4 - The Double-Jointed Fly
from Part II - Flies
Published online by Cambridge University Press: 26 February 2021
We start with an odd mutation in flies that causes their legs to be double-jointed, but what is even stranger is that the extra joints are upside-down. This leads to a discussion of cell polarity not only in flies but also in the inner ear of humans. Two intercellular signaling pathways are involved: PCP and Notch.
- Animal AnomaliesWhat Abnormal Anatomies Reveal about Normal Development, pp. 53 - 64Publisher: Cambridge University PressPrint publication year: 2021