Published online by Cambridge University Press: 02 December 2021
Intracytoplasmic sperm injection (ICSI) is currently the most commonly used assisted reproductive technology (ART) for management of male-factor infertility. Being a relatively new and invasive procedure, limited data are available with regards to the perinatal, neonatal and long-term health of children born as a result of this procedure. Studies have described an increased risk of perinatal complications including premature and low birth weight infants, although whether these complications occur as a result of the ICSI procedure or secondary to parental infertility remains unknown. Congenital anomalies have also been observed in ICSI-conceived offspring and studies have looked at whether ICSI has an effect on neurodevelopmental outcome. This chapter aims to add to the current understanding of these known outcomes.