Field studies conducted at three locations in North Carolina in 1998 and 1999 evaluated crop tolerance, weed control, and yield with CGA-362622 alone and in combination with various weed management systems in transgenic and nontransgenic cotton systems. The herbicide systems used bromoxynil, CGA-362622, glyphosate, and pyrithiobac applied alone early postemergence (EPOST) or mixtures of CGA-362622 plus bromoxynil, glyphosate, or pyrithiobac applied EPOST. Trifluralin preplant incorporated followed by (fb) fluometuron preemergence (PRE) alone or fb a late POST–directed (LAYBY) treatment of prometryn plus MSMA controlled all the weed species present less than 90%. Herbicide systems that included soil-applied and LAYBY herbicides plus glyphosate EPOST or mixtures of CGA-362622 EPOST plus bromoxynil, glyphosate, or pyrithiobac controlled broadleaf signalgrass, entireleaf morningglory, large crabgrass, Palmer amaranth, prickly sida, sicklepod, and smooth pigweed at least 90%. Only cotton treated with these herbicide systems yielded equivalent to the weed-free check for each cultivar. Bromoxynil systems did not control Palmer amaranth and sicklepod, pyrithiobac systems did not control sicklepod, and CGA-362622 systems did not control prickly sida.