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Section 2 - Menstrual Disorders

Published online by Cambridge University Press:  24 November 2021

Tahir Mahmood
Victoria Hospital, Kirkcaldy
Charles Savona-Ventura
University of Malta, Malta
Ioannis Messinis
University of Thessaly, Greece
Sambit Mukhopadhyay
Norfolk & Norwich University Hospital, UK
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Publisher: Cambridge University Press
Print publication year: 2021

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Goldenring, JM, Rosen, DS. Getting into adolescent heads: an essential update. Contemp Pediatr 2004;21:6490.Google Scholar
Wood, PL. Cosmetic genital surgery in children and adolescents. Best Pract Res Clin Obstet Gynaecol 2018;48:137146.CrossRefGoogle ScholarPubMed
Ibáñez, L, Oberfield, SE, Witchel, S, et al. An international consortium update: pathophysiology, diagnosis, and treatment of polycystic ovarian syndrome in adolescence. Horm Res Paediatr 2017;88:371395.CrossRefGoogle Scholar
Teede, H, Misso, M, Costello, M, et al. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Fertil Steril 2018;110:364379.CrossRefGoogle ScholarPubMed
Sultan, C, Gaspari, L, Maimoun, L, Kalfa, N, Paris, F. Disorders of puberty. Best Pract Res Clin Obstet Gynaecol 2018;48:6289.CrossRefGoogle ScholarPubMed
Carel, JC, Eugster, EA, Rogol, A, et al. Consensus statement on the use of gonadotropin-releasing hormone analogs in children. Pediatrics 2009;123:e752e762.CrossRefGoogle ScholarPubMed
Consortium on the Management of Disorders of Sex Development. Clinical guidelines for the management of disorders of sex development in childhood, 2006. Available at: Scholar
Hughes, IA, Houk, C, Ahmed, SF, et al. Consensus statement on management of intersex disorders. Arch Dis Childhood 2006;91:554563.CrossRefGoogle ScholarPubMed
Witchel, SF. Congenital adrenal hyperplasia. J Pediatric Adolesc Gynecol 2017;30:520534.CrossRefGoogle ScholarPubMed
Phyllis, W, Speiser, R, Azziz, L, et al. Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2010;95:41334160.Google Scholar
Hughes, LA, Davies, JD, Bunch, TI, et al. Androgen insensitivity syndrome. Lancet 2012;380:14191428.CrossRefGoogle ScholarPubMed
Hayes, L, Creighton, SM. Review: prepubertal vaginal discharge. TOG 2007;9:159163.CrossRefGoogle Scholar
Kirtschig, G, Becker, K, Günthert, D, et al. Evidence-based (S3) guideline on (anogenital) lichen sclerosus. J Eur Acad Dermatol Venerol 2015;29: e1e43.CrossRefGoogle ScholarPubMed
Lewis, FM, Tatnall, FM, Velangi, SS, et al. British Association of Dermatologists guidelines for the management of lichen sclerosus, Br J Dermatol 2018;178:839853CrossRefGoogle ScholarPubMed
Van Eyk, N, Allen, L, Giesbrecht, E, et al. Pediatric vulvovaginal disorders: a diagnostic approach and review of the literature. J Obstet Gynaecol Can 2009;31:850862Google Scholar
Gallion, HR, Milram, LJ, Littrel, LL. Genital findings in cases of child sexual abuse: genital vs vaginal penetration. J Pediatr Adolesc Gynecol 2016;29:604611.CrossRefGoogle ScholarPubMed
Adams, JA, Kellogg, ND, Farst, KJ, et al. Updated guidelines for the medical assessment and care of children who may have been sexually abused. J Pediatr Adolesc Gynecol 2016;29: 8187.CrossRefGoogle ScholarPubMed
Adams, JA, Farst, KJ, Kellogg, ND. Interpretation of medical findings in suspected child sexual abuse: an update for 2018. J Pediatr Adolesc Gynecol 2018;31:225231.CrossRefGoogle ScholarPubMed
