serotonin transporter in modeling psychiatric disorders: focus on depression, emotion regulation, and the social brain
- Index
- Plate section
- References
11 - The role of serotonin transporter in modeling psychiatric disorders: focus on depression, emotion regulation, and the social brain
Published online by Cambridge University Press: 06 July 2010
- Frontmatter
- Contents
- List of contributors
- Preface: Focus on the serotonin transporter
- 1 Presynaptic adaptive responses to constitutive versus adult pharmacologic inhibition of serotonin uptake
- 2 Cellular and molecular alterations in animal models of serotonin transporter disruption: a comparison between developmental and adult stages
- 3 Developmental roles for the serotonin transporter
- 4 SERT models of emotional dysregulation
- 5 The serotonin transporter and animal models of depression
- 6 The serotonin transporter knock-out rat: a review
- 7 Wistar–Zagreb 5HT rats: a rodent model with constitutional upregulation/downregulation of serotonin transporter
- 8 The role of the serotonin transporter in reward mechanisms
- 9 Modeling SERT × BDNF interactions in brain disorders: single BDNF gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities in serotonin transporter knock-out mice
- 10 Primate models in serotonin transporter research
- 11 The role of serotonin transporter in modeling psychiatric disorders: focus on depression, emotion regulation, and the social brain
- Index
- Plate section
- References
Summary
ABSTRACT
Depression is an etiologically and clinically heterogeneous syndrome frequently co-occurring in a wide spectrum of psychiatric disorders. Characterized by a wide range of symptoms that reflect alterations in cognitive, emotional, and psychomotor processes, this syndrome is moderately to highly heritable, and caused by interaction of genes and adverse life events. Differentiation of risk-related psychobiological and neuropsychological markers is essential for the dissection of the complex genetic susceptibility to depression and comorbid disorders. A brain serotonin (5-HT) system dysfunction is thought to be involved in the pathogenesis of depression by modulating cognitive dysfunction, stress response, neuroadaptive processes, and resulting pervasive emotional disturbance. A regulatory variation in the gene encoding the 5-HT transporter (5-HTT), the master controller in the fine-tuning of 5-HT signaling, is not only associated with anxiety-related traits, but also modifies the risk of developing disorders of emotion regulation. Yet the neural and molecular mechanisms underlying gene × environment interaction are poorly understood. This paper investigates innate variability of brain 5-HTT function from an interdisciplinary perspective blending behavioral genetics and cognitive neuroscience. Following an appraisal of imaging neural correlates of genomic variation and epigenetic mechanisms as a strategy for psychiatric disorder risk assessment, future challenges for biosocial sciences in the perspective of the complex genetic architecture of emotional behavior and social interaction in non-human primates and humans are defined.
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- Chapter
- Information
- Experimental Models in Serotonin Transporter Research , pp. 308 - 352Publisher: Cambridge University PressPrint publication year: 2010
References
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