Skip to main content Accessibility help
×
Home
Hostname: page-component-99c86f546-8r8mm Total loading time: 0.585 Render date: 2021-11-28T14:42:13.275Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": true, "newCiteModal": false, "newCitedByModal": true, "newEcommerce": true, "newUsageEvents": true }

Chapter 1 - Basic Principles in Clinical Neuroendocrinology I: Receptor Mechanisms

Published online by Cambridge University Press:  24 December 2018

Michael Wilkinson
Affiliation:
Dalhousie University, Nova Scotia
S. Ali Imran
Affiliation:
Dalhousie University, Nova Scotia
Get access
Type
Chapter
Information
Clinical Neuroendocrinology
An Introduction
, pp. 1 - 13
Publisher: Cambridge University Press
Print publication year: 2019

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Barton, M. (2016). Not lost in translation: emerging clinical importance of the G protein-coupled estrogen receptor GPER. Steroids 111, 3745.CrossRefGoogle ScholarPubMed
Ben-Shlomo, A & Melmed, S. (2010). Pituitary somatostatin receptor signaling. Trends Endocr Metab 21, 123133.CrossRefGoogle ScholarPubMed
Bernard, V, Young, J, Chanson, P & Binart, N. (2015). New insights in prolactin: pathological implications. Nat Rev Endocr 11, 265275.CrossRefGoogle ScholarPubMed
Brooks, A J & Waters, M J. (2010). The growth hormone receptor: mechanism of activation and clinical implications. Nat Rev Endocr 6, 515525.CrossRefGoogle ScholarPubMed
Chaidarun, S S, Swearingen, B & Alexander, JM. (1998). Differential expression of estrogen receptor-β (ERβ) in human pituitary tumors: functional interactions with ERα and a tumor-specific splice variant. J Clin Endocr Metab 83, 33083315.Google Scholar
Charmandari, E, Kino, T, Ichijo, T & Chrousos, G P. (2008). Generalized glucocorticoid resistance: clinical aspects, molecular mechanisms, and implications of a rare genetic disorder. J Clin Endocr Metab 93, 15631572.CrossRefGoogle ScholarPubMed
Charmandari, E, Kino, T & Chrousos, G P. (2013). Primary generalized familial and sporadic glucocorticoid resistance (Chrousos syndrome) and hypersensitivity. Endocr Dev 24, 6785.CrossRefGoogle ScholarPubMed
Dodington, D W, Desai, H R & Woo, M. (2018). JAK/STAT – Emerging players in metabolism. Trends Endocr Metab 29, 5565.CrossRefGoogle ScholarPubMed
Engel, J B & Schally, A V. (2007). Drug insight: clinical use of agonists and antagonists of luteinizing-hormone-releasing hormone. Nat Clin Practice Endocr Metab 3, 157167.CrossRefGoogle ScholarPubMed
Farooqi, IS, Wangensteen, T, Collins, S et al. (2007). Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor. New Engl J Med 356, 237247.CrossRefGoogle ScholarPubMed
Fukami, M, Suzuki, E, Igarashi, M, Miyado, M & Ogata, T. (2018). Gain-of-function mutations in G-protein–coupled receptor genes associated with human endocrine disorders. Clin Endocr 88, 351359.CrossRefGoogle ScholarPubMed
Hauser, A S, Attwood, M M, Rask-Andersen, M, Schiöth, H B & Gloriam, D E. (2017). Trends in GPCR drug discovery: new agents, targets and indications. Nat Revs Drug Discovery 16, 829842.CrossRefGoogle ScholarPubMed
Hiort, O. (2013). Clinical and molecular aspects of androgen insensitivity. Endocr Develop 24, 3340.CrossRefGoogle ScholarPubMed
Huang, D, Yang, F, Wang, Y & Guan, X. (2017). Mechanisms of resistance to selective estrogen receptor down-regulator in metastatic breast cancer. Biochim Biophys Acta 1868, 148156.Google ScholarPubMed
Hwa, V. (2016). STAT5B deficiency: impacts on human growth and immunity. Growth Horm IGF Res 28, 1620.CrossRefGoogle ScholarPubMed
Jayasena, C N, Nijher, G M K, Chaudhri, O B et al. (2009). Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis. J Clin Endocr Metab 94, 43154323.CrossRefGoogle ScholarPubMed
