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Chapter 11 - Embryo Culture and IVF Offspring Outcome

Published online by Cambridge University Press:  15 April 2021

Kersti Lundin
Affiliation:
Sahlgrenska University Hospital, Gothenburg
Aisling Ahlström
Affiliation:
Livio Fertility Center, Gothenburg
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Summary

Since the birth of Louise Brown, the first ‘test tube baby’, in 1978, assisted reproductive technology (ART) has become one of the standard treatments for couples with subfertility problems. Today, it is estimated that 8 million children have been born via ART worldwide and up to 6% of newborns in Europe are conceived via this technique (Adamson et al., 2019). Surprisingly, relatively little is known about the short- and especially long-term effects of ART manipulations on the health risks for the children.

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Publisher: Cambridge University Press
Print publication year: 2021

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References

Adamson, GD, Dyer, S, Chambers, et al. ICMART preliminary world report 2015. Hum Repro. 2019;34 : i65.Google Scholar
Berntsen, S, Soderstrom-Anttila, V, Wennerholm, UB, et al. The health of children conceived by ART: ‘the chicken or the egg?Hum Reprod Update. 2019;25 :137158.CrossRefGoogle ScholarPubMed
Bouillon, C, Léandri, R, Desch, L, et al. Does embryo culture medium influence the health and development of children born after in vitro fertilization? PLoS ONE. 2016;11:e0150857.CrossRefGoogle ScholarPubMed
Calle, A, Fernandez-Gonzalez, R, Ramos-Ibeas, P, et al. Long-term and transgenerational effects of in vitro culture on mouse embryos. Theriogenology. 2012;77 :785793.CrossRefGoogle ScholarPubMed
De Vos, A, Van Landuyt, L, Santos-Ribeiro, S, et al. Cumulative live birth rates after fresh and vitrified cleavage-stage versus blastocyst-stage embryo transfer in the first treatment cycle. Hum Reprod. 2016;31:24422449.CrossRefGoogle ScholarPubMed
Dumoulin, JC, Land, JA, Van Montfoort, AP, et al. Effect of in vitro culture of human embryos on birthweight of newborns. Hum Reprod. 2010;25 :605612.CrossRefGoogle ScholarPubMed
Duranthon, V, Chavatte-Palmer, P. Long term effects of ART: What do animals tell us? Mol Reprod Dev. 2018;85 :348368.CrossRefGoogle ScholarPubMed
Ealy, AD, Wooldridge, LK, McCoski, SR. Board Invited Review: Post-transfer consequences of in vitro-produced embryos in cattle. J Anim Sci. 2019;97 :25552568.CrossRefGoogle ScholarPubMed
Feuer, SK, Rinaudo, PF. Physiological, metabolic and transcriptional postnatal phenotypes of in vitro fertilization (IVF) in the mouse. J Dev Orig Health Dis. 2017;8 :403410.CrossRefGoogle Scholar
Gardner, DK, Kelley, RL. Impact of the IVF laboratory environment on human preimplantation embryo phenotype. J Dev Orig Health Dis. 2017;8 :418435.CrossRefGoogle ScholarPubMed
Glujovsky, D, Farquhar, C, Quinteiro Retamar, AM, Alvarez Sedo, CR, Blake, D. Cleavage stage versus blastocyst stage embryo transfer in assisted reproductive technology. Cochrane Database Syst Rev. 2016;CD002118.CrossRefGoogle Scholar
Guo, XY, Liu, XM, Jin, L, et al. Cardiovascular and metabolic profiles of offspring conceived by assisted reproductive technologies: a systematic review and meta-analysis. Fertil Steril. 2017;107 : 22631 e625.CrossRefGoogle ScholarPubMed
Kleijkers, SH, Mantikou, E, Slappendel, E., et al. Influence of embryo culture medium (G5 and HTF) on pregnancy and perinatal outcome after IVF: a multicenter RCT. Hum Reprod. 2016;31 :22192230.CrossRefGoogle ScholarPubMed
Mani, S, Mainigi, M. Embryo culture conditions and the epigenome. Semin Reprod Med. 2018;36 :211220.CrossRefGoogle ScholarPubMed
Pinborg, A, Wennerholm, UB, Romundstad, LB, et al. Why do singletons conceived after assisted reproduction technology have adverse perinatal outcome? Systematic review and meta-analysis. Hum Reprod Update. 2013;19 :87104.CrossRefGoogle ScholarPubMed
Roseboom, TJ. Developmental plasticity and its relevance to assisted human reproduction. Hum Reprod. 2018;33 :546552.CrossRefGoogle ScholarPubMed
Salilew-Wondim, D, Tesfaye, D, Hoelker, M, Schellander, K. Embryo transcriptome response to environmental factors: implication for its survival under suboptimal conditions. Anim Reprod Sci. 2014;149 :3038.CrossRefGoogle ScholarPubMed
Velazquez, MA, Sheth, B, Smith, SJ, Eckert, JJ, Osmond, C, Fleming, TP. Insulin and branched-chain amino acid depletion during mouse preimplantation embryo culture programmes body weight gain and raised blood pressure during early postnatal life. Biochim Biophys Acta Mol Basis Dis. 2018;1864 :590600.CrossRefGoogle ScholarPubMed
Vrooman, LA, Bartolomei, MS. Can assisted reproductive technologies cause adult-onset disease? Evidence from human and mouse. Reprod Toxicol. 2017;68 :7284.CrossRefGoogle ScholarPubMed
Wale, PL, Gardner, DK. The effects of chemical and physical factors on mammalian embryo culture and their importance for the practice of assisted human reproduction. Hum Reprod Update. 2016;22 :222.CrossRefGoogle ScholarPubMed
Wang, X, Du, M, Guan, Y, Wang, B, Zhang, J, Liu, Z. Comparative neonatal outcomes in singleton births from blastocyst transfers or cleavage-stage embryo transfers: a systematic review and meta-analysis. Reprod Biol Endocrinol. 2017;15 :36.CrossRefGoogle ScholarPubMed
Wrenzycki, C. Gene expression analysis and in vitro production procedures for bovine preimplantation embryos: Past highlights, present concepts and future prospects. Reprod Domest Anim. 2018;53 Suppl 2:1419.CrossRefGoogle ScholarPubMed
Zandstra, H, Brentjens, L, Spauwen, B, et al. Association of culture medium with growth, weight and cardiovascular development of IVF children at the age of 9 years. Hum Reprod. 2018;33:16451656.CrossRefGoogle ScholarPubMed
Zandstra, H, Van Montfoort, AP, Dumoulin, JC. Does the type of culture medium used influence birthweight of children born after IVF? Hum Reprod. 2015;30 :530542.CrossRefGoogle ScholarPubMed

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