The pragmatic partnership among West European nations that has emerged since 1945 exemplifies how “win-win” strategies can bring powerfully beneficial results over time. Yet the EU model cannot be straightforwardly applied at the global level, for five reasons. First, the cultural and political differences among the world’s nations are much greater than they are within Europe. Second, the obscene divide between “haves” and “have-nots” is much starker and more intractable at the global level than it is within Europe. Third, rapid globalization has caused a political backlash in many nations, bringing to power leaders who seek a defensive retrenchment behind national walls. Fourth, global institutions of cultural integration, such as UNESCO, remain relatively weak. And fifth, racist prejudice and nativist xenophobia are on the rise in many nations. Nevertheless, the historical precedent set by the EU demonstrates that national sovereignty can be incrementally dismantled, yielding new forms of institutionalized cooperation among formerly separate and mutually hostile peoples.