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Chapter 7 - Assisted Reproduction

Published online by Cambridge University Press:  25 February 2021

Siladitya Bhattacharya
Affiliation:
University of Aberdeen
Mark Hamilton
Affiliation:
University of Aberdeen
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Summary

Assisted reproduction technology (ART) encompasses fertility treatments which require manipulation of oocyte, sperm or both in vitro. This chapter aims to provide an overview of ART, including indications for treatment as well as the procedures involved. This will also include complications of ART as well as the evidence assessing the perinatal outcomes of children resulting from ART.

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Chapter
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Publisher: Cambridge University Press
Print publication year: 2021

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References

NICE guideline: Fertility problems: assessment and treatment. Clinical guideline [CG156]. February 2013.Google Scholar
Bhattacharya, S, Harrild, K, Mollison, J, Wordsworth, S, Tay, C, Harrold, A, et al. Clomifene citrate or unstimulated intrauterine insemination compared with expectant management for unexplained infertility: pragmatic randomised controlled trial. BMJ. 2008;337:a716.CrossRefGoogle ScholarPubMed
HFEA publication on fertility treatment 2014–2016: Trends and figures.Google Scholar
Farquhar, CM, Liu, E, Armstrong, S, Arroll, N, Lensen, S, Brown, J. Intrauterine insemination with ovarian stimulation versus expectant management for unexplained infertility (TUI): a pragmatic, open-label, randomised, controlled, two-centre trial. Lancet. 2018;391(10119):441–50.Google ScholarPubMed
Al‐Inany, HG, Youssef, MA, Ayeleke, RO, Brown, J, Lam, WS, Broekmans, FJ. Gonadotrophin‐releasing hormone antagonists for assisted reproductive technology. Cochrane Database Syst. Rev. 2016; 4:CD001750.CrossRefGoogle ScholarPubMed
Lensen, SF, Wilkinson, J, Leijdekkers, JA, La Marca, A, Mol, BWJ, Marjoribanks, J, Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro fertilisation plus intracytoplasmic sperm injection (IVF/ICSI). Cochrane Database Syst Rev. 2018;2:CD012693. DOI: 10.1002/14651858.CD012693.pub2.Google Scholar
Chen, ZJ, Shi, Y, Sun, Y, Zhang, B, Liang, X, Cao, Y, et al. Fresh versus frozen embryos for infertility in the Polycystic Ovary Syndrome. N Engl J Med. 2016 Aug 11;375(6):523–33.CrossRefGoogle ScholarPubMed
Roque, M, Haahr, T, Geber, S, Esteves, SC, Humaidan, P. Fresh versus elective frozen embryo transfer in IVF/ICSI cycles: a systematic review and meta-analysis of reproductive outcomes. Hum Reprod Update. 2019;25(1):214. DOI: 10.1093/humupd/dmy033.CrossRefGoogle ScholarPubMed
RCOG. Green-top Guideline No. 5: The Management of Ovarian Hyperstimulation Syndrome. February 2016.Google Scholar

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