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  • Online publication date: May 2013

7 - Tactile system and nociception

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Barr, G.A., Gao, P., Wang, S., Cheng, J., Qin, J., Sibille, E.L., et al. (2005) Microarray analysis of gene expression following the formalin test in the infant rat. Pain 117: 6–18.
Basbaum, A.I. and Fields, H.L. (1984) Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annu Rev Neurosci 7: 309–338.
Belknap, J.K., Lamé, M., and Danielson, P.W. (1990) Inbred strain differences in morphine-induced analgesia with the hot plate assay: a reassessment. Behav Genet 20: 333–338.
Belknap, J.K., Mogil, J.S., Helms, M.L., Richards, S.P., O’Toole, L.A., Bergeson, S.E., et al. (1995) Localization to chromosome 10 of a locus influencing morphine analgesia in crosses derived from C57BL/6 and DBA/2 mouse strains. Life Sci 57: PL117–124.
Bergeson, S.E., Helms, M.L., O’Toole, L.A., Jarvis, M.W., Hain, H.S., Mogil, J.S., et al. (2001) Quantitative trait loci influencing morphine antinociception in four mapping populations. Mamm Genome 12: 546–553.
Bon, K., Lichtensteiger, C.A., Wilson, S.G., and Mogil, J.S. (2003) Characterization of cyclophosphamide cystitis, a model of visceral and referred pain in the mouse: species and strain differences. J Urol 170: 1008–1012.
Caterina, M.J., Leffler, A., Malmberg, A.B., Martin, W.J., Trafton, J., Petersen-Zeitz, K.R., et al. (2000) Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288: 306–313.
Chesler, E.J., Ritchie, J., Kokayeff, A., Lariviere, W.R., Wilson, S.G., and Mogil, J.S. (2003) Genotype-dependence of gabapentin and pregabalin sensitivity: the pharmacogenetic mediation of analgesia is specific to the type of pain being inhibited. Pain 106: 325–335.
Costigan, M., Befort, K., Karchewski, L., Griffin, R.S., D’Urso, D., Allchorne, A., et al. (2002) Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury. BMC Neurosci 3: 16.
Davis, J.B., Gray, J., Gunthorpe, M.J., Hatcher, J.P., Davey, P.T., Overend, P., et al. (2000) Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature 405: 183–187.
Devor, M., Gilad, A., Arbilly, M., Yakir, B., Raber, P., Pisante, A., et al. (2005) pain1: A neuropathic pain QTL on mouse chromosome 15 in a C3HxC58 backcross. Pain 116: 289–293.
Devor, M. and Raber, P. (1990) Heritability of symptoms in an experimental model of neuropathic pain. Pain 42: 51–67.
Dubuisson, D. and Dennis, S.G. (1977) The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats. Pain 4: 161–174.
Elmer, G.I., Pieper, J.O., Negus, S.S., and Woods, J.H. (1998) Genetic variance in nociception and its relationship to the potency of morphine-induced analgesia in thermal and chemical tests. Pain 75(1): 129–140.
Falconer, D.S. and Mackay, T.F.C. (1996) Introduction to Quantitative Genetics, 4th edn. Longman, Essex, UK.
Fortin, A., Diez, E., Rochefort, D., Laroche, L., Malo, D., Rouleau, G.A., et al. (2001) Recombinant congenic strains derived from A/J and C57BL/6J: a tool for genetic dissection of complex traits. Genomics 74: 21–35.
Furuse, T., Miura, Y., Yagasaki, K., Shiroishi, T., and Koide, T. (2003) Identification of QTLs for differential capsaicin sensitivity between mouse strains KJR and C57BL/6. Pain 105: 169–175.
Green, A.D., Young, K.K., Lehto, S.G., Smith, S.B., and Mogil, J.S. (2006) Influence of genotype, dose and sex on pruritogen-induced scratching behavior in the mouse. Pain 124(1–2): 50–58.
Grupe, A., Germer, S., Usuka, J., Aud, D., Belknap, J.K., Klein, R.F., et al. (2001) In silico mapping of complex disease-related traits in mice. Science 292: 1915–1918.
Hain, H.S., Belknap, J.K., and Mogil, J.S. (1999) Pharmacogenetic evidence for the involvement of 5-hydroxytryptamine (serotonin)-1B receptors in the mediation of morphine antinociceptive sensitivity. J Pharmacol Exp Ther 291(2): 444–449.
Hargreaves, K., Dubner, R., Brown, F., Flores, C., and Joris, J. (1988) A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32: 77–88.
Ikeda, K., Kobayashi, T., Kumanishi, T., Niki, H., and Yano, R. (2000) Involvement of G-protein-activated inwardly rectifying K+ (GIRK) channels in opioid-induced analgesia. Neurosci Res 38: 113–116.
