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Section 6 - Public–Private Partnerships in Alzheimer’s Disease Drug Development

Published online by Cambridge University Press:  03 March 2022

Jeffrey Cummings
Affiliation:
University of Nevada, Las Vegas
Jefferson Kinney
Affiliation:
University of Nevada, Las Vegas
Howard Fillit
Affiliation:
Alzheimer’s Drug Discovery Foundation
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Summary

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Chapter
Information
Alzheimer's Disease Drug Development
Research and Development Ecosystem
, pp. 455 - 464
Publisher: Cambridge University Press
Print publication year: 2022

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References

Schneider, LS, Mangialasche, F, Andreasen, N, et al. Clinical trials and late-stage drug development for Alzheimer’s disease: an appraisal from 1984 to 2014. J Intern Med 2014; 275: 251–83.CrossRefGoogle ScholarPubMed
Petersen, RC, Doody, R, Kurz, A, et al. Current concepts in mild cognitive impairment. Arch Neurol 2001; 58: 1985–92.CrossRefGoogle ScholarPubMed
Becker, RE, Greig, NH. Alzheimer’s disease drug development in 2008 and beyond: problems and opportunities. Curr Alzheimer Res 2008; 5: 346–57.CrossRefGoogle ScholarPubMed
Cummings, JL. Integrating ADNI results into Alzheimer’s disease drug development programs. Neurobiol Aging 2010; 31: 1481–92.CrossRefGoogle ScholarPubMed
Mueller, SG, Weiner, MW, Thal, LJ, et al. The Alzheimer’s Disease Neuroimaging Initiative. Neuroimaging Clin N Am 2005; 15: 869-xii.CrossRefGoogle ScholarPubMed
Weiner, MW, Aisen, PS, Jack, CR, et al. The Alzheimer’s Disease Neuroimaging Initiative: progress report and future plans. Alzheimers Dement 2010; 6: 202–11.e7.CrossRefGoogle Scholar
Weiner, MW, Veitch, DP, Aisen, PS, et al. 2014 Update of the Alzheimer’s Disease Neuroimaging Initiative: a review of papers published since its inception. Alzheimers Dement 2015; 11: e1120.CrossRefGoogle Scholar
Weiner, MW, Veitch, DP, Aisen, PS, et al. The Alzheimer’s Disease Neuroimaging Initiative 3: continued innovation for clinical trial improvement. Alzheimers Dement 2017; 13: 561–71.Google Scholar
Lee, S, Bozeman, B. The impact of research collaboration on scientific productivity. Soc Stud Sci 2005; 35: 673702.CrossRefGoogle Scholar
Jones-Davis, DM, Buckholtz, N. The impact of ADNI: what role do public–private partnerships have in pushing the boundaries of clinical and basic science research on Alzheimer’ s disease. Alzheimers Dement 2015; 11: 860–4.CrossRefGoogle Scholar
Aisen, PS, Petersen, RC, Donohue, MC, et al. Clinical Core of the Alzheimer’s Disease Neuroimaging Initiative: progress and plans. Alzheimers Dement 2010; 6: 239–46.CrossRefGoogle Scholar
Jack, CR, Bernstein, MA, Borowski, BJ, et al. Update on the MRI core of the Alzheimer’s Disease Neuroimaging Initiative. Alzheimers Dement 2010; 6: 212–20.CrossRefGoogle Scholar
Kang, J, Korecka, M, Figurski, MJ, et al. The Alzheimer’s Disease Neuroimaging Initiative 2 Biomarker Core: a review of progress and plans. Alzheimers Dement 2015; 11: 772–91.CrossRefGoogle Scholar
Saykin, AJ, Shen, L, Yao, X, et al. Genetic studies of quantitative MCI and AD phenotypes in ADNI: progress, opportunities, and plans. Alzheimers Dement 2015; 11: 792814.CrossRefGoogle Scholar
Toga, AW, Crawford, KL. The Alzheimer’s Disease Neuroimaging Initiative Informatics Core: a decade in review. Alzheimers Dement 2015; 11: 832–9.CrossRefGoogle Scholar
Carillo, MC, Bain, LJ, Frisoni, GB, Weiner, MW. Worldwide Alzheimer’s Disease Neuroimaging Initiative. Alzheimers Dement 2012; 8: 337–42.Google Scholar
Donohue, MC, Gamst, AC, Thomas, RG, et al. The relative efficiency of time-to-threshold and rate of change in longitudinal data. Contemp Clin Trials 2011; 32: 685–93.CrossRefGoogle ScholarPubMed
Aisen, PS, Andrieu, S, Sampaio, C, et al. Report of the task force on designing clinical trials in early (predementia) AD. Neurology 2011; 76: 280–6.CrossRefGoogle ScholarPubMed
Aisen, PS, Vellas, B, Hampel, H. Moving towards early clinical trials for amyloid-targeted therapy in Alzheimer’s disease. Nat Rev Drug Discov 2013; 12: 324.CrossRefGoogle ScholarPubMed
Shaw, LM, Vanderstichele, H, Knapik-Czajka, M, et al. Cerebrospinal fluid biomarker signature in Alzheimer’s Disease Neuroimaging Initiative subjects. Ann Neurol 2009; 65: 403–13.CrossRefGoogle ScholarPubMed
Jack, CR Jr., Lowe, VJ, Weigand, SD, et al. Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer’s disease: implications for sequence of pathological events in Alzheimer’s disease. Brain 2009; 132: 1355–65.CrossRefGoogle ScholarPubMed
Veitch, DP, Weiner, MW, Aisen, PS, et al. Understanding disease progression and improving Alzheimer’s disease clinical trials: recent highlights from the Alzheimer’s Disease Neuroimaging Initiative. Alzheimers Dement 2019; 15: 106–52.CrossRefGoogle ScholarPubMed
Petersen, RC, Thomas, RG, Aisen, PS, et al. Randomized controlled trials in mild cognitive impairment: sources of variability. Neurology 2017; 88: 1751–8.CrossRefGoogle ScholarPubMed
Nelson, PT, Alafuzoff, I, Bigio, EH, et al. Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol 2012; 71: 362–8.CrossRefGoogle ScholarPubMed
Braak, H, Braak, E. Staging of Alzheimer’s disease-related neurofibrillary changes. Neurobiol Aging 1995; 16: 271–8.CrossRefGoogle ScholarPubMed
Wang, J, Logovinsky, V, Hendrix, SB, et al. ADCOMS: a composite clinical outcome for prodromal Alzheimer’s disease trials. J Neurol Neurosurg Psychiatry 2016; 87: 993–9.CrossRefGoogle ScholarPubMed
Wolz, R, Schwarz, AJ, Gray, KR, Yu, P, Hill, DL, Alzheimer’s Disease Neuroimaging Initiative. Enrichment of clinical trials in MCI due to AD using markers of amyloid and neurodegeneration. Neurology 2016; 87: 1235–41.CrossRefGoogle Scholar
Jelic, V, Kivipelto, M, Winblad, B. Clinical trials in mild cognitive impairment: lessons for the future. J Neurol Neurosurg Psychiatry 2006; 77: 429–38.CrossRefGoogle ScholarPubMed

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