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Chapter 11 - Sepsis

Published online by Cambridge University Press:  30 November 2019

Adam C. Adler
Affiliation:
Texas Children's Hospital
Arvind Chandrakantan
Affiliation:
Texas Children's Hospital
Ronald S. Litman
Affiliation:
The Children's Hospital of Philadelphia
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Summary

This chapter provides the reader with a succinct review on the continuum of the systemic inflammatory response syndrome through septic shock. The author provides a review on the pathophysiology of shock in children, the diagnostic criteria, and relevant monitoring considerations. The surgical procedures often required for patients with sepsis as well as the relevant anesthetic considerations are discussed.

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Chapter
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Publisher: Cambridge University Press
Print publication year: 2019

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References

Suggested Reading

Bray, RJ. Propofol infusion syndrome in children. Paediatr Anaesth. 1998;8(6):491–9 PMID: 9836214.CrossRefGoogle ScholarPubMed
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Ferreira, FL, Bota, DP, Bross, A, Mélot, C, Vincent, JL. Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA. 2001;286(14):1754–8.CrossRefGoogle ScholarPubMed
Giuliano, JS Jr, Markovitz, BP, Brierley, J, et al. Comparison of pediatric severe sepsis managed in U.S. and European ICUs. Pediatr Crit Care Med. 2016;17(6):522–30. PMID: 27124566.CrossRefGoogle ScholarPubMed
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Jones, AE, Trzeciak, S, Kline, JA. The Sequential Organ Failure Assessment score for predicting outcome in patients with severe sepsis and evidence of hypoperfusion at the time of emergency department presentation. Crit Care Med. 2009 May;37(5):1649–54. PMID: 19325482.CrossRefGoogle ScholarPubMed
Singer, M, Deutschman, CS, Seymour, CW, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801–10. PMID: 26903338.CrossRefGoogle ScholarPubMed
Vincent, JL, de Mendonça, A, Cantraine, F, et al. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on “sepsis-related problems” of the European Society of Intensive Care Medicine. Crit Care Med. 1998;26(11):1793–800. PMID: 9824069.CrossRefGoogle Scholar
Weiss, SL, Fitzgerald, JC, Pappachan, J, et al. Global epidemiology of pediatric severe sepsis: the sepsis prevalence, outcomes, and therapies study. Am J Respir Crit Care Med. 2015;191(10):1147–57. PMID: 25734408.CrossRefGoogle ScholarPubMed

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