Ebert, AD, Fuhr, N, Metthias, D Histological confirmation of endometriosis in a 9-year old girl suffering from unexplained cyclic pelvic pain since the eighth year of life. Gynecol Obstet Invest 2009;67:158161.CrossRefGoogle Scholar
Dun, E, Kho, K, Morozov, V, et al. Endometriosis in adolescents. J Soc Laparoendoscopic Surg 2015;19:18Google ScholarPubMed
Simpson, JL, Ekias, S, Malinak, LR, Buttram, VC Jr. Hereditable aspects of endometriosis. 1. Genetic studies. Am J Obstet Gynaecol 1981;137;327331.CrossRefGoogle Scholar
Santos, X, Cass, D, Dietrich, J. Outcome following detorsion of torsed adnexa in children. J Pediatr Adolesc Gynecol 2015;28:136138.CrossRefGoogle ScholarPubMed
Leserman, J, Li, Z, Drossman, DA, Hu, YJ. Selected symptoms associated with sexual and physical abuse history among female patients with gastrointestinal disorders: the impact on subsequent health care visits. Psychol Med 1998;28:417422.CrossRefGoogle ScholarPubMed
Salama, M, Isachenko, V, Isachenko, E, Rahimi, G, Mallmann, P. Updates in preserving reproductive potential of prepubertal girls with cancer: systematic review. Crit Rev Oncol Hematol 2016;103:1021.CrossRefGoogle ScholarPubMed


NICE. Heavy menstrual bleeding: assessment and management. NICE guideline NG88. 2018.Google Scholar
Munro, MG, Critchley, HOD, Fraser, IS. The two FIGO systems for normal and abnormal uterine bleeding symptoms and classification of causes of abnormal uterine bleeding in the reproductive years: 2018 revisions. Int J Gynaecol Obstet 2018;143:393–408.CrossRefGoogle Scholar
Fraser, IS, Mansour, D, Breymann, C, et al. Prevalence of heavy menstrual bleeding and experiences of affected women in a European patient survey. Int J Gynaecol Obstet 2015;128:196200.CrossRefGoogle Scholar
Chodankar, R, Harpur, A, Mahmood, TA. Heavy menstrual bleeding. Obstet Gynaecol Reprod Med 2016;28:196202.CrossRefGoogle Scholar
Hapangama, DK, Bulmer, JN. Pathophysiology of heavy menstrual bleeding. Women Health (Lond) 2016;12:313.CrossRefGoogle ScholarPubMed
Tsiligiannis, SE, Zaitseva, M, Coombs, PR, et al. Fibroid-associated heavy menstrual bleeding: correlation between clinical features, Doppler ultrasound assessment of vasculature, and tissue gene expression profiles. Reprod Sci 2013;20:361370.CrossRefGoogle ScholarPubMed
Bano, R, Datta, S, Mahmood, TA. Heavy menstrual bleeding. Obstet Gynaecol Reprod Med 2016;26:167174.CrossRefGoogle Scholar
Bryant-Smith, Lethaby, AC Farquhar, A Hickey M, C. Antifibrinolytics for heavy menstrual bleeding. Cochrane Database Syst Rev 2018;4:CD000249.Google ScholarPubMed
Davies, J, Kadir, RA. Heavy menstrual bleeding: an update on management. Thromb Res 2017;151(Suppl. 1):S70S77.CrossRefGoogle ScholarPubMed
Dockeray, CJ, Sheppard, BL, Daly, L, Bonnar, J. The fibrinolytic enzyme system in normal menstruation and excessive uterine bleeding and the effect of tranexamic acid. Eur J Obstet Gynecol Reprod Biol 1987;24:309318.CrossRefGoogle ScholarPubMed
Maybin, JA, Critchley, HO. Medical management of heavy menstrual bleeding. Womens Health (Lond) 2016;12:2734.CrossRefGoogle ScholarPubMed
Cameron, IT, Haining, R, Lumsden, MA, Thomas, VR, Smith, SK. The effects of mefenamic acid and norethisterone on measured menstrual blood loss. Obstet Gynecol 1990;76:8588.Google ScholarPubMed
Lethaby, A, Hussain, M, Rishworth, JR, Rees, MC. Progesterone or progestogen‐releasing intrauterine systems for heavy menstrual bleeding. Cochrane Database Syst Rev 2015;4:CD002126.Google Scholar
