Skip to main content Accessibility help
×
Hostname: page-component-76fb5796d-r6qrq Total loading time: 0 Render date: 2024-04-27T02:12:50.068Z Has data issue: false hasContentIssue false

4 - Serotonergic dysfunction in bipolar disorder

Published online by Cambridge University Press:  05 May 2016

Jair C. Soares
Affiliation:
University of Texas Health Science Center, Houston
Allan H. Young
Affiliation:
King's College London
Get access

Summary

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Chapter
Information
Bipolar Disorders
Basic Mechanisms and Therapeutic Implications
, pp. 43 - 48
Publisher: Cambridge University Press
Print publication year: 2016

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Baldessarini, R.J., Leahy, L., Arcona, S., et al. Patterns of psychotropic drug prescription for U.S. patients with diagnoses of bipolar disorders. Psychiatr Serv. 2007;58(1):8591.CrossRefGoogle ScholarPubMed
Cannon, D.M., Ichise, M., Fromm, S.J., et al. Serotonin transporter binding in bipolar disorder assessed using [11C]DASB and positron emission tomography. Biol Psychiatry. 2006;60(3):207–17.CrossRefGoogle ScholarPubMed
Cho, H.J., Meira-Lima, I., Cordeiro, Q., et al. Population-based and family-based studies on the serotonin transporter gene polymorphisms and bipolar disorder: A systematic review and meta-analysis. Mol Psychiatry 2005;10(8):771–81.CrossRefGoogle ScholarPubMed
Chou, Y.H., Wang, S.J., Lin, C.L., Decreased brain serotonin transporter binding in the euthymic state of bipolar I but not bipolar II disorder: A SPECT study. Bipolar Disord. 2010;12(3):312–18.CrossRefGoogle Scholar
Cohn, J.B., Collins, G., Ashbrook, E., et al. A comparison of fluoxetine imipramine and placebo in patients with bipolar depressive disorder. Int Clin Psychopharmacol. 1989;4(4):313–22.CrossRefGoogle ScholarPubMed
Daray, F.M., Thommi, S.B., Ghaemi, S.N. The pharmacogenetics of antidepressant-induced mania: A systematic review and meta-analysis. Bipolar Disord. 2010;12(7):702–6.CrossRefGoogle Scholar
Dean, B. The neurobiology of bipolar disorder: Findings using human postmortem central nervous system tissue. Aust N Z J Psychiatry. 2004;38(3):135–40.CrossRefGoogle ScholarPubMed
Drevets, W.C., Frank, E., Price, J.C., et al. PET imaging of serotonin 1A receptor binding in depression. Biol Psychiatry. 1999;46(10):1375–87.CrossRefGoogle ScholarPubMed
Geyer, M.A. Serotonergic functions in arousal and motor activity. Behav Brain Res. 1996;73(1–2):31–5.Google ScholarPubMed
Ghaemi, S.N., Hsu, D.J., Thase, M.E., et al. Pharmacological treatment patterns at study entry for the first 500 STEP-BD participants. Psychiatr Serv. 2006;57(5):660–5.CrossRefGoogle ScholarPubMed
Goldberg, J.F., Nassir Ghaemi, S. Benefits and limitations of antidepressants and traditional mood stabilizers for treatment of bipolar depression. Bipolar Disord. 2005;7(Suppl 5):312.CrossRefGoogle ScholarPubMed
Lan, M.J., Hesselgrave, N., Ciarleglio, A., et al. Higher pretreatment 5-HT1A receptor binding potential in bipolar disorder depression is associated with treatment remission: a naturalistic treatment pilot PET study. Synapse. 2013;67(11):773–8.CrossRefGoogle ScholarPubMed
Lasky-Su, J.A., Faraone, S.V., Glatt, S.J., et al.Meta-analysis of the association between two polymorphisms in the serotonin transporter gene and affective disorders. Am J Med Genet B Neuropsychiatr Genet. 2005;133B(1):110–15.CrossRefGoogle ScholarPubMed
Lichtenberg, P., Shapira, B., Gillon, D., et al. Hormone responses to fenfluramine and placebo challenge in endogenous depression. Psychiatry Res. 1992;43(2):137–46.CrossRefGoogle ScholarPubMed
Macoveanu, J. Serotonergic modulation of reward and punishment: Evidence from pharmacological fMRI studies. Brain Res. 2014;1556:1927.CrossRefGoogle ScholarPubMed
Matthews, P.R., Harrison, P.J. A morphometric, immunohistochemical, and in situ hybridization study of the dorsal raphe nucleus in major depression, bipolar disorder, schizophrenia, and suicide. J Affect Disord. 2012;137(13):125–34.CrossRefGoogle ScholarPubMed
Meyer, J.S. 3,4-methylenedioxymethamphetamine (MDMA): current perspectives. Subst Abuse Rehabil. 2013;4:8399.CrossRefGoogle Scholar
Mitchell, P., Smythe, G., Parker, G., et al. Hormonal responses to fenfluramine in depressive subtypes. Br J Psychiatry. 1990;157:551–7.CrossRefGoogle ScholarPubMed
Miyazaki, K., Miyazaki, K.W.,Doya, K. The role of serotonin in the regulation of patience and impulsivity. Mol Neurobiol. 2012;45(2):213–24.CrossRefGoogle ScholarPubMed
Monti, J.M. Serotonin control of sleep-wake behavior. Sleep Med Rev. 2011;15(4):269–81.CrossRefGoogle ScholarPubMed
