A long tradition of pandemic – or plague – literature, dating back at least as far as classical Greece, has used catastrophic communicable disease as a backdrop to explore the human condition: what it means to live in a community of other humans, and, as awareness of the crises of environmental devastation and climate change grows, on a planet with other living organisms. In different ways, and with differing resolutions, twentieth- and twenty-first-century works of pandemic fiction show how pandemics stem not only from human practices, but also from the values, beliefs, and stories about the past – the histories – in which they are rooted. Whether dystopic or utopic, apocalyptic or contained, literary pandemics warn that in order to change the way humans collectively inhabit the world, we need to change the dominant stories we tell about it.