Younas, K, Hadoura, E, Majoko, F, Bunkheila, A. A review of evidence-based management of uterine fibroids. TOG 2016;18:3342.CrossRefGoogle Scholar
Lethaby, A, Wise, MR, Weterings, MAJ, Bofill Rodriguez, M, Brown, J. Combined hormonal contraceptives for heavy menstrual bleeding. Cochrane Database Syst Rev 2019;2:CD000154.Google ScholarPubMed
MacGregor, EA, Guillebaud, J. The 7-day contraceptive hormone-free interval should be consigned to history. BMJ Sex Reprod Health 2018;44:214220.CrossRefGoogle Scholar
Todd, N, Black, A. Contraception for adolescents. J Clin Res Pediatr Endocrinol 2020;12(Suppl. 1):2840.CrossRefGoogle ScholarPubMed
Faculty of Sexual and Reproductive Health (FSRH). Clinical guideline: combined hormonal contraception (January 2019, amended July 2019).Google Scholar
Irvine, GA, Campbell-Brown, MB, Lumsden, MA, et al. Randomised comparative trial of the levonorgestrel intrauterine system and norethisterone for treatment of idiopathic menorrhagia. Br J Obstet Gynaecol 1998;105:592598.CrossRefGoogle ScholarPubMed
Fraser, IS. Treatment of ovulatory and anovulatory dysfunctional uterine bleeding with oral progestogens. Aust N Z J Obstet Gynaecol 1990;30:353356.CrossRefGoogle ScholarPubMed
Lethaby, A, Irvine, G, Cameron, I. Cyclical progestogens for heavy menstrual bleeding. Cochrane Database Syst Rev 2008;1:CD001016.Google Scholar
Day Baird, D, Dunson, DB, Hill, MC, Cousins, D, Schectman, JM. High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence. Am J Obstet Gynecol 2003;188:100107.CrossRefGoogle Scholar
Saridogan, E. Surgical treatment of fibroids in heavy menstrual bleeding. Womens Health (Lond) 2016;12:5362.CrossRefGoogle ScholarPubMed
Famuyide, A. Endometrial ablation. J Minim Invasive Gynecol 2018;25:299307.CrossRefGoogle ScholarPubMed
Moss, J, Christie, A. Uterine artery embolization for heavy menstrual bleeding. Womens Health (Lond) 2016;12:7177.CrossRefGoogle ScholarPubMed
Van der Meij, E, Emanuel, MH. Hysterectomy for heavy menstrual bleeding. Womens Health (Lond) 2016;12:6369.CrossRefGoogle ScholarPubMed


Foth, D, Röhl, F-W, Friedrich, C. Symptoms of uterine myomas: data of an epidemiological study in Germany. Arch Gynecol Obstet 2017;295:415426.CrossRefGoogle ScholarPubMed
Ahrendt, HJ, Tylkoski, H, Rabe, T. Prevalence of uterine myomas in women in Germany: data of an epidemiological study. Arch Gynecol Obstet 2016;293:12431253.CrossRefGoogle ScholarPubMed
Huyck, KL, Panhuysen, CIM, Cuenco, KT. The impact of race as a risk factor for symptom severity and age at diagnosis of uterine leiomyomata among affected sisters. Am J Obstet Gynecol 2008;198:168 e1168 e9.CrossRefGoogle ScholarPubMed
Pavone, D, Clemenza, S, Sorbi, F, et al. Epidemiology and risk factors of uterine fibroids. Best Pract Res Clin Obstet Gynaecol 2018;46:311.CrossRefGoogle ScholarPubMed
Parker, WH. The utility of MRI for the surgical treatment of women with uterine fibroid tumors. Am J Obstet Gynecol 2012;206:3136.CrossRefGoogle ScholarPubMed
Munro, MG, Critchley, HOD, Broder, MS. FIGO classification system (PALM-COEIN) for causes of abnormal uterine bleeding in nongravid women of reproductive age. Int J Gynaecol Obstet 2011;113:313.CrossRefGoogle ScholarPubMed
Dubuisson, J. The current place of mini-invasive surgery in uterine leiomyoma management. J Gynecol Obstet Hum Reprod 2019;48:7781.CrossRefGoogle ScholarPubMed
