Book contents
- Atlas of Pediatric Hematopathology
- Atlas of Pediatric Hematopathology
- Copyright page
- Contents
- Contributors
- Section I Peripheral Blood
- Chapter 1 Peripheral Blood Smear Review
- Chapter 2 Red Blood Cell Disorders
- Chapter 3 Neutrophil and Platelet Disorders
- Chapter 4 Infectious Diseases and Nutritional Deficiencies
- Section II Normal and Non-neoplastic Hematolymphoid Diseases
- Section III Mature Lymphoid Neoplasm
- Section IV Precursor Hematopoietic Neoplasms and Related Neoplasms
- Section V Histiocytic Neoplasm and Miscellaneous Bone Marrow Diseases
- Index
- References
Chapter 3 - Neutrophil and Platelet Disorders
from Section I - Peripheral Blood
Published online by Cambridge University Press: 25 November 2023
- Atlas of Pediatric Hematopathology
- Atlas of Pediatric Hematopathology
- Copyright page
- Contents
- Contributors
- Section I Peripheral Blood
- Chapter 1 Peripheral Blood Smear Review
- Chapter 2 Red Blood Cell Disorders
- Chapter 3 Neutrophil and Platelet Disorders
- Chapter 4 Infectious Diseases and Nutritional Deficiencies
- Section II Normal and Non-neoplastic Hematolymphoid Diseases
- Section III Mature Lymphoid Neoplasm
- Section IV Precursor Hematopoietic Neoplasms and Related Neoplasms
- Section V Histiocytic Neoplasm and Miscellaneous Bone Marrow Diseases
- Index
- References
Summary
Neutrophils are known as the first responders at the sites of infection and injury, but their role in thrombosis is also being recognized. Platelets are known to be an important component in maintaining hemostasis and controlling the bleeding at the site of trauma, as well as in immune modulation [1]. Although some conditions are classified as neutrophilic disorders, they also show clinical manifestations associated with platelet dysfunction, or vice versa. For example, Chediak-Higachi disease is commonly known as neutrophil function disorder; however, it has bleeding history due to abnormal lysosome-like structures inside platelets. Similarly, MYH9-related disorders and Hemansky-Pudlak syndrome are associated with macrothrombocytopenia and storage pool defect but also characterized by neutropenia with recurrent infection and impaired cytotoxic activity.
- Type
- Chapter
- Information
- Atlas of Pediatric Hematopathology , pp. 17 - 25Publisher: Cambridge University PressPrint publication year: 2023