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Emotion dysregulation is a risk factor for the development of a variety of psychopathologic outcomes. In children, irritability, or dysregulated negative affect, has been the primary focus, as it predicts later negative outcomes even in very young children. However, dysregulation of positive emotion is increasingly recognized as a contributor to psychopathology. Here we used an exploratory factor analysis and defined four factors of emotion dysregulation: irritability, excitability, sadness, and anhedonia, in the preschool-age psychiatric assessment collected in a sample of 302 children ages 3–5 years enriched for early onset depression. The irritability and excitability factor scores defined in preschoolers predicted later diagnosis of mood and externalizing disorders when controlling for other factor scores, social adversity, maternal history of mood disorders, and externalizing diagnoses at baseline. The preschool excitability factor score predicted emotion lability in late childhood and early adolescence when controlling for other factor scores, social adversity, and maternal history. Both excitability and irritability factor scores in preschoolers predicted global functioning into the teen years and early adolescence, respectively. These findings underscore the importance of positive, as well as negative, affect dysregulation as early as the preschool years in predicting later psychopathology, which deserves both further study and clinical consideration.
We present a workflow to track icebergs in proglacial fjords using oblique time-lapse photos and the Lucas-Kanade optical flow algorithm. We employ the workflow at LeConte Bay, Alaska, where we ran five time-lapse cameras between April 2016 and September 2017, capturing more than 400 000 photos at frame rates of 0.5–4.0 min−1. Hourly to daily average velocity fields in map coordinates illustrate dynamic currents in the bay, with dominant downfjord velocities (exceeding 0.5 m s−1 intermittently) and several eddies. Comparisons with simultaneous Acoustic Doppler Current Profiler (ADCP) measurements yield best agreement for the uppermost ADCP levels (~ 12 m and above), in line with prevalent small icebergs that trace near-surface currents. Tracking results from multiple cameras compare favorably, although cameras with lower frame rates (0.5 min−1) tend to underestimate high flow speeds. Tests to determine requisite temporal and spatial image resolution confirm the importance of high image frame rates, while spatial resolution is of secondary importance. Application of our procedure to other fjords will be successful if iceberg concentrations are high enough and if the camera frame rates are sufficiently rapid (at least 1 min−1 for conditions similar to LeConte Bay).
High unemployment is a hallmark of psychotic illness. Individual placement and support (IPS) may be effective at assisting the vocational recoveries of young people with first-episode psychosis (FEP).
To examine the effectiveness of IPS at assisting young people with FEP to gain employment (Australian and Clinical Trials Registry ACTRN12608000094370).
Young people with FEP (n = 146) who were interested in vocational recovery were randomised using computer-generated random permuted blocks on a 1:1 ratio to: (a) 6 months of IPS in addition to treatment as usual (TAU) or (b) TAU alone. Assessments were conducted at baseline, 6 months (end of intervention), 12 months and 18 months post-baseline by research assistants who were masked to the treatment allocations.
At the end of the intervention the IPS group had a significantly higher rate of having been employed (71.2%) than the TAU group (48.0%), odds ratio 3.40 (95% CI 1.17–9.91, z = 2.25, P = 0.025). However, this difference was not seen at 12- and 18-month follow-up points. There was no difference at any time point on educational outcomes.
This is the largest trial to our knowledge on the effectiveness of IPS in FEP. The IPS group achieved a very high employment rate during the 6 months of the intervention. However, the advantage of IPS was not maintained in the long term. This seems to be related more to an unusually high rate of employment being achieved in the control group rather than a gross reduction in employment among the IPS group.
