The effect of CGA-362622 on annual grass control in cotton by clethodim and fluazifop-P and crop response was determined in field studies. CGA-362622 applied postemergence at 5.3 g ai/ha injured cotton up to 34% 1 wk after treatment (WAT). Injury was similar when crop oil concentrate (COC) and nonionic surfactant (NIS) were included. Adding fluazifop-P, but not clethodim, to CGA-362622 increased crop injury. Cotton recovered by 3 WAT. CGA-362622 mixed with fluazifop-P at 210 g ai/ha reduced broadleaf signalgrass and large crabgrass control 60 to 80%. Control was similar with COC or NIS in the mixture. Increasing the fluazifop-P rate to 315 g/ha did not improve control. CGA-362622 mixed with clethodim at 105 g ai/ha reduced control 65 to 80% with NIS and 40 to 65% with COC. Increasing the clethodim rate to 175 g/ha, especially with COC, substantially increased control. However, control was still less than that with clethodim at 105 g/ha. Prometryn plus MSMA postemergence-directed 3 wk after gramincide and CGA-362622 application increased control. Cotton yield was similar with clethodim alone and clethodim at 175 g/ha plus CGA-362622. Yield was reduced 29% by CGA-362622 mixed with fluazifop-P at 350 g/ha. Control was reduced by CGA-362622 applied 1 d before or after clethodim but not 5 d before or after clethodim. Control by fluazifop-P was reduced by CGA-362622 applied 1 or 5 d before or 1 d after the graminicide. Under greenhouse conditions, CGA-362622 and pyrithiobac mixed with clethodim, fluazifop-P, quizalofop-P, or sethoxydim reduced control of large crabgrass. Greater antagonism was noted with CGA-362622 than with pyrithiobac, and with fluazifop-P and quizalofop-P than with clethodim or sethoxydim.