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Undifferentiated dementia, Alzheimer's disease and vascular dementia: Age- and gender-related incidence in Liverpool: The MRC–ALPHA Study

  • J. R. M. Copeland (a1), Cherie McCracken (a1), M. E. Dewey (a2), K. C. M. Wilson (a3), Mark Doran (a4), Chris Gilmore (a5), Anne Scott (a6) and Bernie Larkin (a7)...

Abstract

Background

Does incidence of dementia follow the age pattern of prevalence? Is gender a risk factor? Do patterns of incidence differ between dementias?

Aims

To assess age-specific incidence rates of undifferentiated dementias, Alzheimer's disease and vascular dementia.

Method

5222 individuals aged $65 years, were interviewed using the Geriatric Mental State/History and Aetiology Schedule. The AGECAT package was used to identify cases at three interviewing waves at two-year intervals. Diagnoses were made using ICD −10 Research Criteria and validated against neurological and psychological examination, with imaging and neuropathology on unselected subsamples.

Results

Incidence rates of the dementias increase with age. Age patterns are similar between Alzheimer's disease and vascular dementia. Gender appears influential in Alzheimer's disease. In England and Wales, 39 437 new cases of Alzheimer's disease (4.9/1000 person-years at risk); 20 513 of vascular dementia (2.6/1000 person-years) and 155 169 of undifferentiated dementia (19/1000 person-years) can be expected each year.

Conclusions

Incidence rates for Alzheimer's disease and vascular dementia appear to behave differently with an increased risk of Alzheimer's disease for women compared to vascular dementia.

Copyright

Corresponding author

Professor J. R. M. Copeland, Department of Psychiatry, University of Liverpool, Royal Liverpool University Hospital, Liverpool L69 3GA

Footnotes

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Declaration of interest

Funding was received from the Medical Research Council (UK), Lilly Industries and the Human Ageing Trust.

Footnotes

References

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Undifferentiated dementia, Alzheimer's disease and vascular dementia: Age- and gender-related incidence in Liverpool: The MRC–ALPHA Study

  • J. R. M. Copeland (a1), Cherie McCracken (a1), M. E. Dewey (a2), K. C. M. Wilson (a3), Mark Doran (a4), Chris Gilmore (a5), Anne Scott (a6) and Bernie Larkin (a7)...

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Undifferentiated dementia, Alzheimer's disease and vascular dementia: Age- and gender-related incidence in Liverpool: The MRC–ALPHA Study

  • J. R. M. Copeland (a1), Cherie McCracken (a1), M. E. Dewey (a2), K. C. M. Wilson (a3), Mark Doran (a4), Chris Gilmore (a5), Anne Scott (a6) and Bernie Larkin (a7)...
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