The long-term outcome of anxiety disorders following stroke has been examined by several investigators (Burvill et al. 1995; Castillo et al. 1995; Astrom 1996; Schultz et al. 1997). The first of our two studies compared patients who developed generalized anxiety disorder (GAD) at the time of the acute stroke with patients who developed GAD 3 or more months after their stroke (Castillo et al. 1995). In this study we wanted to determine first whether there were significant differences in the clinical correlates of GAD among patients who developed anxiety disorder during the acute poststroke period as compared to anxiety disorder which developed several months after the stroke and, second, the duration of the anxiety disorder. The background characteristics of the patients with GAD (diagnosed using diagnostic and statistical manual of mental disorder-III-revised or DSM-III-R criteria, i.e., 4 of 13 anxiety symptoms, including worry or anxious foreboding had to be present) are shown in Table 31.1. Comparison of the background characteristics of early-onset (i.e., present at the initial in-hospital evaluation) and late-onset (i.e., present for the first time 3 or more months following stroke) GAD groups did not reveal significant differences except that patients with early-onset GAD had a higher frequency of personal history of psychiatric disorder or alcohol abuse compared to the late-onset or the no anxiety disorder (control) patients.