One of the goals of the Vrokastro Survey Project, based in west-central Mirabello, eastern Crete, was to identify a site within the boundaries of the survey study area worthy of further investigation, including excavation. The settlement selected, based on its complexity and long lifespan, was Priniatikos Pyrgos, a harbour community and ‘gateway’ of the Vrokastro region. As a preliminary to excavation, the Istron Geoarchaeological Project was initiated in order to document the nature, condition, and resources of this site and its coastal environment. This multidisciplinary program was implemented through fieldwork, laboratory analyses, and geophysical prospection. Results include new data concerning the industrial aspects of Priniatikos Pyrgos, the changing topographical situation of the site and coastal zone, the overall size of this diachronic harbor settlement, and the regional resources involved in ceramic and metallurgical production.