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2.6 - Genetic Association Studies and Neurotransmitter Pathways

from 2 - Neurotransmitters and Receptors

Published online by Cambridge University Press:  08 November 2023

Mary-Ellen Lynall
Affiliation:
University of Cambridge
Peter B. Jones
Affiliation:
University of Cambridge
Stephen M. Stahl
Affiliation:
University of California, San Diego
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Summary

Over the past 50 years, genomic methodologies have paved the way to a greater understanding of the underlying pathology of mental health disorders. In that time the techniques have developed from candidate gene studies in relatively small samples of patients, to large-scale collaborative studies using array and DNA sequencing approaches. These methodological approaches are outlined in detail in Chapter 7. In particular, genome-wide association studies (GWAS), which examine the association between single-nucleotide polymorphisms (SNPs) and disease, have made great inroads into our understanding of genetic risk for mental health disorders. While SNPs can be used to investigate any part of the genome, here we focus on what they have taught us about the role of neurotransmitter systems in psychiatry.

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Chapter
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Publisher: Cambridge University Press
Print publication year: 2023

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