Field-studies were conducted over two years to determine the area of influence and duration of interference of wild poinsettia in soybean. Soybean canopy width averaged across years was reduced approximately 10% beginning at 6 wk of interference for both the 0- to 10-and 10-to 20-cm distances from the weed. Soybean dry weights decreased from 14 to 38% within 20 cm of the weed for 12 through 18 wk of interference. In 1990, soybean yield within 10 cm of wild poinsettia was similar to distances of 10 to 20 and 20 to 40 cm, but was less than that for distances greater than 40 cm from the weed. Weed interference resulted in a 9.5% yield reduction in the 0- to 10-cm distance when compared with the 80-to 100-cm distance. In contrast, yield of soybean in 1991 growing within 10 cm of the weed was less than at greater distances, corresponding to an 18% yield reduction when compared with 80 to 100 cm. Differences in wild poinsettia dry weights when growing alone and when growing within the soybean row occurred after 6 and 8 wk of interference in 1990 and 1991, respectively. In 1991 when rainfall during the growing season was twice that of the previous year, canopy width and dry weight of wild poinsettia growing within the soybean row were reduced an average of 57 and 82%, respectively, compared with weeds growing alone.