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Preface

Published online by Cambridge University Press:  20 August 2009

Shirley Hodgson
Affiliation:
St George's Hospital Medical School, London
William Foulkes
Affiliation:
McGill University, Montréal
Charis Eng
Affiliation:
Cleveland Clinic Foundation
Eamonn Maher
Affiliation:
University of Birmingham
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Summary

There continue to be rapid developments in our understanding of inherited cancer susceptibility and the importance of this for the translation of this knowledge into clinical practice. There appear to be differences in the pathways of carcinogenesis in individuals with differing inherited cancer susceptibility syndromes, which can lead to improved strategies for surveillance and management. Gene expression studies have revolutionised our understanding of many aspects of this. An example is that carriers of germline mutations in BRCA1 have breast cancers which have particular pathological characteristics which in turn can indicate an increased chance that a woman carries a BRCA1 mutation, and the fact that specific types of DNA damage repair is deficient in BRCA1 mutation carriers has led to the suggestion that cancers in such women may be more sensitive to treatment with cisplatin and PARP inhibitors. The discovery of MYH (MUTYH)-associated polyposis has highlighted the presence of autosomal recessive inheritance patterns for conditions originally thought to be predominantly autosomal dominant conditions.

The development of sensitive counselling practices for predictive testing for cancer predisposing conditions, taking into account the psychosocial, insurance and ethical issues has been continued as part of ongoing collaboration between different genetic centres and professionals. The inclusion of nurses and genetic counsellors in the development of cancer genetics services is essential, and training is taking this into account.

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Chapter
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Publisher: Cambridge University Press
Print publication year: 2006

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  • Preface
  • Shirley Hodgson, St George's Hospital Medical School, London, William Foulkes, McGill University, Montréal, Charis Eng, Cleveland Clinic Foundation, Eamonn Maher, University of Birmingham
  • Book: A Practical Guide to Human Cancer Genetics
  • Online publication: 20 August 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511545832.002
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  • Preface
  • Shirley Hodgson, St George's Hospital Medical School, London, William Foulkes, McGill University, Montréal, Charis Eng, Cleveland Clinic Foundation, Eamonn Maher, University of Birmingham
  • Book: A Practical Guide to Human Cancer Genetics
  • Online publication: 20 August 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511545832.002
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Preface
  • Shirley Hodgson, St George's Hospital Medical School, London, William Foulkes, McGill University, Montréal, Charis Eng, Cleveland Clinic Foundation, Eamonn Maher, University of Birmingham
  • Book: A Practical Guide to Human Cancer Genetics
  • Online publication: 20 August 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511545832.002
Available formats
×