Skip to main content Accessibility help
×
Home
Hostname: page-component-7f7b94f6bd-dwjtz Total loading time: 0.736 Render date: 2022-06-30T23:41:48.396Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "useRatesEcommerce": false, "useNewApi": true } hasContentIssue true

4 - Long-term potentiation and long-term depression

from Section A1 - Cellular and molecular mechanisms of neural plasticity

Published online by Cambridge University Press:  05 March 2012

Zafir I. Bashir
Affiliation:
Department of Anatomy, MRC Centre for Synaptic Plasticity, University of Bristol, Bristol, UK
Peter V. Massey
Affiliation:
Department of Anatomy, MRC Centre for Synaptic Plasticity, University of Bristol, Bristol, UK
Michael Selzer
Affiliation:
University of Pennsylvania
Stephanie Clarke
Affiliation:
Université de Lausanne, Switzerland
Leonardo Cohen
Affiliation:
National Institute of Mental Health, Bethesda, Maryland
Pamela Duncan
Affiliation:
University of Florida
Fred Gage
Affiliation:
Salk Institute for Biological Studies, San Diego
Get access

Summary

This chapter concentrates on the basic mechanisms that are thought to underlie induction and expression of long-term plasticity (LTP). LTP has been demonstrated at all of the major synapses in the hippocampus. Activity-dependent LTP is a commonly observed feature of the neocortex and does not differ from the hippocampus in its induction or expression mechanisms. The induction and/or the magnitude of LTP and long-term depression (LTD) can be affected by prior activity that in itself does not produce observable changes in synaptic efficacy. Thus there is some plastic change of a different, or meta, form that influences traditional synaptic plasticity. N-methyl-D-aspartate receptors (NMDAR)-mediated synaptic transmission can undergo potentiation and depression, and given the critical role for NMDARs in LTP and LTD induction it is apparent that any change in NMDAR synaptic transmission brought about by a priming stimulus could have dramatic consequences for induction of LTP and LTD.
Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2006

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)
1
Cited by

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×