Skip to main content Accessibility help
×
Hostname: page-component-848d4c4894-xfwgj Total loading time: 0 Render date: 2024-06-19T08:58:57.509Z Has data issue: false hasContentIssue false

Chapter 40 - Intrahepatic Cholestasis of Pregnancy

from Section 7 - Hepato-Renal and Gastrointestinal Conditions in Pregnancy

Published online by Cambridge University Press:  23 February 2023

Amira El-Messidi
Affiliation:
McGill University, Montréal
Alan D. Cameron
Affiliation:
University of Glasgow
Get access

Summary

During your overnight call duty, a 37-year-old G2P1 with a spontaneous pregnancy presents to the obstetrics emergency assessment unit of your tertiary center at 32+3 weeks’ gestation with pruritis preventing her from sleep. She has no obstetric complaints; cardiotocography initiated upon the patient’s presentation shows a normal fetal heart tracing and uterine quiescence.

Type
Chapter
Information
OSCEs in Obstetrics and Maternal-Fetal Medicine
An Evidence-Based Approach
, pp. 521 - 530
Publisher: Cambridge University Press
Print publication year: 2023

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Suggested Readings

ACOG Committee Opinion No. 764: Medically indicated late-preterm and early-term deliveries. Obstet Gynecol. 2019 Feb;133(2):e151e155.CrossRefGoogle Scholar
Bicocca, MJ, Sperling, JD, Chauhan, SP. Intrahepatic cholestasis of pregnancy: Review of six national and regional guidelines. Eur J Obstet Gynecol Reprod Biol. 2018 Dec; 231:180187.CrossRefGoogle ScholarPubMed
Chappell, LC, Bell, JL, Smith, A, et al. Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): a randomised controlled trial. Lancet. 2019 Sep 7;394(10201):849860.CrossRefGoogle ScholarPubMed
Geenes, V, Chappell, LC, Seed, PT, et al. Association of severe intrahepatic cholestasis of pregnancy with adverse pregnancy outcomes: a prospective population-based case-control study. Hepatology. 2014 Apr;59(4):14821491.CrossRefGoogle ScholarPubMed
Ovadia, C, Seed, PT, Sklavounos, A, et al. Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses. Lancet. 2019 Mar 2;393(10174):899909. [Erratum in Lancet. 2019 Mar 16;393(10176):1100]Google Scholar
Royal College of Obstetricians and Gynaecologists. Obstetric cholestasis: Green-Top Guideline No. 43. London: Royal College of Obstetricians and Gynaecologists; 2011.Google Scholar
Walker, KF, Chappell, LC, Hague, WM, et al. Pharmacological interventions for treating intrahepatic cholestasis of pregnancy. Cochrane Database Syst Rev. 2020 Jul 27;7(7):CD000493.Google ScholarPubMed
Society for Maternal-Fetal Medicine (SMFM). Lee, RH, Greenberg, M, Metz, TD, et al. Society for Maternal-Fetal Medicine Consult Series No. 53: Intrahepatic cholestasis of pregnancy: Replaces Consult No. 13, April 2011. Am J Obstet Gynecol. 2021;224(2):B2B9.CrossRefGoogle Scholar
Tran, TT, Ahn, J, Reau, NS. American College of Gastroenterology (ACG) clinical guideline: liver disease and pregnancy. Am J Gastroenterol. 2016; 111(2):176194.CrossRefGoogle Scholar
Williamson, C, Geenes, V. Intrahepatic cholestasis of pregnancy. Obstet Gynecol. 2014 Jul;124(1):120133.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×