Inagaki, N., Nagao, M., Igeta, K., Kawasaki, H., Kim, J.F., and Nagai, H. (2001) Scratching behavior in various strains of mice. Skin Pharmacol Appl Skin Physiol 14: 87–96.
Kest, B., Wilson, S.G., and Mogil, J.S. (1999) Sex differences in supraspinal morphine analgesia are dependent on genotype. J Pharmacol Exp Ther 289(3): 1370–1375.
Kim, D.-S., Lee, S.-J., Park, S.-Y., Yoo, H.-J., Kim, S.-H., Kim, K.-J., et al. (2001) Differentially expressed genes in rat dorsal root ganglia following peripheral nerve injury. Neuroreport 12(15): 3401–3405.
Kim, H., Neubert, J.K., Rowan, J.S., Brahim, J.S., Iadarola, M.J., and Dionne, R.A. (2004) Comparison of experimental and acute clinical pain responses in humans as pain phenotypes J Pain 5: 377–384.
Kuraishi, Y., Nagasawa, T., Hayashi, K., and Satoh, M. (1995) Scratching behavior induced by pruritogenic but not algesiogenic agents in mice. Eur J Pharmacol 275: 229–233.
Kuraishi, Y., Yamaguchi, T., and Miyamoto, T. (2000) Itch-scratch responses induced by opioids through central mu opioid receptors in mice. J Biomed Sci 7: 248–252.
LaCroix-Fralish, M.L., Mo, G., Smith, S.B., Sotocinal, S.B., Ritchie, J., Austin, J.-S., et al. (2009) The β3 subunit of the Na+,K+-ATPase affects pain sensitivity. Pain 144: 294–302.
LaCroix-Fralish, M.L., Mogil, J.S., Weinstein, J.N., Rutkowski, M.D., and DeLeo, J.A. (2005) The magnitude of mechanical allodynia in a rodent model of lumbar radiculopathy is dependent on strain and sex. Spine 30: 1821–1827.
Lariviere, W.R., Chesler, E.J., and Mogil, J.S. (2001) Transgenic studies of pain and analgesia: mutation or background phenotype? J Pharmacol Exp Ther 297: 467–473.
Lariviere, W.R., Wilson, S.G., Laughlin, T.M., Kokayeff, A., West, E.E., Adhikari, S.M., et al. (2002) Heritability of nociception. III. Genetic relationships among commonly used assays of nociception and hypersensitivity. Pain 97: 75–86.
Libman, E. (1934) Observations on individual sensitiveness to pain. J Am Med Assoc 102: 335–341.
Liem, E.B., Joiner, T.V., Tsueda, K., and Sessler, D.I. (2005) Increased sensitivity to thermal pain and reduced subcutaneous lidocaine efficacy in redheads. Anesthesiology 102: 509–514.
MacGregor, A.J. (2004) The heritability of pain in humans. In Mogil, J.S. (ed.), The Genetics of Pain, Progress in Pain Research and Management, Vol. 28. IASP Press, Seattle, WA, USA, pp. 151–170.
MacGregor, A.J., Griffiths, G.O., Baker, J., and Spector, T.D. (1997) Determinants of pressure pain threshold in adult twins: evidence that shared environmental influences predominate. Pain 73: 253–257.
Maekawa, T., Nojima, H., and Kuraishi, Y. (2000) Itch-associated responses of afferent nerve innervating the murine skin: different effects of histamine and serotonin in ICR and ddY mice. Jpn J Pharmacol 84: 462–466.
Matthes, H.W.D., Maldonado, R., Simonin, F., Valverde, O., Slowe, S., Kitchen, I., et al. (1996) Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene. Nature 383: 819–823.
Melzack, R. (1975) The McGill Pain Questionnaire: major properties and scoring methods. Pain 1: 277–299.
Mogil, J.S. (1999) The genetic mediation of individual differences in sensitivity to pain and its inhibition. Proc Natl Acad Sci USA 96: 7744–7751.
Mogil, J.S. (2003) Interaction between sex and genotype in the mediation of pain and pain inhibition. Sem Pain Med 1: 197–205.
Mogil, J.S. (2009) Animal models of pain: progress and challenges. Nat Rev Neurosci 10: 283–294.
Mogil, J.S., and Adhikari, S.M. (1999) Hot and cold nociception are genetically correlated. J Neurosci 19: 21–25.
Mogil, J.S., and Belknap, J.K. (1997) Sex and genotype determine the selective activation of neurochemically distinct mechanisms of swim stress-induced analgesia. Pharmacol Biochem Behav 56: 61–66.
