Book contents
- Frontmatter
- Dedication
- Contents
- List of Contributors
- Preface
- Part I Clinical syndromes: general
- Part II Clinical syndromes: head and neck
- Part III Clinical syndromes: eye
- Part IV Clinical syndromes: skin and lymph nodes
- Part V Clinical syndromes: respiratory tract
- Part VI Clinical syndromes: heart and blood vessels
- Part VII Clinical syndromes: gastrointestinal tract, liver, and abdomen
- 43 Acute viral hepatitis
- 44 Chronic hepatitis
- 45 Biliary infection: cholecystitis and cholangitis
- 46 Pyogenic liver abscess
- 47 Infectious complications of acute pancreatitis
- 48 Esophageal infections
- 49 Gastroenteritis
- 50 Food poisoning
- 51 Antibiotic-associated diarrhea
- 52 Sexually transmitted enteric infections
- 53 Acute appendicitis
- 54 Diverticulitis
- 55 Abdominal abscess
- 56 Splenic abscess
- 57 Peritonitis
- 58 Whipple’s disease
- Part VIII Clinical syndromes: genitourinary tract
- Part IX Clinical syndromes: musculoskeletal system
- Part X Clinical syndromes: neurologic system
- Part XI The susceptible host
- Part XII HIV
- Part XIII Nosocomial infection
- Part XIV Infections related to surgery and trauma
- Part XV Prevention of infection
- Part XVI Travel and recreation
- Part XVII Bioterrorism
- Part XVIII Specific organisms: bacteria
- Part XIX Specific organisms: spirochetes
- Part XX Specific organisms: Mycoplasma and Chlamydia
- Part XXI Specific organisms: Rickettsia, Ehrlichia, and Anaplasma
- Part XXII Specific organisms: fungi
- Part XXIII Specific organisms: viruses
- Part XXIV Specific organisms: parasites
- Part XXV Antimicrobial therapy: general considerations
- Index
- References
46 - Pyogenic liver abscess
from Part VII - Clinical syndromes: gastrointestinal tract, liver, and abdomen
Published online by Cambridge University Press: 05 April 2015
- Frontmatter
- Dedication
- Contents
- List of Contributors
- Preface
- Part I Clinical syndromes: general
- Part II Clinical syndromes: head and neck
- Part III Clinical syndromes: eye
- Part IV Clinical syndromes: skin and lymph nodes
- Part V Clinical syndromes: respiratory tract
- Part VI Clinical syndromes: heart and blood vessels
- Part VII Clinical syndromes: gastrointestinal tract, liver, and abdomen
- 43 Acute viral hepatitis
- 44 Chronic hepatitis
- 45 Biliary infection: cholecystitis and cholangitis
- 46 Pyogenic liver abscess
- 47 Infectious complications of acute pancreatitis
- 48 Esophageal infections
- 49 Gastroenteritis
- 50 Food poisoning
- 51 Antibiotic-associated diarrhea
- 52 Sexually transmitted enteric infections
- 53 Acute appendicitis
- 54 Diverticulitis
- 55 Abdominal abscess
- 56 Splenic abscess
- 57 Peritonitis
- 58 Whipple’s disease
- Part VIII Clinical syndromes: genitourinary tract
- Part IX Clinical syndromes: musculoskeletal system
- Part X Clinical syndromes: neurologic system
- Part XI The susceptible host
- Part XII HIV
- Part XIII Nosocomial infection
- Part XIV Infections related to surgery and trauma
- Part XV Prevention of infection
- Part XVI Travel and recreation
- Part XVII Bioterrorism
- Part XVIII Specific organisms: bacteria
- Part XIX Specific organisms: spirochetes
- Part XX Specific organisms: Mycoplasma and Chlamydia
- Part XXI Specific organisms: Rickettsia, Ehrlichia, and Anaplasma
- Part XXII Specific organisms: fungi
- Part XXIII Specific organisms: viruses
- Part XXIV Specific organisms: parasites
- Part XXV Antimicrobial therapy: general considerations
- Index
- References
Summary
First described by Hippocrates around 400 BC, pyogenic liver abscess is an uncommon hepatic infection, but is associated with significant morbidity and healthcare costs. With the advent of imaging techniques that allow for prompt diagnosis, potent antibiotics, and effective drainage procedures, the mortality from pyogenic liver abscess has declined dramatically over the past several decades.
Epidemiology
The epidemiology of liver abscesses has changed significantly over the years. There is increasing recognition that geography plays a significant role in the demographics, etiologic factors, and clinical presentation of pyogenic liver abscesses. In the first large published series of cases of pyogenic liver abscess in the United States in 1938, there was an incidence of 8 cases per 100 000 admissions and a mortality rate of 72%. More recent US-based population studies estimate the annual incidence to be 3.6 per 100 000 population, with a higher incidence among men than women (incidence risk ratio 1.85). Significantly higher incidence rates have been reported in Taiwan at 17.6 per 100 000 population. Reported risk factors include diabetes, underlying hepatobiliary disease, and liver transplantation. In-hospital mortality ranges from 2% to 12% in developed countries and has been reported at 5.6% in the United States. Risk factors for mortality include older age; comorbidities such as cirrhosis, chronic renal failure, and malignancy; the presence of anaerobic infection; and open surgical drainage. The significant decline in associated mortality reflects changes in the underlying source of bacterial seeding and advances in diagnostic and treatment options.
- Type
- Chapter
- Information
- Clinical Infectious Disease , pp. 314 - 316Publisher: Cambridge University PressPrint publication year: 2015
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