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17 - Management of cancer of the anus

Published online by Cambridge University Press:  05 November 2015

Richard Adams
Affiliation:
Velindre Cancer Centre, Velindre Hospital, Cardiff, UK
Paul Shaw
Affiliation:
Cardiff University, Cardiff, UK
Louise Hanna
Affiliation:
Velindre Cancer Centre, Velindre Hospital, Cardiff
Tom Crosby
Affiliation:
Velindre Cancer Centre, Velindre Hospital, Cardiff
Fergus Macbeth
Affiliation:
Velindre Cancer Centre, Velindre Hospital, Cardiff
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Publisher: Cambridge University Press
Print publication year: 2015

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References

Anal Cancer Trial Working Party. (1996). Epidermoid anal cancer: results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5-fluorouracil and mitomycin. Lancet, 348, 1049–1054.
Andreyev, H. J., Benton, B., Lalji, A., et al. (2013). Algorithm-based management of patients with gastrointestinal symptoms in patients after pelvic radiation treatment (ORBIT): a randomised controlled trial. Lancet, 382, 2084–2092.CrossRefGoogle ScholarPubMed
Bartelink, H., Roelofsen, F., Eschwege, F., et al. (1997). Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups. J. Clin. Oncol., 15, 2040–2049.Google ScholarPubMed
Charnley, N., Choudhury, A., Chesser, P., et al. (2005). Effective treatment of anal cancer in the elderly with low-dose chemoradiotherapy. Br. J. Cancer, 92, 1221–1225.CrossRefGoogle ScholarPubMed
Cummings, B., Keane, T., Thomas, G., et al. (1984). Results and toxicity of the treatment of anal canal carcinoma by radiation therapy or radiation therapy and chemotherapy. Cancer, 54, 2062–2068.3.0.CO;2-T>CrossRefGoogle ScholarPubMed
Daling, J. R., Weiss, N. S., Klopfenstein, L. L., et al. (1982). Correlates of homosexual behavior and the incidence of anal cancer. J. Am. Med. Assoc., 247, 1988–1990.CrossRefGoogle ScholarPubMed
Daling, J. R., Weiss, N. S., Hislop, T. G., et al. (1987). Sexual practices, sexually transmitted diseases and the incidence of anal cancer. N. Engl. J. Med., 317, 973–977.CrossRefGoogle ScholarPubMed
Flam, M., John, M., Pajak, T. F., et al. (1996). Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of a phase III randomized intergroup study. J. Clin. Oncol., 14, 2527–2539.CrossRefGoogle ScholarPubMed
Fuccio, L., Guido, A. and Andreyev, H. J. (2012). Management of intestinal complications in patients with pelvic radiation disease. Clin. Gastroenterol. Hepatol., 10, 1326–1334.CrossRefGoogle ScholarPubMed
Gilbert, D. C., Williams, A., Allan, K., et al. (2013). p16INK4A, p53, EGFR expression and KRAS mutation status in squamous cell cancers of the anus: correlation with outcomes following chemo-radiotherapy. Radiother. Oncol., 109, 146–151.CrossRefGoogle ScholarPubMed
Glynne-Jones, R., Meadows, H., Wan, S., et al. (2008). EXTRA – a multicenter phase II study of chemoradiation using a 5 day per week oral regimen of capecitabine and intravenous mitomycin C in anal cancer. Int. J. Radiat. Oncol. Biol. Phys., 72, 119–126.CrossRefGoogle Scholar
Glynne-Jones, R., Sebag-Montefiore, D., Adams, R., et al. (2011). ‘Mind the gap’ – the impact of variations in the duration of the treatment gap and overall treatment time in the first UK Anal Cancer Trial (ACT I). Int. J. Radiat. Oncol. Biol. Phys., 81, 1488–1494.CrossRefGoogle Scholar
Gunderson, L. L.Winter, K. A., Ajani, J. A., et al. (2012). Long-term update of US GI Intergroup RTOG 98-11 phase III trial for anal carcinoma: survival, relapse, colostomy failure with concurrent chemoradiation involving fluorouracil/mitomycin versus fluorouracil/cisplatin. J. Clin. Oncol., 30, 4344–4351.CrossRefGoogle ScholarPubMed