We study the shape and motion of gas bubbles in a liquid flowing through a horizontal or slightly inclined thin annulus. Experimental data show that in the horizontal annulus, bubbles develop a unique ‘tadpole-like’ shape with a semi-circular cap and a highly stretched tail. As the annulus is inclined, the bubble tail tends to vanish, resulting in a significant decrease of bubble length. To model the bubble evolution, the thin annulus is conceptualised as a ‘Hele-Shaw’ cell in a curvilinear space. The three-dimensional flow within the cell is represented by a gap-averaged, two-dimensional model, which achieved a close match to the experimental data. The numerical model is further used to investigate the effects of gap thickness and pipe diameter on the bubble behaviour. The mechanism for the semi-circular cap formation is interpreted based on an analogous irrotational flow field around a circular cylinder, based on which a theoretical solution to the bubble velocity is derived. The bubble motion and cap geometry is mainly controlled by the gravitational component perpendicular to the flow direction. The bubble elongation in the horizontal annulus is caused by the buoyancy that moves the bubble to the top of the annulus. However, as the annulus is inclined, the gravitational component parallel to the flow direction becomes important, causing bubble separation at the tail and reduction in bubble length.
Measurements in the infrared wavelength domain allow direct assessment of the physical state and energy balance of cool matter in space, enabling the detailed study of the processes that govern the formation and evolution of stars and planetary systems in galaxies over cosmic time. Previous infrared missions revealed a great deal about the obscured Universe, but were hampered by limited sensitivity.
SPICA takes the next step in infrared observational capability by combining a large 2.5-meter diameter telescope, cooled to below 8 K, with instruments employing ultra-sensitive detectors. A combination of passive cooling and mechanical coolers will be used to cool both the telescope and the instruments. With mechanical coolers the mission lifetime is not limited by the supply of cryogen. With the combination of low telescope background and instruments with state-of-the-art detectors SPICA provides a huge advance on the capabilities of previous missions.
SPICA instruments offer spectral resolving power ranging from R ~50 through 11 000 in the 17–230 μm domain and R ~28.000 spectroscopy between 12 and 18 μm. SPICA will provide efficient 30–37 μm broad band mapping, and small field spectroscopic and polarimetric imaging at 100, 200 and 350 μm. SPICA will provide infrared spectroscopy with an unprecedented sensitivity of ~5 × 10−20 W m−2 (5σ/1 h)—over two orders of magnitude improvement over what earlier missions. This exceptional performance leap, will open entirely new domains in infrared astronomy; galaxy evolution and metal production over cosmic time, dust formation and evolution from very early epochs onwards, the formation history of planetary systems.
We assessed various locations and frequency of environmental sampling to maximize information and maintain efficiency when sampling for Acinetobacter baumannii. Although sampling sites in closer proximity to the patient were more likely positive, to fully capture environmental contamination, we found value in sampling all sites and across multiple days.
Nutraceuticals have generated interest as a way to mitigate the cognitive decline in older adults. The aim of this systematic review was to determine the evidence for these claims from the scientific literature in randomised, double-blinded, controlled trials (duration: ≥1 year; participants: n≥100; age(mean): ≥65 years). Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched four electronic databases (PubMed, Scopus, CINAHL and Web of Science) and identified twenty-five studies published between the 15·June·2006 and 14·June·2016. Interventions included B-vitamins, n-3 fatty acids, antioxidant vitamins and herbs. Of the B-vitamin studies, four found benefits to cognition with supplementation. The first of these B-vitamin studies, in individuals with mild cognitive impairment (n 266; duration=2 years), included benefit to executive function (P=0·015) and improvements in the Mini-Mental State Examination (MMSE) among participants with baseline homocysteine above 11·3 µmol/l (P<0·001). In the same sample, the second study found cognitive benefits of B-vitamins dependent on the higher baseline plasma n-3 fatty acid status. The third B-vitamin study (n 900; duration=2 years) reported improved performance in immediate (P=0·046) and delayed recall (P=0·013), whereas the fourth study (n 856; duration=2 years) reported slower rate of cognitive decline in the MMSE (P=0·05). One study investigating DHA treatment (n 402; duration=1·5 years) revealed the slower rate of cognitive change in apoE e4 non-carriers (P=0·03). As only five included studies revealed notable benefits, presently based on the specific compounds explored here, there is not compelling evidence to support the use nutraceuticals to improve cognition in the elderly. Future long-term trials of nutraceuticals should investigate interactions with lifestyle, blood biomarkers and genetic risk factors.
