Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
  1. Home
  2. Search

Refine search

Refine search

Access:
Content type:
Publication date:
Apply   From and To filters
Subject: Show more
Journals Show more
Publishers: Show more
Societies Show more
Series: Show more
Collections: Show more

Actions for selected content:

Select all | Deselect all
  • View selected items
  • Export citations
  • Download PDF (zip)
  • Save to Kindle
  • Save to Dropbox
  • Save to Google Drive

Save Search

You can save your searches here and later view and run them again in "My saved searches".

Please provide a title, maximum of 40 characters.
Cancel
×

26 results

Page 1 of 2

  • Chapter 25 - Sperm Selection in the Laboratory

  • from Section 4 - Laboratory Evaluation and Treatment of Male Infertility
  • Edited by Douglas T. Carrell, Utah Center for Reproductive Medicine, Alexander W. Pastuszak, University of Utah, James M. Hotaling, Utah Center for Reproductive Medicine
  • Book:
    Men's Reproductive and Sexual Health Throughout the Lifespan
    Published online:
    06 December 2023
    Print publication:
    16 November 2023, pp 197-203

  • Summary

    In nature varying strategies are used to ensure that the best sperm arrives at the egg. Strategies to select the best sperm are far less rigorous in the setting of in vitro fertilization. In this chapter we discuss how in vitro sperm selection strategies utilize different components of the spermatozoon including their motility characteristics, size, membrane properties, and nuclear structure. Sperm selection strategies have included microfluidics, spectroscopy, label-free imaging, hyaluronan binding, and separation of sperm by charge. Although some studies have shown that sperm selection can improve embryo euploidy rates and pregnancy outcomes, in particular by reducing miscarriages, large clinical trials, focused on the male population who would benefit most from sperm selection, are still needed.

Patient-Centered Assisted Reproduction
  • How to Integrate Exceptional Care with Cutting-Edge Technology
  • Edited by Alice D. Domar, Denny Sakkas, Thomas L. Toth
  • Published online:
    02 March 2020
    Print publication:
    19 March 2020
  • Address the future of innovative reproductive technologies with experts in the fields of IVF, fertility preservation and laboratory advances. This essential resource examines the changing roles of IVF, and moves beyond the basics of reproductive medicine. This book introduces the optimization of care, to improve patient outcomes, whilst facing ethical challenges that accompany new technologies, and applying the patient-centered care model to improve both patient and staff retention. By showcasing the future of the field in terms of clinical practice and innovative laboratory technologies, this guide will support clinics worldwide to provide high-quality customer experience, maintaining a competitive edge, following increasing standardization of clinical and laboratory protocols. This invaluable guide features chapters on patient evaluation, predictive modelling, advances in pharmacology, and laboratories of the future. Written by research and clinical leaders from around the world, it describes ground-breaking innovative treatments and technologies, encompassing the care model in a holistic way.

  • Chapter 27 - Metabolomics

  • from Section 5 - Laboratory
  • Edited by Gab Kovacs, Monash University, Victoria
  • Book:
    How to Improve your ART Success Rates
    Published online:
    05 July 2011
    Print publication:
    30 June 2011, pp 147-151

  • Summary

    The inherent ease of laboratory assessment of various morphological markers makes it the preferred assessment technique of embryo transfer. Even with the adoption of more complex forms of assessment it remains as one of the main tools available for embryo selection. For a new assessment procedure to be acceptable in an in vitro fertilization (IVF) laboratory setting it must satisfy a number of criteria. The complete array of small-molecule metabolites that are found within a biological system constitutes the metabolome, which can be considered to reflect the functional phenotype. Using various forms of spectral and analytical approaches, metabolomics attempts to determine metabolites associated with physiologic and pathologic states. Investigation of the metabolome of embryos, by analysis of the culture media they grow in, using targeted spectroscopic analysis and bioinformatics, will plausibly assist in identifying the most viable embryo(s) within a cohort.

  • Chapter 25 - Day of embryo transfer

  • from Section 5 - Laboratory
  • Edited by Gab Kovacs, Monash University, Victoria
  • Book:
    How to Improve your ART Success Rates
    Published online:
    05 July 2011
    Print publication:
    30 June 2011, pp 139-142

  • Summary

    This chapter provides data to identify which day(s) of development the human embryo should be replaced in the uterus. By transferring the embryo post-compaction at the blastocyst stage, one not only synchronizes embryo development with the female reproductive tract, but also places the embryo in the uterus at a time when there are greatly reduced uterine contractions, thereby negating the possibility of the embryo being expelled. The first prospective randomized trial comparing human embryo transfer on either day 3 or day 5 in good prognosis patients revealed a significantly higher implantation and pregnancy rate when transfer occurred at the blastocyst stage. With the recent improvements in the in vitro fertilization (IVF) laboratory, combined with patient stimulation regimens designed to generate fewer, healthier oocytes, single embryo transfer (SET) is now a feasible patient treatment. The move to SET is especially relevant to good prognosis patients and oocyte donation programs.

  • Chapter 20 - Sperm diagnosis:

  • Edited by David K. Gardner, University of Melbourne, Botros R. M. B. Rizk, University of South Alabama, Tommaso Falcone
  • Book:
    Human Assisted Reproductive Technology
    Published online:
    16 May 2011
    Print publication:
    31 March 2011, pp 223-231

  • Summary

    Several medications have been found to increase implantation rates with in vitro fertilization (IVF) when given as adjuncts to follicle stimulating hormone (FSH) stimulation of the ovaries in preparation for oocyte retrieval. Gonadotropin-releasing hormone (GnRH) agonists, oral contraceptives (OCs), and estrogen pretreatment help to synchronize the follicular cohort resulting in an improved ovarian response. Metformin (MET) increases implantation in PCOS women having IVF and dramatically reduces the incidence of ovarian hyperstimulation syndrome (OHSS) in these women. Growth hormone (GH) markedly increases implantation in poor-responding women having IVF. Small doses of human chorionic gonadotropin (hCG) are used to provide LH activity allowing use of pure FSH products and the pen devices that deliver graduated FSH doses. Low-dose aspirin (ASA) increases ovarian response and implantation, and reduces the incidence of severe OHSS. Drugs such as letrozole that increase androgens may prove to be useful agents to increase ovarian response in poor responders.

Page 1 of 2