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The Utility of a Single-Point Dosing Protocol for Predicting Steady-State Lithium Levels

Published online by Cambridge University Press:  29 January 2018

Paul J. Perry ,
Bruce Alexander ,
Randall A. Prince  and
Frederick J. Dunner
Paul J. Perry*
Affiliation:
University of Iowa, Iowa City. IA52242, USA
Bruce Alexander
Affiliation:
University of Iowa, Iowa City. IA52242, USA
Randall A. Prince
Affiliation:
University of Iowa, Iowa City. IA52242, USA
Frederick J. Dunner
Affiliation:
University of Iowa, Iowa City. IA52242, USA
*
∗Correspondence
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Abstract

Two methods for predicting steady-state serum lithium level were compared prospectively in in-patients suffering from affective disorder. A single-point prospective administration model that required a single 24-hour serum lithium level, following a test dose produced statistically similar predictions of the observed steady-state lithium levels as did a model that required 12- and 36-hour levels. However, the latter two-point method produced significantly more accurate predictions from clinical interpretation. Although the two-point approach is preferable, the single-point method is clinically acceptable if its limitations of accuracy are taken into consideration.

Type
Papers
Information
The British Journal of Psychiatry , Volume 148 , Issue 4 , April 1986 , pp. 401 - 405
Copyright
Copyright © 1986 The Royal College of Psychiatrists 

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