Previous work has shown that processing whole crop wheat (WCW) at harvest increases starch digestibility (Jackson et al., 2002). However, no effect was seen in terms of milk yield. It has been suggested that the provision of a sugar source might utilise the high rumen ammonia levels found in animals receiving urea-treated whole crop wheat (Abdalla et al., 1999). Sources such as lactose have also been shown to reduce rumen protozoa numbers, increase bacterial protein supply and result in a more stable rumen pH, particularly with high starch diets (Hussain and Miller, 1999). Additionally, to date, processed whole crop wheat has not been evaluated against other alternative forages. The objective of the current experiment was, therefore, to compare processed urea treated whole crop wheat with maize silage and determine the effects of carbohydrate supplementation of whole crop wheat on intake and milk production in dairy cows.
It has been suggested that periparturient breakdown of immunity to parasites (BIP) has a nutritional basis (Coop and Kyriazakis, 1999). In support of this hypothesis, recent studies have shown that an increased supply of metabolizable protein (MP) reduces the magnitude of periparturient BIP in sheep (Houdijk et al., 2001). Improved MP supply to ewes, infected with gastrointestinal nematodes, has been associated with reduced nematode egg excretion and smaller worm burdens. These immunity indicators may differ in their sensitivity to changes in MP supply. This hypothesis has been addressed in the current doses-response experiment, which also allowed us to estimate the MP requirements of parasitized, lactating, twin-rearing ewes. The latter can be expected to be larger than those of non-parasitized ewes, due to MP requirements for mounting an immune response and for replenishing protein losses.
Gastrointestinal (GI) parasites, acquired by sheep through the action of foraging, are the most pervasive challenge to their survival and reproduction. The eggs of many GI parasite species are deposited on pasture in faeces where they develop into infective stage larvae that contaminate surrounding swards. We test the hypotheses that (1) faeces and hence parasite avoidance behaviour of sheep creates a grazing trade-off between nutrition and parasitism and (2) the relative costs and benefits of the trade-off in relation to animal state of infection (parasitized, non-parasitized, immune) determines their subsequent grazing behaviour.
To examine dietary Na and K intake at eating occasions in Australian adults and identify the contribution of major food sources to Na and K at different eating occasions.
Secondary analysis of 24 h recall diet data from the Australian Health Survey (2011–2013).
Nationally representative survey in Australia.
Male and female Australians aged 18–84 years (n 7818).
Dinner contributed the greatest proportion to total daily Na intake (33 %) and K intake (35 %). Na density was highest at lunch (380 mg/MJ) and K density highest at between-meal time eating occasions (401 mg/MJ). Between-meal time eating occasions provided 20 % of daily Na intake and 26 % of daily K intake. The major food group sources of Na were different at meal times (breads and mixed dishes) compared with between-meal times (cakes, muffins, scones, cake-type desserts). The top food group sources of K at meal times were potatoes and unprocessed meat products and dishes.
Foods which contributed to Na and K intake differed according to eating occasion. Major food sources of Na were bread and processed foods. Major food sources of K were potatoes and meat products and dishes. Public health messages that emphasise meal-based advice and diet patterns high in vegetables, fruits and unprocessed foods may also aid reduction in dietary Na intake and increase in dietary K intake.
To avoid some of the limitations of studying soft-bed processes through boreholes, a prism of simulated till (1.8 m × 1.6 m × 0.45 m) with extensive instrumentation was constructed in a trough blasted in the rock bed of Engabreen, a temperate glacier in Norway. Tunnels there provide access to the bed beneath 213 m of ice. Pore-water pressure was regulated in the prism by pumping water to it. During experiments lasting 7–12 days, the glacier regelated downward into the prism to depths of 50–80 mm, accreting ice-infiltrated till at rates predicted by theory. During periods of sustained high pore-water pressure (70–100% of overburden), ice commonly slipped over the prism, due to a water layer at the prism surface. Deformation of the prism was activated when this layer thinned to a sub-millimeter thickness. Shear strain in the till was pervasive and decreased with depth. A model of slip by ploughing of ice-infiltrated till across the prism surface accounts for the slip that occurred when effective pressure was sufficiently low or high. Slip at low effective pressures resulted from water-layer thickening that increased non-linearly with decreasing effective pressure. If sufficiently widespread, such slip over soft glacier beds, which involves no viscous deformation resistance, may instigate abrupt increases in glacier velocity.
