Field experiments were conducted in 2015 and 2016 to study the effect of tillage frequency, seed rate, and glyphosate on teff and weeds. The experiments were arranged in a split plot design with three replications consisting of tillage frequency (conventional, minimum, and zero tillage) as the main plot and the combination of seed rate (5, 15, and 25 kg ha−1) and glyphosate (with and without) as subplots. Results showed that zero tillage reduced teff biomass yield by 15% compared to minimum tillage and by 26% compared to conventional tillage. Zero tillage and minimum tillage also diminished grain yield by 21% and 13%, respectively, compared to conventional tillage. Lowering the seed rate to 5 kg ha−1 reduced biomass yield by 22% and 26% compared to 15 and 25 kg ha−1, respectively. It also reduced the grain yield by around 21% compared to 15 and 25 kg ha−1 seed rates. Conventional tillage significantly diminished weed density, dry weight, and cover by 19%, 29%, and 33%, respectively, compared to zero tillage. The highest seed rate significantly reduced total weed density, dry weight, and cover by 18%, 19%, and 15%, respectively, compared to the lowest seed rate. Glyphosate did not affect weed density but reduced weed dry weight by 14% and cover by 15%. Generally, sowing teff using minimum tillage combined with glyphosate application and seed rate of 15 kg ha−1 enhanced its productivity and minimized weed effects.