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Chapter 7 - Dichotomous Outcome Variables

Published online by Cambridge University Press:  20 April 2023

Jos W. R. Twisk
Affiliation:
Amsterdam University Medical Centers
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Summary

In Chapter 7, longitudinal data analysis with a dichotomous outcome variable is discussed. The discussion includes simple methods such as the change in proportions, the McNemar test and Cochrane’s Q as well as regression-based methods such as logistic mixed model analysis and logistic GEE analysis. An important part of this chapter is related to the different results obtained from a logistic GEE analysis and a logistic mixed model analysis. The difference is caused by the fact that GEE analysis is a population average approach, while mixed model analysis is a subject-specific approach. This difference has no influence on the results of a linear mixed model or GEE analysis, but has influence on the results of a logistic mixed model or GEE analysis. It is shown that the results obtained from a logistic GEE analysis are more valid than the results obtained from a logistic mixed model analysis. Also in this chapter, all methods are accompanied by extensive real-life data examples.

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Publisher: Cambridge University Press
Print publication year: 2023

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  • Dichotomous Outcome Variables
  • Jos W. R. Twisk, Amsterdam University Medical Centers
  • Book: Applied Longitudinal Data Analysis for Medical Science
  • Online publication: 20 April 2023
  • Chapter DOI: https://doi.org/10.1017/9781009288002.008
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  • Dichotomous Outcome Variables
  • Jos W. R. Twisk, Amsterdam University Medical Centers
  • Book: Applied Longitudinal Data Analysis for Medical Science
  • Online publication: 20 April 2023
  • Chapter DOI: https://doi.org/10.1017/9781009288002.008
Available formats
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Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Dichotomous Outcome Variables
  • Jos W. R. Twisk, Amsterdam University Medical Centers
  • Book: Applied Longitudinal Data Analysis for Medical Science
  • Online publication: 20 April 2023
  • Chapter DOI: https://doi.org/10.1017/9781009288002.008
Available formats
×