Skip to main content Accessibility help
×
Hostname: page-component-848d4c4894-4rdrl Total loading time: 0 Render date: 2024-06-20T11:12:33.511Z Has data issue: false hasContentIssue false

Chapter 8 - Management of Uterine Fibroids

from Section 2 - Menstrual Disorders

Published online by Cambridge University Press:  24 November 2021

Tahir Mahmood
Affiliation:
Victoria Hospital, Kirkcaldy
Charles Savona-Ventura
Affiliation:
University of Malta, Malta
Ioannis Messinis
Affiliation:
University of Thessaly, Greece
Sambit Mukhopadhyay
Affiliation:
Norfolk & Norwich University Hospital, UK
Get access

Summary

With a lifetime prevalence of up to 75%, uterine fibroids are the most common benign tumour of the female reproductive system. Fibroids present the most common indication for hysterectomy and are associated with high health-related costs. They can severely affect the quality of life of these women and may diminish fertility. This chapter provides an overview of the aetiology, prevalence, diagnosis and treatment options for uterine fibroids. As the reproductive phase is shifting ever further back into the life of a woman, conservative therapy options are becoming increasingly important.

Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2021

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Foth, D, Röhl, F-W, Friedrich, C. Symptoms of uterine myomas: data of an epidemiological study in Germany. Arch Gynecol Obstet 2017;295:415426.Google Scholar
Ahrendt, HJ, Tylkoski, H, Rabe, T. Prevalence of uterine myomas in women in Germany: data of an epidemiological study. Arch Gynecol Obstet 2016;293:12431253.CrossRefGoogle ScholarPubMed
Huyck, KL, Panhuysen, CIM, Cuenco, KT. The impact of race as a risk factor for symptom severity and age at diagnosis of uterine leiomyomata among affected sisters. Am J Obstet Gynecol 2008;198:168 e1168 e9.CrossRefGoogle ScholarPubMed
Pavone, D, Clemenza, S, Sorbi, F, et al. Epidemiology and risk factors of uterine fibroids. Best Pract Res Clin Obstet Gynaecol 2018;46:311.Google Scholar
Parker, WH. The utility of MRI for the surgical treatment of women with uterine fibroid tumors. Am J Obstet Gynecol 2012;206:3136.Google Scholar
Munro, MG, Critchley, HOD, Broder, MS. FIGO classification system (PALM-COEIN) for causes of abnormal uterine bleeding in nongravid women of reproductive age. Int J Gynaecol Obstet 2011;113:313.Google Scholar
Dubuisson, J. The current place of mini-invasive surgery in uterine leiomyoma management. J Gynecol Obstet Hum Reprod 2019;48:7781.Google Scholar
Bryant-Smith, AC, Lethaby, A, Farquhar, C, Hickey, M. Antifibrinolytics for heavy menstrual bleeding. Cochrane Database Syst Rev 2018;4:CD000249.Google Scholar
Qin, J, Yang, T, Kong, F, Zhou, Q. Oral contraceptive use and uterine leiomyoma risk: a meta-analysis based on cohort and case-control studies. Arch Gynecol Obstet 2013;288:139148.Google Scholar
Schreiber, CA, Teal, SB, Blumenthal, PD, Keder, LM, et al. Bleeding patterns for the Liletta® levonorgestrel 52 mg intrauterine system. Eur J Contracept Reprod Health Care 2018;23:116120.Google Scholar
Römer, TDK, Foth, D, Hadji, P, et al. Symptomatischer Uterus myomatosus. Zielgerichtete medikamentöse Therapie Frauenarzt 2017;6:497503.Google Scholar
Ali, M, Al-Hendy, A. Uterine fibroid therapy: the pharmacokinetic considerations. Expert Opin Drug Metab Toxicol 2018;14:887889.Google Scholar
Sinai Talaulikar, V. Medical therapy for fibroids: an overview. Best Pract Res Clin Obstet Gynaecol 2018;46:4856.CrossRefGoogle ScholarPubMed
Singh, SS, Belland, L. Contemporary management of uterine fibroids: focus on emerging medical treatments. Curr Med Res Opin 2015;31:112.CrossRefGoogle ScholarPubMed
Kamath, MS, Kalampokas, EE, Kalampokas, TE. Use of GnRH analogues pre-operatively for hysteroscopic resection of submucous fibroids: a systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol 2014;177:1118.Google Scholar
Donnez, J, Tomaszewski, J, Vázquez, F, et al. Ulipristal acetate versus leuprolide acetate for uterine fibroids. N Engl J Med 2012;366:421432.CrossRefGoogle ScholarPubMed
Donnez, J, Vázquez, F, Tomaszewski, J, et al. Long-term treatment of uterine fibroids with ulipristal acetate. Fertil Steril 2014;101:1565–73 e1–18.CrossRefGoogle ScholarPubMed
Rabe, T, Sanger, N, Ebert, AD, et al. Die Anwendung von Selektiven Progesteron-rezeptor-modulatoren (SPrms) zur medikamentösen behandlung von uterusmyomen: ulipristalacetat im Fokus. J Reproduktionsmed Endokrinol_Online 2017;14:113122.Google Scholar
Donnez, J, Donnez, O, Matule, D, et al. Long-term medical management of uterine fibroids with ulipristal acetate. Fertil Steril 2016;105:165173 e4.CrossRefGoogle ScholarPubMed
Donnez, J. Liver injury and ulipristal acetate: an overstated tragedy? Fertil Steril 2018;110:593595.CrossRefGoogle ScholarPubMed
Kriplani, A, Srivastava, A, Kulshrestha, V, et al. Efficacy of ormeloxifene versus oral contraceptive in the management of abnormal uterine bleeding due to uterine leiomyoma. J Obstet Gynaecol Res 2016;42:17441752.Google Scholar
Fauser, BC, Donnez, J, Bouchard, P, et al. Safety after extended repeated use of ulipristal acetate for uterine fibroids. PLoS One 2017;12:e0173523.CrossRefGoogle ScholarPubMed
AAGL Advancing Minimally Invasive Gynecology Worldwide. AAGL position statement: route of hysterectomy to treat benign uterine disease. J Minim Invasive Gynecol 2011;18:13.Google Scholar
Miskry, T, Magos, A. Randomized, prospective, double-blind comparison of abdominal and vaginal hysterectomy in women without uterovaginal prolapse. Acta Obstet Gynecol Scand 2003;82:351358.Google Scholar
Andres, MP, Borrelli, GM, Abrao, MS. Advances on minimally invasive approach for benign total hysterectomy: a systematic review. F1000Res 2017;6:1295.CrossRefGoogle ScholarPubMed
Taylan, E, Sahin, C, Zeybek, B, Akdemir, A. Contained morcellation: review of current methods and future directions. Front Surg 2017;4:15.CrossRefGoogle ScholarPubMed
Sesti, F, Ruggeri, V, Pietropolli, A, Piccione, E. Laparoscopically assisted vaginal hysterectomy versus vaginal hysterectomy for enlarged uterus. JSLS 2008;12:246251.Google Scholar
Cezar, C, Becker, S, di Spiezio Sardo, A. Laparoscopy or laparotomy as the way of entrance in myoma enucleation. Arch Gynecol Obstet 2017;296:709720.CrossRefGoogle ScholarPubMed
Young, M, Mikhail, LN. Uterine Fibroid Embolization. Treasure Island (FL): StatPearls, 2018.Google Scholar
Sridhar, D, Kohi, MP. Updates on MR-guided focused ultrasound for symptomatic uterine fibroids. Semin Intervent Radiol 2018;35:1722.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×