Bryant-Smith, AC, Lethaby, A, Farquhar, C, Hickey, M. Antifibrinolytics for heavy menstrual bleeding. Cochrane Database Syst Rev 2018;4:CD000249.Google ScholarPubMed
Qin, J, Yang, T, Kong, F, Zhou, Q. Oral contraceptive use and uterine leiomyoma risk: a meta-analysis based on cohort and case-control studies. Arch Gynecol Obstet 2013;288:139148.CrossRefGoogle ScholarPubMed
Schreiber, CA, Teal, SB, Blumenthal, PD, Keder, LM, et al. Bleeding patterns for the Liletta® levonorgestrel 52 mg intrauterine system. Eur J Contracept Reprod Health Care 2018;23:116120.CrossRefGoogle ScholarPubMed
Römer, TDK, Foth, D, Hadji, P, et al. Symptomatischer Uterus myomatosus. Zielgerichtete medikamentöse Therapie Frauenarzt 2017;6:497503.Google Scholar
Ali, M, Al-Hendy, A. Uterine fibroid therapy: the pharmacokinetic considerations. Expert Opin Drug Metab Toxicol 2018;14:887889.CrossRefGoogle ScholarPubMed
Sinai Talaulikar, V. Medical therapy for fibroids: an overview. Best Pract Res Clin Obstet Gynaecol 2018;46:4856.CrossRefGoogle ScholarPubMed
Singh, SS, Belland, L. Contemporary management of uterine fibroids: focus on emerging medical treatments. Curr Med Res Opin 2015;31:112.CrossRefGoogle ScholarPubMed
Kamath, MS, Kalampokas, EE, Kalampokas, TE. Use of GnRH analogues pre-operatively for hysteroscopic resection of submucous fibroids: a systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol 2014;177:1118.CrossRefGoogle ScholarPubMed
Donnez, J, Tomaszewski, J, Vázquez, F, et al. Ulipristal acetate versus leuprolide acetate for uterine fibroids. N Engl J Med 2012;366:421432.CrossRefGoogle ScholarPubMed
Donnez, J, Vázquez, F, Tomaszewski, J, et al. Long-term treatment of uterine fibroids with ulipristal acetate. Fertil Steril 2014;101:1565–73 e1–18.CrossRefGoogle ScholarPubMed
Rabe, T, Sanger, N, Ebert, AD, et al. Die Anwendung von Selektiven Progesteron-rezeptor-modulatoren (SPrms) zur medikamentösen behandlung von uterusmyomen: ulipristalacetat im Fokus. J Reproduktionsmed Endokrinol_Online 2017;14:113122.Google Scholar
Donnez, J, Donnez, O, Matule, D, et al. Long-term medical management of uterine fibroids with ulipristal acetate. Fertil Steril 2016;105:165173 e4.CrossRefGoogle ScholarPubMed
Donnez, J. Liver injury and ulipristal acetate: an overstated tragedy? Fertil Steril 2018;110:593595.CrossRefGoogle ScholarPubMed
Kriplani, A, Srivastava, A, Kulshrestha, V, et al. Efficacy of ormeloxifene versus oral contraceptive in the management of abnormal uterine bleeding due to uterine leiomyoma. J Obstet Gynaecol Res 2016;42:17441752.CrossRefGoogle ScholarPubMed
Fauser, BC, Donnez, J, Bouchard, P, et al. Safety after extended repeated use of ulipristal acetate for uterine fibroids. PLoS One 2017;12:e0173523.CrossRefGoogle ScholarPubMed
AAGL Advancing Minimally Invasive Gynecology Worldwide. AAGL position statement: route of hysterectomy to treat benign uterine disease. J Minim Invasive Gynecol 2011;18:13.CrossRefGoogle Scholar
Miskry, T, Magos, A. Randomized, prospective, double-blind comparison of abdominal and vaginal hysterectomy in women without uterovaginal prolapse. Acta Obstet Gynecol Scand 2003;82:351358.CrossRefGoogle ScholarPubMed
Andres, MP, Borrelli, GM, Abrao, MS. Advances on minimally invasive approach for benign total hysterectomy: a systematic review. F1000Res 2017;6:1295.CrossRefGoogle ScholarPubMed
Taylan, E, Sahin, C, Zeybek, B, Akdemir, A. Contained morcellation: review of current methods and future directions. Front Surg 2017;4:15.CrossRefGoogle ScholarPubMed