Mosienko, V., Beis, D., Pasqualetti, M., et al. Life without brain serotonin: Reevaluation of serotonin function with mice deficient in brain serotonin synthesis. Behav Brain Res. 2015;277C:7888.CrossRefGoogle Scholar
Narayan, V., Haddad, P.M. Antidepressant discontinuation manic states: a critical review of the literature and suggested diagnostic criteria. J Psychopharmacol. 2011;25(3):306–13.CrossRefGoogle Scholar
Neves, F.S., Silveira, G., Romano-Silva, M.A., et al. Is the 5-HTTLPR polymorphism associated with bipolar disorder or with suicidal behavior of bipolar disorder patients? Am J Med Genet B Neuropsychiatr Genet. 2008;147B(1):114–16.CrossRefGoogle ScholarPubMed
Nugent, A.C., Bain, E.E., Carlson, P.J., et al. Reduced post-synaptic serotonin type 1A receptor binding in bipolar depression. Eur Neuropsychopharmacol. 2013a;23(8):822–29.Google ScholarPubMed
Nugent, A.C., Carlson, P.J., Bain, E.E., et al. Mood stabilizer treatment increases serotonin type 1A receptor binding in bipolar depression. J Psychopharmacol. 2013b;27(10):894902.CrossRefGoogle ScholarPubMed
Nye, J.A., Purselle, D., Plisson, C., et al. Decreased brainstem and putamen SERT binding potential in depressed suicide attempters using [11C]-zient PET imaging. Depress Anxiety. 2013;30(10):902–7.Google ScholarPubMed
Oquendo, M.A., Hastings, R.S., Huang, Y.Y., et al. Brain serotonin transporter binding in depressed patients with bipolar disorder using positron emission tomography. Arch Gen Psychiatry. 2007;64(2):201–8.CrossRefGoogle ScholarPubMed
Parsey, R.V., Ogden, R.T., Miller, J.M., et al. Higher serotonin 1A binding in a second major depression cohort: modeling and reference region considerations. Biol Psychiatry. 2010;68(2):170–8.CrossRefGoogle Scholar
Sachs, G.S., Nierenberg, A.A., Calabrese, J.R., et al. Effectiveness of adjunctive antidepressant treatment for bipolar depression. N Engl J Med. 2007;356(17):1711–22.CrossRefGoogle ScholarPubMed
Sher, L., Oquendo, M.A., Li, S., et al. Prolactin response to fenfluramine administration in patients with unipolar and bipolar depression and healthy controls. Psychoneuroendocrinol. 2003;28(4):559–73.CrossRefGoogle ScholarPubMed
Sher, L., Carballo, J.J., Grunebaum, M.F., et al. A prospective study of the association of cerebrospinal fluid monoamine metabolite levels with lethality of suicide attempts in patients with bipolar disorder. Bipolar Disord. 2006;8(5):543–50.CrossRefGoogle ScholarPubMed
Shiah, I.S., Yatham, L.N. Serotonin in mania and in the mechanism of action of mood stabilizers: a review of clinical studies. Bipolar Disord. 2000;2(2):7792.CrossRefGoogle ScholarPubMed
Sidor, M.M., MacQueen, G.M. An update on antidepressant use in bipolar depression. Curr Psychiatry Rep. 2012;14(6):696704.CrossRefGoogle ScholarPubMed
Sobczak, S., Honig, A., van Duinen, M.A., et al. Serotonergic dysregulation in bipolar disorders: A literature review of serotonergic challenge studies. Bipolar Disord. 2002;4(6):347–56.CrossRefGoogle ScholarPubMed
Sullivan, G.M., Ogden, R.T., Oquendo, M.A., et al. Positron emission tomography quantification of serotonin-1A receptor binding in medication-free bipolar depression. Biol Psychiatry. 2009;66(3):223–30.CrossRefGoogle ScholarPubMed
Sullivan, G.M., Oquendo, M.A., Milak, M., et al. Positron emission tomography quantification of serotonin 1A receptor binding in suicide attempters with major depressive disorder. JAMA Psychiatry. 2015;72(2):169–78.CrossRefGoogle ScholarPubMed
Sun, Y., Zhang, L., Johnston, N.L., et al. Serial analysis of gene expression in the frontal cortex of patients with bipolar disorder. Br J Psychiatry Suppl. 2001;41:s137–41.Google ScholarPubMed
Thakore, J.H., O’Keane, V., Dinan, T.G. d-fenfluramine-induced prolactin responses in mania: evidence for serotonergic subsensitivity. Am J Psychiatry. 1996;153(11):1460–3.Google ScholarPubMed
Tohen, M., Vieta, E., Calabrese, J., et al. Efficacy of olanzapine and olanzapine-fluoxetine combination in the treatment of bipolar I depression. Arch Gen Psychiatry. 2003;60(11):1079–88.CrossRefGoogle ScholarPubMed
Tondo, L., Vazquez, G., Baldessarini, R.J. Mania associated with antidepressant treatment: comprehensive meta-analytic review. Acta Psychiatr Scand. 2010;121(6):404–14.CrossRefGoogle ScholarPubMed
Voigt, J.P., Fink, H. Serotonin controlling feeding and satiety. Behav Brain Res. 2015;277C:1431.CrossRefGoogle Scholar
Yatham, L.N., Liddle, P.F.,Lam, R.W., et al. A positron emission tomography study of the effects of treatment with valproate on brain 5-HT2A receptors in acute mania. Bipolar Disord. 2005;7(Suppl 5):5357.CrossRefGoogle ScholarPubMed
Young, L.T., Warsh, J.J., Kish, S.J., et al. Reduced brain 5-HT and elevated NE turnover and metabolites in bipolar affective disorder. Biol Psychiatry. 1994;35(2):121–7.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×