We report on observations of Cen A using the SEST telescope (Swedish-ESO Submillimeter Telescope). In a previous paper (Eckart et al. 1990a, hereafter Paper I) we presented a fully sampled map of the 12CO(1-0) distribution in the disk which complements the 12CO(2-1) cuts obtained by Phillips et al. (1987, 1989). From these data we determined that the ISM in the disk of Centaurus A is cold (T<10 K), with densities of the order of the 12CO critical density (∼2 × 104 cm—3). Absorption against the nuclear continuum source has been reported for HI (van Gorkom 1987, van der Hulst et al. 1983, Whiteoak and Gardner 1971) and a number of molecular species, such as OH, H2CO, C3H2, 12CO, and 13CO (Whiteoak and Gardner 1971, Gardner and Whiteoak 1976, Bell and Seaquist 1988, Phillips et al. 1987, Israel et al. 1990). Here we summarize measurements of absorption in the lines of 12CO, 13CO, HCO+, HCN, CN and CS (see Eckart et al. 1990b; hereafter Paper II).
Whole apples have not been previously implicated in outbreaks of foodborne bacterial illness. We investigated a nationwide listeriosis outbreak associated with caramel apples. We defined an outbreak-associated case as an infection with one or both of two outbreak strains of Listeria monocytogenes highly related by whole-genome multilocus sequence typing (wgMLST) from 1 October 2014 to 1 February 2015. Single-interviewer open-ended interviews identified the source. Outbreak-associated cases were compared with non-outbreak-associated cases and traceback and environmental investigations were performed. We identified 35 outbreak-associated cases in 12 states; 34 (97%) were hospitalized and seven (20%) died. Outbreak-associated ill persons were more likely to have eaten commercially produced, prepackaged caramel apples (odds ratio 326·7, 95% confidence interval 32·2–3314). Environmental samples from the grower's packing facility and distribution-chain whole apples yielded isolates highly related to outbreak isolates by wgMLST. This outbreak highlights the importance of minimizing produce contamination with L. monocytogenes. Investigators should perform single-interviewer open-ended interviews when a food is not readily identified.
To examine self-reported practices and policies to reduce infection and transmission of multidrug-resistant organisms (MDRO) in healthcare settings outside the United States.
International members of the Society for Healthcare Epidemiology of America (SHEA) Research Network.
Electronic survey of infection control and prevention practices, capabilities, and barriers outside the United States and Canada. Participants were stratified according to their country’s economic development status as defined by the World Bank as low-income, lower-middle-income, upper-middle-income, and high-income.
A total of 76 respondents (33%) of 229 SHEA members outside the United States and Canada completed the survey questionnaire, representing 30 countries. Forty (53%) were high-, 33 (43%) were middle-, and 1 (1%) was a low-income country. Country data were missing for 2 respondents (3%). Of the 76 respondents, 64 (84%) reported having a formal or informal antibiotic stewardship program at their institution. High-income countries were more likely than middle-income countries to have existing MDRO policies (39/64 [61%] vs 25/64 [39%], P=.003) and to place patients with MDRO in contact precautions (40/72 [56%] vs 31/72 [44%], P=.05). Major barriers to preventing MDRO transmission included constrained resources (infrastructure, supplies, and trained staff) and challenges in changing provider behavior.
In this survey, a substantial proportion of institutions reported encountering barriers to implementing key MDRO prevention strategies. Interventions to address capacity building internationally are urgently needed. Data on the infection prevention practices of low income countries are needed.