Sesti, F, Ruggeri, V, Pietropolli, A, Piccione, E. Laparoscopically assisted vaginal hysterectomy versus vaginal hysterectomy for enlarged uterus. JSLS 2008;12:246251.Google ScholarPubMed
Cezar, C, Becker, S, di Spiezio Sardo, A. Laparoscopy or laparotomy as the way of entrance in myoma enucleation. Arch Gynecol Obstet 2017;296:709720.CrossRefGoogle ScholarPubMed
Young, M, Mikhail, LN. Uterine Fibroid Embolization. Treasure Island (FL): StatPearls, 2018.Google Scholar
Sridhar, D, Kohi, MP. Updates on MR-guided focused ultrasound for symptomatic uterine fibroids. Semin Intervent Radiol 2018;35:1722.Google ScholarPubMed


Brosens, I, Gordts, S, Benagiano, G. Endometriosis in adolescents is a hidden, progressive and severe disease that deserves attention, not just compassion. Hum Reprod 2013;28:20262031.CrossRefGoogle Scholar
Fallon, J. Endometriosis in youth. JAMA 1946;131:14051406.CrossRefGoogle ScholarPubMed
Evers, JLH. Is adolescent endometriosis a progressive disease that needs to be diagnosed and treated? Hum Reprod 2013;28:2023.CrossRefGoogle Scholar
Goldstein, DP, De Cholnoky, C, Emansi, SJ. Adolescent endometriosis. J Adolesc Health Care 1980;1:3741.CrossRefGoogle ScholarPubMed
Marsh, EE, Laufer, MR. Endometriosis in premenarcheal girls who do not have an associated obstructive anomaly. Fertil Steril 2005;83:758760.CrossRefGoogle Scholar
Janssen, EBR, Hoppenbrouwers, AC, Meuleman, K, Hooghe, CD. Prevalence of endometriosis diagnosed by laparoscopy in adolescents with dysmenorrhea or chronic pelvic pain: a systematic review. Hum Reprod Update 2013;19:570582.CrossRefGoogle ScholarPubMed
Laufer, MR, Goitein, L, Bush, M, Cramer, DW, Emans, SJ. Prevalence of endometriosis in adolescent girls with chronic pelvic pain not responding to conventional therapy. J Pediatr Adolesc Gynecol 1997;10:199202.CrossRefGoogle Scholar
Yeung, P, Gupta, S, Gieg, S. Endometriosis in adolescents: a systematic review. J Endometriosis Pelvic Pain Disord 2016;9:1729.CrossRefGoogle Scholar
Zannoni, L, Forno, SD, Paradisi, R, Seracchioli, R. Endometriosis in adolescence: practical rules for an earlier diagnosis. Pediatr Ann 2016;45:332335.CrossRefGoogle ScholarPubMed
Matalliotakis, M, Goulielmos, GM, Matalliotaki, C, et al. Endometriosis in adolescents and young girls: report on a series of 55 cases. J Pediatr Adolesc Gyecol 2017;30:568570.CrossRefGoogle Scholar
Audebert, A, Lecointre, L, Afors, K, et al. Adolescent endometriosis: report of a series of 55 cases with a focus on clinical presentation and long-term issues. J Minim Invasive Gynecol 2015;22:834840.CrossRefGoogle ScholarPubMed
Unger, CA, Laufer, MR. Progression of endometriosis in non-medically managed adolescents: a case series. J Pediatr Adolesc Gynecol 2011;24:e21e23.CrossRefGoogle ScholarPubMed
Gordts, S, Puttemans, P, Gordts, S, Brosens, I. Ovarian endometrioma in the adolescent: a plea for early-stage diagnosis and full surgical treatment. Gynecol Surg 2015;12:2130.CrossRefGoogle ScholarPubMed
Fong, YF, Hon, SK, Low, LL, Lim Mei Xian, K. The clinical profile of young and adolescent women with laparoscopically diagnosed endometriosis in a Singapore tertiary hospital. Taiwan J Obstet Gynecol 2017;56:181183.CrossRefGoogle Scholar
Uğur, M, Turan, C, Mungan, T, et al. Endometriosis in association with Müllerian anomalies. Gynecol Obstet Invest 1995;40:261264.CrossRefGoogle ScholarPubMed
