Skip to main content Accessibility help
×
Hostname: page-component-788cddb947-tr9hg Total loading time: 0 Render date: 2024-10-08T03:10:34.705Z Has data issue: false hasContentIssue false

Chapter 18 - Selective estrogen receptor modulators used for postmenopausal women

Published online by Cambridge University Press:  05 September 2015

Nick Panay
Affiliation:
Queen Charlotte’s Hospital, London
Paula Briggs
Affiliation:
Sefton Community Sexual Health Service, Liverpool
Gab Kovacs
Affiliation:
Monash University, Victoria
Get access

Summary

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Chapter
Information
Managing the Menopause
21st Century Solutions
, pp. 142 - 148
Publisher: Cambridge University Press
Print publication year: 2015

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Maximov, PY, Lee, TM, Jordan, VC. The discovery and development of selective estrogen receptor modulators (SERMs) for clinical practice. Curr Clin Pharmacol 2013; 8: 135–55.CrossRefGoogle ScholarPubMed
Burstein, HJ, Temin, S, Anderson, H, et al. Adjuvant endocrine therapy for women with hormone receptor-positive breast cancer: American Society of Clinical Oncology Clinical Practice Guideline Focused Update. Published online before print May 27, 2014.Google Scholar
Davies, C, Pan, H, Godwin, J, et al. Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial. Lancet 2013; 381: 805–16.CrossRefGoogle Scholar
Harvey, HA, Kimura, M, Hajba, A. Toremifene: an evaluation of its safety profile. Breast 2006; 15: 142–57.CrossRefGoogle ScholarPubMed
Vogel, VG, Costantino, JP, Wickerham, DL, et al. Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: the NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trial. JAMA 2006; 295: 2727–41.CrossRefGoogle ScholarPubMed
Ettinger, B, Black, DM, Mitlak, BH, et al. Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators. JAMA 1999; 282: 637–45.CrossRefGoogle ScholarPubMed
Portman, DJ, Bachmann, GA, Simon, JA. Ospemifene, a novel selective estrogen receptor modulator for treating dyspareunia associated with postmenopausal vulvar and vaginal atrophy. Menopause 2013; 20: 623–30.Google ScholarPubMed
Simon, JA, Lin, VH, Radovich, C, Bachmann, GA, Ospemifene study group. One-year long-term safety extension study of ospemifene for the treatment of valvar and vaginal atrophy in postmenopausal women with a uterus. Menopause 2012; 20: 418–27.Google Scholar
Lobo, RA, Pinkerton, JV, Gass, MLS, et al. Evaluation of bazedoxifene/conjugated estrogens for the treatment of menopausal symptoms and effects on metabolic bone parameters and overall safety profile. Fertil Steril 2009; 92: 1025–38.CrossRefGoogle Scholar
Pinkerton, JV, Utian, WH, Constantine, GD, Olivier, S, Pickar, JH. Relief of vasomotor symptoms with the tissue-selective estrogen complex containing bazedoxifene/conjugated estrogens: a randomized, controlled trial. Menopause 2009; 16: 1116–24.Google ScholarPubMed
Lindsay, R, Gallagher, JC, Kagan, R, Pickar, JH, Constantine, G. Efficacy of tissue-selective estrogen complex (TSEC) of bazedoxifene/conjugated estrogens (BZX/CE) for osteoporosis prevention in at-risk postmenopausal women. Fertil Steril 2009; 92: 1045–52.CrossRefGoogle Scholar
Pinkerton, JV, Harvey, JA, Lindsay, R, et al.; SMART-5 Investigators. Effects of bazedoxifene/conjugated estrogens on the endometrium and bone: a randomized trial. J Clin Endocrinol Metab 2014; 99: E189–98 [Epub Jan 17, 2014].CrossRefGoogle ScholarPubMed
Kagan, R, Williams, RS, Pan, K, Mirkin, S, Pickar, JH. A randomized, placebo- and active-controlled trial of bazedoxifene/conjugated estrogens (BZA/CE) for treatment of moderate to severe vulvar/vaginal atrophy in postmenopausal women. Menopause 2010; 17: 281–9.Google ScholarPubMed
Pinkerton, JV, Harvey, JA, Pan, K, et al. Breast effects of bazedoxifene-conjugated estrogens: a randomized controlled trial. Obstet Gynecol 2013; 121: 959–68.CrossRefGoogle ScholarPubMed
Archer, DF, Lewis, V, Carr, BR, Olivier, S, Pickar, JH. Bazedoxifene/conjugated estrogens (BZA/CE): incidence of uterine bleeding in postmenopausal women. Fertil Steril 2009; 92: 1039–44.CrossRefGoogle ScholarPubMed
Pickar, JH, Yeh, I-T, Bachmann, G, Speroff, L. Endometrial effects of a tissue selective estrogen complex (TSEC) containing bazedoxifene/conjugated estrogens as a menopausal therapy. Fertil Steril 2009; 92: 1018–24.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×