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  • Print publication year: 2021
  • Online publication date: February 2021

4 - The Double-Jointed Fly

from Part II - Flies


We start with an odd mutation in flies that causes their legs to be double-jointed, but what is even stranger is that the extra joints are upside-down. This leads to a discussion of cell polarity not only in flies but also in the inner ear of humans. Two intercellular signaling pathways are involved: PCP and Notch.

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