Late-life depression (LLD) is associated with a decline in physical activity. Typically this is assessed by self-report questionnaires and, more recently, with actigraphy. We sought to explore the utility of a bespoke activity monitor to characterize activity profiles in LLD more precisely.
The activity monitor was worn for 7 days by 29 adults with LLD and 30 healthy controls. Subjects underwent neuropsychological assessment and quality of life (QoL) (36-item Short-Form Health Survey) and activities of daily living (ADL) scales (Instrumental Activities of Daily Living Scale) were administered.
Physical activity was significantly reduced in LLD compared with controls (t = 3.63, p < 0.001), primarily in the morning. LLD subjects showed slower fine motor movements (t = 3.49, p < 0.001). In LLD patients, activity reductions were related to reduced ADL (r = 0.61, p < 0.001), lower QoL (r = 0.65, p < 0.001), associative learning (r = 0.40, p = 0.036), and higher Montgomery–Åsberg Depression Rating Scale score (r = −0.37, p < 0.05).
Patients with LLD had a significant reduction in general physical activity compared with healthy controls. Assessment of specific activity parameters further revealed the correlates of impairments associated with LLD. Our study suggests that novel wearable technology has the potential to provide an objective way of monitoring real-world function.
VLA observations in the (J, K)=(3,3) line of ammonia reveal new structures in the Galactic center region. An approximate ring of emission is centered on the central ionized streamers. This ring, seen previously in millimeter-wave interferometer maps, is very clumpy in the ammonia emission, with size scales ≲10″ (0.4 pc). The clumps show good spatial and velocity agreement with the ionized gas, and are warm with brightness temperatures exceeding 30 K. A comparison of the (3,3) to (1,1) ratio indicates considerably higher gas temperatures. This circumnuclear ring may not be the dominant feature in the mass distribution of the circumnuclear gas. A streamer, immediately to the south of the Galactic center, connects the gas complex at lII= −4′ (~10 pc) directly to the Galactic center. This streamer may define the path for gas flow into the nuclear region.
We report VLA observations of H76α emission from the H II region in M–0.13–0.08, the Sgr A “15 km s−1 cloud.” The line to continuum flux ratio implies an electron temperature Te ~ 7500 K, slightly lower than measurements of Te in Sgr B2. The deduced number of early stars and the infrared luminosity are consistent with a normal IMF in this cloud.
We describe the performance of the Boolardy Engineering Test Array, the prototype for the Australian Square Kilometre Array Pathfinder telescope. Boolardy Engineering Test Array is the first aperture synthesis radio telescope to use phased array feed technology, giving it the ability to electronically form up to nine dual-polarisation beams. We report the methods developed for forming and measuring the beams, and the adaptations that have been made to the traditional calibration and imaging procedures in order to allow BETA to function as a multi-beam aperture synthesis telescope. We describe the commissioning of the instrument and present details of Boolardy Engineering Test Array’s performance: sensitivity, beam characteristics, polarimetric properties, and image quality. We summarise the astronomical science that it has produced and draw lessons from operating Boolardy Engineering Test Array that will be relevant to the commissioning and operation of the final Australian Square Kilometre Array Path telescope.
A major international effort to observe and compile the results of observations from many transit circle programs into a single catalog of positions referred to the FK4 system came to a conclusion with the completion and distribution of the Southern Reference Star (SRS) catalog of 20,488 stars. Previous discussions focussed on the adjustments to the observational material to refer it to the FK4 system and on the random errors as estimated from residual differences. In the present discussion, we give the results of internal comparisons which have been made between the individual contributing catalogs and the final combined SRS catalog. Also, results of a comparison between the SRS catalog and the AGK3R catalog are given where they overlap in the declination zone from +5 to −5 degrees. The possibility of magnitude equation and color error in the SRS catalog is discussed.
The reduction procedure used to transform the version of the SRS catalog based on the FK4/B1950.0 system to the version based on the FK5/J2000.0 system is given.