Mogil, J.S., Chesler, E.J., Wilson, S.G., Juraska, J.M., and Sternberg, W.F. (2000b) Sex differences in thermal nociception and morphine antinociception in rodents depend on genotype. Neurosci Biobehav Rev 24: 375–389.
Mogil, J.S., Flodman, P., Spence, M.A., Sternberg, W.F., Kest, B., Sadowski, B., et al. (1995a) Oligogenic determination of morphine analgesic magnitude: a genetic analysis of selectively bred mouse lines. Behav Genet 25: 397–406.
Mogil, J.S., and Grisel, J.E. (1998) Transgenic studies of pain. Pain 77: 107–128.
Mogil, J.S., Kest, B., Sadowski, B., and Belknap, J.K. (1996b) Differential genetic mediation of sensitivity to morphine in genetic models of opiate antinociception: influence of nociceptive assay. J Pharmacol Exp Ther 276: 532–544.
Mogil, J.S., Lichtensteiger, C.A., and Wilson, S.G. (1998) The effect of genotype on sensitivity to inflammatory nociception: characterization of resistant (A/J) and sensitive (C57BL/6) inbred mouse strains. Pain 76: 115–125.
Mogil, J.S., Marek, P., Flodman, P., Spence, M.A., Sternberg, W.F., Kest, B., et al. (1995b) One or two genetic loci mediate high opiate analgesia in selectively bred mice. Pain 60: 125–135.
Mogil, J.S., Meirmeister, F., Seifert, F., Strasburg, K., Zimmermann, K., Reinold, H., et al. (2005b) Variable sensitivity to noxious heat is mediated by differential expression of the CGRP gene. Proc Natl Acad Sci USA 102: 12938–12943.
Mogil, J.S., Richards, S.P., O’Toole, L.A., Helms, M.L., Mitchell, S.R., and Belknap, J.K. (1997a) Genetic sensitivity to hot-plate nociception in DBA/2J and C57BL/6J inbred mouse strains: possible sex-specific mediation by δ2-opioid receptors. Pain 70: 267–277.
Mogil, J.S., Richards, S.P., O’Toole, L.A., Helms, M.L., Mitchell, S.R., Kest, B., et al. (1997b) Identification of a sex-specific quantitative trait locus mediating nonopioid stress-induced analgesia in female mice. J Neurosci 17: 7995–8002.
Mogil, J.S., Ritchie, J., Smith, S.B., Strasburg, K., Kaplan, L., Wallace, M.R., et al. (2005c) Melanocortin-1 receptor gene variants affect pain and µ-opioid analgesia in mice and humans. J Med Genet 42: 583–587.
Mogil, J.S., Smith, S.B., O’Reilly, M.K., and Plourde, G. (2005a) Influence of nociception and stress-induced antinociception on genetic variation in isoflurane anesthetic potency among mouse strains. Anesthesiology 103(4): 751–758.
Mogil, J.S., Sternberg, W.F., Kest, B., Marek, P., and Liebeskind, J.C. (1993) Sex differences in the antagonism of swim stress-induced analgesia: effects of gonadectomy and estrogen replacement. Pain 53: 17–25.
Mogil, J.S., Sternberg, W.F., Marek, P., Sadowski, B., Belknap, J.K., and Liebeskind, J.C. (1996a) The genetics of pain and pain inhibition. Proc Natl Acad Sci USA 93: 3048–3055.
Mogil, J.S., Wilson, S.G., Bon, K., Lee, S.E., Chung, K., Raber, P., et al. (1999a) Heritability of nociception. I. Responses of eleven inbred mouse strains on twelve measures of nociception. Pain 80: 67–82.
Mogil, J.S., Wilson, S.G., Bon, K., Lee, S.E., Chung, K., Raber, P., et al. (1999b) Heritability of nociception. II. “Types” of nociception revealed by genetic correlation analysis. Pain 80: 83–93.
Mogil, J.S., Wilson, S.G., Chesler, E.J., Rankin, A.L., Nemmani, K.V.S., Lariviere, W.R., et al. (2003) The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans. Proc Natl Acad Sci USA 100: 4867–4872.
Mogil, J.S., Yu, L., and Basbaum, A.I. (2000a) Pain genes? Natural variation and transgenic mutants. Annu Rev Neurosci 23: 777–811.
Nielsen, C.S., Stubhaug, A., Price, D.D., Vassend, O., Czajkowski N, and Harris, J.R. (2008) Individual differences in pain sensitivity: genetic and environmental contributions. Pain 2008 136: 21–29.
Nojima, H. and Carstens, E. (2003) Quantitative assessment of directed hind limb scratching behavior as a rodent itch model. J Neurosci Meth 126: 137–143.