Jia, M, Dahlman-Wright, K & Gustafsson, J A. (2015). Estrogen receptor alpha and beta in health and disease. Best Prac Res Clin Endocr Metab 29, 557568.CrossRefGoogle ScholarPubMed
Lania, A G, Mantovani, G & Spada, A. (2006). Mechanisms of disease: mutations of G proteins and G-protein-coupled receptors in endocrine diseases. Nat Clin Practice Endocr Metab 2, 681693.CrossRefGoogle ScholarPubMed
Manoranjan, B, Salehi, F, Scheithauer, B W, Rotondo, F, Kovacs, K & Cusimano, M D. (2010). Estrogen receptors alpha and beta immunohistochemical expression: clinicopathological correlations in pituitary adenomas. Anticancer Res 30, 28972904.Google ScholarPubMed
McEwan, I J & Brinkmann, A O. (2016). Androgen physiology: Receptor and metabolic disorders. In: Endocrinology of Male Reproduction; Simoni, M & Huhtaniemi, I T, Eds. Berlin: Springer. www.Endotext.org.Google Scholar
Monteleone, P, Mascagni, G, Giannini, A, Genazzani, A R & Simoncini, T. (2018). Symptoms of menopause – global prevalence, physiology and implications. Nat Rev Endocr 14, 199215.CrossRefGoogle ScholarPubMed
Myers Jr., M G, Leibel, R L, Seeley, R J & Schwartz, M W. (2010). Obesity and leptin resistance: distinguishing cause from effect. Trends Endocr Metab 21, 643651.CrossRefGoogle Scholar
Neumann, E, Khawaja, K & Müller-Ladner, U. (2014). G protein-coupled receptors in rheumatology. Nat Rev Rheumatol 10, 429436.CrossRefGoogle ScholarPubMed
Ortiga-Carvalho, T M, Sidhaye, A R & Wondisford, F E. (2014). Thyroid hormone receptors and resistance to thyroid hormone disorders. Nat Rev Endocr 10, 582591.CrossRefGoogle ScholarPubMed
Paterni, I, Granchi, C, Katzenellenbogen, J A & Minutolo, F. (2014). Estrogen receptors alpha (ERα) and beta (ERβ): subtype-selective ligands and clinical potential. Steroids 90, 1329.CrossRefGoogle ScholarPubMed
Prossnitz, ER & Barton, M. (2011). The G-protein-coupled estrogen receptor GPER in health and disease. Nat Rev Endocr 7, 715726.CrossRefGoogle ScholarPubMed
Rodriguez, J M, Monsalves-Alvarez, M, Henriquez, S, Llanos, M N & Troncoso, R. (2016). Glucocorticoid resistance in chronic diseases. Steroids 115, 182192.CrossRefGoogle ScholarPubMed
Rosenfeld, R G, Belgorosky, A, Camacho-Hubner, C, Savage, M O, Wit, J M & Hwa, V. (2007). Defects in growth hormone receptor signaling. Trends Endocr Metab 18, 134140.CrossRefGoogle ScholarPubMed
Simmen, R C M & Kelley, A S. (2016). Reversal of fortune: estrogen receptor-beta in endometriosis. J Mol Endocr 57, F23F27.CrossRefGoogle ScholarPubMed
Southworth, M B, Matsumoto, A M, Gross, K M, Soules, M R & Bremner, W J. (1991). The importance of signal pattern in the transmission of endocrine information: pituitary gonadotropin responses to continuous and pulsatile gonadotropin-releasing hormone. J Clin Endocr Metab 72, 12861289.CrossRefGoogle ScholarPubMed
Vandewalle, J, Luypaert, A, De Bosscher, K & Libert, C. (2018). Therapeutic mechanisms of glucocorticoids. Trends Endocr Metab 29, 4254.CrossRefGoogle ScholarPubMed
Vassart, G & Costagliola, S. (2011). G protein-coupled receptors: mutations and endocrine diseases. Nat Rev Endocr 7, 362372.CrossRefGoogle ScholarPubMed
Warner, M, Huang, B & Gustafsson, J-A. (2017). Estrogen receptor β as a pharmaceutical target. Trends Pharmacol Sci 38, 9299.CrossRefGoogle ScholarPubMed
Wettschureck, N & and Offermanns, S. (2005). Mammalian G proteins and their cell type specific functions. Physiol Rev 85, 11591204.CrossRefGoogle ScholarPubMed

Send book to Kindle

To send this book to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Send book to Dropbox

To send content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about sending content to Dropbox.

Available formats
×

Send book to Google Drive

To send content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about sending content to Google Drive.

Available formats
×