Situated on the westernmost corner of the Southern Necropolis, Tomb S181 is an important rock-cut monument, unlike any other thus far known in Cyrene. The presence of a Doric false peristyle running all around the chamber is unique in the context of the Cyrenean funerary culture, as it seems to elaborate and modify the model of the Internal Doric Frieze (seen in famous tombs of the near-by Western Necropolis) in a new, previously unpublished solution. Tomb S181 casts further light on the complicated relationship with the Alexandrian funerary world. This paper describes the tomb and considers it from multiple and different points of view: traditional art-historical comparisons are sought in order to cast light on the chronology but, on the other hand, the display strategies are also analyzed to reconstruct the importance of this monument for the Cyrenean monumental funerary tradition. Tomb S181 is certainly a hybrid entity, the product of a local culture accepting but also deeply modifying Alexandrian influences in terms of architecture and, possibly, also of funerary ritual behaviours. Tomb S181 clearly attests the vitality of rock-cut funerary architecture in Cyrene during the Hellenistic period.