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Chapter 9 - Health of Children Born after Intracytoplasmic Sperm Injections (ICSI)

Published online by Cambridge University Press:  02 December 2021

Gianpiero D. Palermo
Cornell Institute of Reproductive Medicine, New York
Zsolt Peter Nagy
Reproductive Biology Associates, Atlanta, GA
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Intracytoplasmic sperm injection (ICSI) is currently the most commonly used assisted reproductive technology (ART) for management of male-factor infertility. Being a relatively new and invasive procedure, limited data are available with regards to the perinatal, neonatal and long-term health of children born as a result of this procedure. Studies have described an increased risk of perinatal complications including premature and low birth weight infants, although whether these complications occur as a result of the ICSI procedure or secondary to parental infertility remains unknown. Congenital anomalies have also been observed in ICSI-conceived offspring and studies have looked at whether ICSI has an effect on neurodevelopmental outcome. This chapter aims to add to the current understanding of these known outcomes.

Manual of Intracytoplasmic Sperm Injection in Human Assisted Reproduction
With Other Advanced Micromanipulation Techniques to Edit the Genetic and Cytoplasmic Content of the Oocyte
, pp. 87 - 94
Publisher: Cambridge University Press
Print publication year: 2021

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