Nawroth, F, Rahimi, G, Nawroth, C, et al. Is there an association between septate uterus and endometriosis? Hum Reprod 2006;21:542544.CrossRefGoogle ScholarPubMed
Yang, YP, Wang, Y, Jie Yang, JY, Wang, S, Lang, JH. Adolescent endometriosis in China: a retrospective analysis of 63 cases. J Pediatr Adolesc Gynecol 2012;25:295299.CrossRefGoogle ScholarPubMed
Ophir, J, Cespedes, I, Ponnekanti, H, Yazdi, Y, Li, X. Elastography: a quantitative method for imaging the elasticity of biological tissues. Ultrason Imaging 1991;13:111134.CrossRefGoogle ScholarPubMed
Holland, TK, Yazbek, J, Cutner, A, et al. Value of transvaginal ultrasound in assessing severity of pelvic endometriosis. Ultrasound Obstet Gynecol 2010;36:241248.CrossRefGoogle ScholarPubMed
Stratton, P, Winkel, C, Premkumar, A, et al. Diagnostic accuracy of laparoscopy, magnetic resonance imaging, and histopathologic examination for the detection of endometriosis. Fertil Steril 2003;79:10781085.CrossRefGoogle ScholarPubMed
Hughesdon, PE. The structure of endometrial cysts of the ovary. J Obstet Gynaecol Br Emp 1957;64:481487.CrossRefGoogle ScholarPubMed
Brosens, I, Campo, R, Gordts, S. Office hydrolaparoscopy for the diagnosis of endometriosis and tubal infertility. Curr Opin Obstet Gynecol 1999;11:371377.CrossRefGoogle Scholar
Brosens, I, Gordts, S, Puttemans, P, Benagiano, G. Pathophysiology proposed as the basis for modern management of the ovarian endometrioma. Reprod Biomed Online 2014;28:232238.CrossRefGoogle ScholarPubMed
Sanchez, AM, Vigano, P, Somigliana, E, et al. The distinguishing cellular and molecular features of the endometriotic ovarian cyst: from pathophysiology to the potential endometrioma-mediated damage to the ovary. Hum Reprod Update 2014;20:217230.CrossRefGoogle ScholarPubMed
Fukunaga, M. Smooth muscle metaplasia in ovarian endometriosis. Histopathology 2000;36:348352.CrossRefGoogle ScholarPubMed
Zhang, Q, Duan, J, Olson, M, Fazleabas, A, Guo, SW. Cellular changes consistent with epithelial-mesenchymal transition and fibroblast-to-myofibroblast trans-differentiation in the progression of experimental endometriosis in baboons. Reprod Sci 2016;23:14091421.CrossRefGoogle Scholar
Lévy, JM, Rosenthal, R, Dellenbach, P, Pequenot, JP. Crise génitale du nouveau-né. Répercussion de certains facteurs maternels ou gravidiques sur la fréquence des métrorragies néonatales [Genital crisis in the new born: repercussion of certain maternal or pregnancy factors on the frequency of neonatal metrorrhagia]. Arch Fr Pediatr 1964;21:819827.Google Scholar
Kaiser, R, Grässel, G. Frequenz und Stärke der uterinen Neugeborenenblutung [Incidence and intensity of uterine bleeding in the neonate]. Geburtshilfe Frauenheilkd 1974;34:644648.Google Scholar
Huber, A. Häufigkeit der physiologischen vaginalen Neugeborenenblutung [Frequency of physiologic vaginal haemorrhage in the new born]. Zentralbl Gynakol 1976;98:10171020.Google Scholar
Berić, BM, Prodanović, Z, Mitrović, M, Curcić, O. Uterino krvavljenje u novorodene dece [Uterine haemorrhage in new-borns]. Jugosl Ginekol Perinatol 1985;25:8991.Google Scholar
Rosa, P. Endocrinologie sexuelle du fœtus féminin [Sexual Endocrinology of Female Foetuses]. Vol. 1. Paris: Masson et Cie; 1955.Google Scholar
Ober, WB, Bernstein, J. Observations on the endometrium and ovary in the newborn. Pediatrics 1955;16:445460.Google ScholarPubMed
