Center and periphery are popular concepts to describe geographical, political, or economic power relations. Both are mostly perceived as strict and mutually exclusive categories. This article examines a Galician border town whose history illustrates the complexities of conceptualizing center and periphery relations. At first glance, nineteenth-century Brody (in today's Ukraine) would seem to qualify as a peripheral town located on the Galician border between the Austro-Hungarian and Russian Empires. An analysis of this city under Habsburg rule (1772–1918), however, shows us that during that period it constituted both an important center and a declining periphery, not only consecutively, but also simultaneously. Its situation on the country's physical and political periphery did not harm Brody's central role in Europe's East-West trade until the first twenty years of the nineteenth century. Only in later decades did the city lose its place within a modernizing commercial system, and eventually it declined in importance. If we leave aside the economic aspect and take a closer look at Brody's mostly Jewish inhabitants, we see that for centuries this city functioned as an important center for Eastern and Central European Jewry. Even though the town's centrality for Jewish history also changed over time, Brody nevertheless kept its place on Jewish mental maps, whether as a center of religious learning, as a pioneering site of political emancipation, or as a safe haven for Jewish refugees.