Diclosulam is generally applied either PPI or PRE to peanut to control certain broadleaf weeds and suppress sedges. Research was conducted to determine efficacy and peanut response to POST applications of diclosulam at 9, 13, 18, and 27 g ai/ha. Efficacy of diclosulam was affected by application rate and environment. Common ragweed control ranged from 60 to 100%, entireleaf morningglory control from 56 to 100%, marestail control from 78 to 85%, and nodding spurge from 50 to 97%. Smooth pigweed and common lambsquarters were both controlled less than 35%. Diclosulam controlled yellow nutsedge and eclipta less than 70 and 80%, respectively. In separate experiments, diclosulam and imazapic controlled dogfennel more effectively than acifluorfen, bentazon, imazethapyr, lactofen, paraquat, or 2,4-DB. Visual estimates of peanut injury were 15% or less for all rates during both years. Peanut yield ranged from 3,340 to 3,730 kg/ha in 2002 and 5,230 to 5,820 kg/ha in 2003. Foliar injury and peanut pod yield were influenced by diclosulam rate, although no clear relation was evident. Cultivar and diclosulam rate did not interact with respect to visual injury or pod yield.