Benagiano, G, Brosens, I. In utero exposure and endometriosis. J Matern Fetal Neonatal Med 2014;27:303308.CrossRefGoogle ScholarPubMed
Brosens, I, Brosens, JJ, Benagiano, G. Neonatal uterine bleeding as antecedent of pelvic endometriosis. Hum Reprod 2013;28:28932897.CrossRefGoogle ScholarPubMed
Gargett, CE, Schwab, KE, Brosens, JJ, et al. Potential role of endometrial stem/progenitor cells in the pathogenesis of early-onset endometriosis. Mol Hum Reprod 2014;20:591598.CrossRefGoogle ScholarPubMed
Rahmioglu, N, Nyholt, DR, Morris, AP, et al. Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets. Hum Reprod Update 2014;20:702716.CrossRefGoogle ScholarPubMed
Mendiola, J, Sánchez-Ferrer, ML, Jiménez-Velázquez, R, et al. Endometriomas and deep infiltrating endometriosis in adulthood are strongly associated with anogenital distance, a biomarker for prenatal hormonal environment. Hum Reprod 2016;31:23772383.CrossRefGoogle ScholarPubMed
ESHRE. Guidelines for the diagnosis and treatment of endometriosis, 2016. Available at: (accessed 2 January 2019).Google Scholar
Tafi, E, Leone Roberti Maggiore, U, Alessandri, F, et al. Advances in pharmacotherapy for treating endometriosis. Expert Opin Pharmacother 2015;16:24652483.CrossRefGoogle ScholarPubMed
Brown, J, Crawford, TJ, Datta, S, Prentice, A. Oral contraceptives for pain associated with endometriosis. Cochrane Database Syst Rev 2018;22;5: CD001019.Google Scholar
Brosens, I, Van Ballaer, P, Puttemans, P, Deprest, J. Reconstruction of the ovary containing large endometriomas by an extraovarian endosurgical technique. Fertil Steril 1996;66:517521.CrossRefGoogle ScholarPubMed


RCOG. Chronic pelvic pain, initial management. Green-top Guideline No. 41. February 2012.Google Scholar
RCOG. Chronic pelvic pain relief, therapies targeting for the nervous system. Scientific Impact Paper No. 46. January 2015.Google Scholar
Jarrell, JF, Vilos, GA, Allaire, C, et al. Consensus guidelines for the management of chronic pelvic pain: Part I. SOGC clinical practice guidelines. J Obstet Gynaecol Can 2005;27:781801.Google Scholar
Jarrell, JF, Vilos, GA, Allaire, C, et al. Consensus guidelines for the management of chronic pelvic pain: Part II. SOGC Clinical Practice Guidelines. J Obstet Gynaecol Can 2005;27:869887.Google Scholar
RCOG. Management of bladder pain syndrome. Green-top Guideline No. 70. December 2016.Google Scholar
Cheong, YC, Smotra, G, Williams, ACDC. Non-surgical interventions for the management of chronic pelvic pain. Cochrane Database Syst Rev 2014;3:CD008797.Google Scholar
Alderson, P. Irritable bowel syndrome in adults: diagnosis and management of irritable bowel syndrome in primary care. NICE Clinical Guidelines No. 61. 2015. Available at: Scholar
RCOG, Ross, J, Stewart, P. Management of acute pelvic inflammatory disease. Green-top Guideline No. 32. 2008.Google Scholar
Mandal, D, Nunns, D, Byrne, M, et al. Guidelines for the management of vulvodynia. Br J Dermatol 2010;162:11801185.CrossRefGoogle Scholar
Ignacio, EA, Dua, R, Sarin, S, et al. Pelvic congestion syndrome: diagnosis and treatment. Semin Interv Radiol 2008;25:361368.CrossRefGoogle ScholarPubMed
Howard, FM, El-Minawi, AM, Sanchez, RA. Conscious pain mapping by laparoscopy in women with chronic pelvic pain. Obstet Gynecol 2000;96:934939.Google ScholarPubMed
Simpson, LR, Mahmood, T. Medical and surgical management of chronic pelvic pain. Obstet Gynaecol Reprod Med 2016;27:1421.CrossRefGoogle Scholar

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