Hu, K., Minsky, B. D., Cohen, A. M., et al. (1999). 30 Gy may be an adequate dose in patients with anal cancer treated with excisional biopsy followed by combined modality therapy. J. Surg. Oncol., 70, 71–77.3.0.CO;2-Y>CrossRefGoogle ScholarPubMed
James, R. D., Glynne-Jones, R., Meadows, H. M., et al. (2013). Mitomycin or cisplatin chemoradiation with or without maintenance chemotherapy for treatment of squamous-cell carcinoma of the anus (ACT II): a randomised, phase 3, open-label, 2 x 2 factorial trial. Lancet Oncol., 14, 516–524.CrossRefGoogle ScholarPubMed
Matthews, J. H., Burmeister, B. H., Borg, M., et al. (2011). T1–2 anal carcinoma requires elective inguinal radiation treatment – the results of Trans Tasman Radiation Oncology Group study TROG 99.02. Radiat. Oncol., 98, 93–98.Google ScholarPubMed
Ng, M., Leong, T., Chander, S., et al. (2012). Australasian Gastrointestinal Trials Group (AGITG) contouring atlas and planning guidelines for intensity-modulated radiotherapy in anal cancer. Int. J. Radiat. Oncol. Biol. Phys., 83, 1455–1462.CrossRefGoogle ScholarPubMed
NICE. (2004). Guidance on Cancer Services. Improving Outcomes in Colorectal Cancers. Manual Update. London: National Institute for Health and Care Excellence.
Nigro, N. D., Vaitkevicius, V. K. and Considine, B., Jr. (1974). Combined therapy for cancer of the anal canal: a preliminary report. Dis. Colon Rectum, 17, 354–356.CrossRefGoogle ScholarPubMed
Nigro, N. D., Seydel, H. G., Considine, B., et al. (1983). Combined preoperative radiation and chemotherapy for squamous cell carcinoma of the anal canal. Cancer, 51, 1826–1829.3.0.CO;2-L>CrossRefGoogle ScholarPubMed
Peiffert, D., Tournier-Rangeard, L., Gérard, J. P., et al. (2012). Induction chemotherapy and dose intensification of the radiation boost in locally advanced anal canal carcinoma: final analysis of the randomized UNICANCER ACCORD 03 trial. J. Clin. Oncol., 30, 1941–1948.CrossRefGoogle ScholarPubMed
Renehan, A. G., Saunders, M. P., Schofield, P. F., et al. (2005). Patterns of local disease failure and outcome after salvage surgery in patients with anal cancer. Br. J. Surg., 92, 605–614.CrossRefGoogle ScholarPubMed
Royal College of Radiologists. (2008). The Timely Delivery of Radical Radiotherapy: Standards and Guidelines for the Management of Unscheduled Treatment Interruptions, Third Edition, 2008.London: Royal College of Radiologists.
Saboo, S. S., Zukotynski, K., Shinagare, A. B., et al. (2013). Anal carcinoma: FDG PET/CT in staging, response evaluation, and follow-up. Abdom. Imaging, 38, 728–735.CrossRefGoogle ScholarPubMed
Tilston, P. (1997). Anal human papilloma virus and anal cancer. J. Clin. Pathol., 50, 625–634.CrossRefGoogle ScholarPubMed
UICC. (2009). TNM Classification of Malignant Tumours, ed. Sobin, L. H., Gospodarowicz, M and Wittekind, Ch., 7th edn. Chichester: Wiley-Blackwell, pp. 106–109.
Weber, D. C., Kurtz, J. M. and Allal, A. S. (2001). The impact of gap duration on local control in anal canal carcionma treated by split-course radiotherapy and concomitant chemotherapy. Int. J. Radiat. Oncol. Biol. Phys., 50, 675–680.CrossRefGoogle Scholar
Wiesendanger-Wittmer, E. M., Sijtsema, N. M., Muijs, C. T., et al. (2012). Systematic review of the role of a belly board device in radiotherapy delivery in patients with pelvic malignancies. Radiother. Oncol., 102, 325–334.CrossRefGoogle ScholarPubMed

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