Hostname: page-component-8448b6f56d-gtxcr Total loading time: 0 Render date: 2024-04-20T03:06:50.067Z Has data issue: false hasContentIssue false
  • English
  • Français

Winner takes it all: Addiction as an example for selfish goal dominance

Published online by Cambridge University Press:  29 April 2014

Christian P. Müller  and
Davide Amato
Christian P. Müller
Affiliation:
Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University Erlangen-Nuremberg, 91054 Erlangen, Germany. christian.mueller@uk-erlangen.dedavide.amato@uk-erlangen.dehttp://www.psychiatrie.uk-erlangen.de/wir_ueber_uns/mitarbeiter/prof_dr_rer_nat_christian_p_mueller/index_ger.html
Davide Amato
Affiliation:
Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University Erlangen-Nuremberg, 91054 Erlangen, Germany. christian.mueller@uk-erlangen.dedavide.amato@uk-erlangen.dehttp://www.psychiatrie.uk-erlangen.de/wir_ueber_uns/mitarbeiter/prof_dr_rer_nat_christian_p_mueller/index_ger.html
Get access Rights & Permissions [Opens in a new window]

Abstract

Here we argue that the selfish goal concept may well be suitable to explain inconsistencies not only in micro-behaviors, but also in the gross behavioral repertoire of an individual, which is often associated with psychopathologies, such as addiction. Neurophysiological evidence for pathological conditions like addiction emerged, and this evidence may also serve as an explanatory model for normal behaviors.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 37 , Issue 2 , April 2014 , pp. 152
Copyright
Copyright © Cambridge University Press 2014 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

American Psychiatric Association (1994) Diagnostic statistical manual of mental disorders, 4th ed. (DSM-IV). American Psychiatric Association.Google Scholar
Belin, D. & Everitt, B. J. (2008) Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum. Neuron 57(3):432–41.Google Scholar
Belin, D., Jonkman, S., Dickinson, A., Robbins, T. W. & Everitt, B. J. (2009) Parallel and interactive learning processes within the basal ganglia: Relevance for the understanding of addiction. Behavioural Brain Research 199:89–102.Google Scholar
Dawkins, R. (1976) The selfish gene. Oxford University Press.Google Scholar
Haber, S. N., Fudge, J. L. & McFarland, N. R. (2000) Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum. Journal of Neuroscience 20(6):2369–82.Google Scholar
Knowlton, B. J., Mangels, J. A. & Squire, L. R. (1996) A neostriatal habit learning system in humans. Science 273:1399–402.Google Scholar
Kolb, B., Gorny, G., Li, Y. L., Samaha, A. N. & Robinson, T. E. (2003) Amphetamine or cocaine limits the ability of later experience to promote structural plasticity in the neocortex and nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America 100:10523–28.Google Scholar
Müller, C. P. (2013) Episodic memories and their relevance for psychoactive drug use and addiction. Frontiers in Behavioral Neuroscience 7(34):1–13.CrossRefGoogle ScholarPubMed
Müller, C. P., Pum, M. E., Schumann, G. & Huston, J. P. (2010) The role of serotonin in drug addiction. In: The behavioral neurobiology of serotonin, ed. Müller, C. P. & Jacobs, B. L., pp. 507–46. Academic Press.CrossRefGoogle Scholar
Müller, C. P. & Schumann, G. (2011) Drugs as instruments: A new framework for non-addictive psychoactive drug use. Behavioural Brain Research 34 (6):293–347.Google Scholar
Pelloux, Y., Dilleen, R., Economidou, D., Theobald, D. & Everitt, B. J. (2012) Reduced forebrain serotonin transmission is causally involved in the development of compulsive cocaine seeking in rats. Neuropsychopharmcology 37:2505–14.Google Scholar
Robbins, T. W., Ersche, K. D. & Everitt, B. J. (2008) Drug addiction and the memory systems of the brain. Annals of the New York Academy of Sciences 1141:1–21.Google Scholar
Robinson, T. E. & Kolb, B. (2004) Structural plasticity associated with exposure to drugs of abuse. Neuropharmacology 47:33–46.Google Scholar
Saal, D., Dong, Y., Bonci, A. & Malenka, R. C. (2003) Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons. Neuron 37:577–82.CrossRefGoogle ScholarPubMed
Ungless, M. A., Whistler, J. L., Malenka, R. C. & Bonci, A. (2001) Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons. Nature 411:583–87.Google Scholar
White, N. M. (1996) Addictive drugs as reinforcers: Multiple partial actions on memory systems. Addiction 91:921–49.Google Scholar