Norbury, T.A., MacGregor, A.J., Urwin, J., Spector, T.D., and McMahon, S.B. (2007) Heritability of responses to painful stimuli in women: a classical twin study. Brain 130: 3041–3049.
Paigen, K. and Eppig, J.T. (2000) A Mouse Phenome Project. Mamm Genome 11: 715–717.
Panocka, I. and Marek, P. (1986) Inheritance of stress-induced analgesia in mice. Ann N Y Acad Sci 467: 441–443.
Rabert, D., Xiao, Y., Yiangou, Y., Kreder, D., Sangameswaran, L., Segal, M.R., et al. (2004) Plasticity of gene expression in injured human dorsal root ganglia revealed by GeneChip oligonucleotide microarrays. J Clin Neurosci 11: 289–299.
Rady, J.J., Elmer, G.I., and Fujimoto, J.M. (1999) Opioid receptor selectivity of heroin given intracerebroventricularly differs in six strains of inbred mice. J Pharmacol Exp Ther 288: 438–445.
Seltzer, Z., Wu, T., Max, M.B., and Diehl, S.R. (2001) Mapping a gene for neuropathic pain-related behavior following peripheral neurectomy in the mouse. Pain 93: 101–106.
Smith, S.B., Crager, S.E., and Mogil, J.S. (2004) Paclitaxel-induced neuropathic hypersensitivity in mice: responses in 10 inbred mouse strains. Life Sci 74: 2593–2604.
Smith, S.B., Marker, C.L., Perry, C., Liao, G., Sotocinal, S.G., Austin, J.-S., et al. (2008) Quantitative trait locus and computational mapping identifies Kcnj9 (GIRK3) as a candidate gene affecting analgesia from multiple drug classes. Pharmacogenet Genom 18: 231–241.
Sowunmi, A., Walker, O., and Salako, L.A. (1989) Pruritus and antimalarial drugs in Africans. Lancet 2: 213.
Sun, H., Xu, J., Della Penna, K.B., Benz, R.J., Kinose, F., Holder, D.J., et al. (2002) Dorsal horn-enriched genes identified by DNA microarray, in situ hybridization and immunohistochemistry. BMC Neurosci 3: 11.
Takagi, H., Inukai, T., and Nakama, M. (1966) A modification of Haffner's method for testing analgesics. Jpn J Pharmacol 16: 287–294.
Vaccarino, A.L., Tasker, R.A.R., and Melzack, R. (1988) Systemic administration of naloxone produces analgesia in BALB/c mice in the formalin pain test. Neurosci Lett 84: 103–107.
Valder, C.R., Liu, J.-J., Song, Y.-H., and Luo, Z.D. (2003) Coupling gene chip analyses and rat genetic variances in identifying potential target genes that may contribute to neuropathic allodynia development. J Neurochem 87: 560–573.
Valverde, P., Healy, E., Jackson, I., Rees, J.L., and Thody, A.J. (1995) Variants of the melanocyte-stimulating hormone receptor gene are associated with red hair and fair skin in humans. Nat Genet 11: 328–330.
van Rossum, D., Hanisch, U.-K., and Quirion, R. (1997) Neuroanatomical localization, pharmacological characterization and functions of CGRP, related peptides and their receptors. Neurosci Biobehav Rev 21: 649–678.
Wang, H., Sun, H., Della Penna, K.B., Benz, R.J., Xu, J., Gerhold, D.L., et al. (2002) Chronic neuropathic pain is accompanied by global changes in gene expression and shares pathobiology with neurodegenerative diseases. Neuroscience 114: 529–546.
Wilson, S.G., Chesler, E.J., Hain, H.S., Rankin, A.L., Schwarz, J.Z., Call, S.B., et al. (2002) Identification of quantitative trait loci for chemical/inflammatory nociception in mice. Pain 96: 385–391.
Wilson, S.G. and Mogil, J.S. (2001) Measuring pain in the (knockout) mouse: big challenges in a small mammal. Behav Brain Res 125: 65–73.
Wilson, S.G., Smith, S.B., Chesler, E.J., Melton, K.A., Haas, J.J., Mitton, B.A., et al. (2003) The heritability of antinociception: common pharmacogenetic mediation of five neurochemically distinct analgesics. J Pharmacol Exp Ther 304: 547–559.
Xiao, H.-S., Huang, Q.-H., Zhang, F.-X., Bao, L., Lu, Y.-J., Guo, C., et al. (2002) Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain. Proc Natl Acad Sci USA 99: 8360–8365.
Xu, X.-J. and Wiesenfeld-Hallin, Z. (2004) Individual differences in pain: rat models. In Mogil, J.S. (ed.), The Genetics of Pain, Progress in Pain Research and Management, Vol. 28, IASP Press, Seattle, WA, USA, pp. 107–121.