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Third ventricle enlargement and developmental delay in first-episode psychosis: preliminary findings

  • Dominic Fannon (a1), Lakshika Tennakoon (a1), Alex Sumich (a1), Seamus O'Ceallaigh (a1), Victor Doku (a1), Xavier Chitnis (a1), Jennifer Lowe (a1), William Soni (a1) and Tonmoy Sharma (a1)...

Extract

Background

Third rather than lateral ventriculomegaly may be a more specific finding in psychosis. The relevance of ventricular abnormality remains unclear.

Aims

To investigate the developmental correlates of ventricular enlargement.

Method

Information on childhood development and magnetic resonance images in 1.5-mm contiguous sections were collected on 21 patients experiencing a first episode of psychosis.

Results

Patients (n=21) had significantly less whole brain volume and enlarged third and lateral ventricles compared to controls (n=25). Third ventricle (r=0.48, P < 0.03) and lateral ventricle (r=0.65, P < 0.01) volumes correlated with developmental score. Patients with developmental delay had significantly larger third and lateral ventricles than those without.

Conclusions

Enlargement of both third and lateral ventricles is found in first-episode psychosis and is related to developmental delay in childhood. Insult to periventricular areas is relevant to the neurobiology of the disease. These findings support the view that schizophrenia involves disturbance of neurodevelopmental processes in some patients.

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Copyright

Corresponding author

Dr Dominic Fannon, Department of Psychiatry, Institute of Psychiatry, Denmark Hill, London SE5 8AF, UK. Tel: 020 7919 2066; fax: 020 7252 3172; e-mail: d.fannon@iop.kcl.ac.uk

Footnotes

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Declaration of interest

Financially supported by Grosvenor House Group Estates and Psychmed Ltd.

Footnotes

References

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American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders (4th edn) (DSM–IV). Washington, DC: APA.
Andreasen, N. C., Olsen, S. A., Dennert, J. W., et al (1982) Ventricular enlargement in schizophrenia: relationship to positive and negative symptoms. American Journal of Psychiatry, 139, 297302.
Andreasen, N. C., Arndt, S., Swayze, V., et al (1994a) Thalamic abnormalities in schizophrenia visualized through magnetic resonance image averaging. Science, 266, 294298.
Andreasen, N. C., Flashman, L., Flaum, M., et al (1994b) Regional brain abnormalities in schizophrenia measured with magnetic resonance imaging. Journal of the American Medical Association, 272, 17631769.
Barta, P. E., Dhingra, L., Royall, R., et al (1997) Improving stereological estimates for the volume of structures identified in three-dimensional arrays of spatial data. Journal of Neuroscience Methods, 75, 111118.
Bilder, R. M., Wu, H., Bogerts, B., et al (1994) Absence of regional hemispheric volume asymmetries in first-episode schizophrenia. American Journal of Psychiatry, 151, 14371447
Bornstein, R. A., Schwartzkopf, S. B., Olson, S. C., et al (1992) Third ventricular enlargement and neuropsychological deficit in schizophrenia. Biological Psychiatry, 31, 954961.
Bullmore, E. T., Frangou, S. & Murray, R. M. (1997) The dysplastic net hypothesis: an integration of developmental and dysconnectivity theories of schizophrenia. Schizophrenia Research, 28, 143156.
Cannon, T. D., Fuhrmann, M., Mednick, S. A., et al (1988) Third ventricular enlargement and electrodermal responsiveness. Psychophysiology, 25, 153156.
Caputo, A., Ghiringhelli, L., Dieci, M., et al (1998) Epithalamus calcifications in schizophrenia. European Archives of Psychiatry: Clinical Neuroscience, 24, 272276.
Cowell, C., Turetsky, B. T., Gur, R. C., et al (1994) Sex differences in ageing of the human frontal and temporal lobe. Journal of Neurosciences, 14, 47484755.
Davis, J. O. & Bracha, H. S. (1996) Prenatal growth markers in schizophrenia: a monozygotic co-twin control study. American Journal of Psychiatry, 153, 11661172.
Dykes, K. L., Mednick, S. A., Machon, R. A., et al (1992) Adult third ventricle width and infant behavioural arousal in groups at high and low risk for schizophrenia. Schizophrenia Research, 7, 1318.
Frith, C. D., Stevens, M., Johnstone, E. C., (1979) Skin conductance responsivity during acute episodes of schizophrenia as a predictor of symptomatic improvement. Psychological Medicine, 9, 101106.
Harrison, P. J. (1999) The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain, 122, 593624.
Jones, P., Rogers, B., Murray, R., et al (1994a) Child development risk factors for adult schizophrenia in the British 1946 birth cohort. Lancet, 344, 13981402.
Jones, P., Harvey, I., Lewis, S. W., et al (1994b) Cerebral ventricle dimensions as risk factors for schizophrenia and affective psychosis: an epidemiological approach to analysis. Psychological Medicine, 24, 9951011.
Kay, S. R., Fiszbein, A. & Opier, L. A. (1987) The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophrenia Bulletin, 13, 261276.
Keshavan, M. S., Montrose, D. M., Pierri, J. N., et al (1997) Magnetic resonance imaging and spectroscopy in offspring at risk for schizophrenia: preliminary studies. Progress in Neuro-psychopharmacology and Biological Psychiatry, 21, 12851295.
Lane, A., Kinsella, A., Murphy, P., et al (1997) The anthropometric assessment of dysmorphic features in schizophrenia as an index of its developmental origins. Psychological Medicine, 27, 11551164.
McCarley, R. W., Wible, C. G., Frumin, M., et al (1999) MRI anatomy of schizophrenia. Biological Psychiatry, 45, 10991119.
Murray, R. M. & Lewis, S. W. (1987) Is schizophrenia a neurodevelopmental disorder? British Medical Journal, 295, 681682.
Murray, R. M. O'Callaghan, E. & Castle, D. J. (1992) A neurodevelopmental approach to the classification of schizophrenia. Schizophrenia Bulletin, 18, 319332.
Office of Population Censuses and Surveys (1991) Classification of Occupations & Classification of Ethnicity. London: HMSO.
Oldfield, R. C. (1971) The assessment and analysis of handedness: the Edinburgh Inventory. Neuropsychologia, 9, 97114.
Paus, P., Zijdenbos, A., Worsley, K., et al (1999) Structural maturation of neural pathways in children and adolescents: in vivo study. Science, 283, 19081911.
Sharma, T., Deboulay, G. & Lewis, S. (1997) The Maudsley Family Study I. Structural brain changes on magnetic resonance imaging in familial schizophrenia. Progress in Neuro-psychopharmacology and Biological Psychiatry, 21, 12971315.
Sheline, Y. I., Sanghavi, M., Mintun, M. A., et al (1999) Depression duration but not age predicts hippocampal volume loss in medically healthy women with recurrent major depression. Journal of Neuroscience, 19, 50345043.
Snyder, P. J., Bogerts, B. & Wu, H. (1998) Absence of the adhesio interthalamica as a marker of early development neuropathology in schizophrenia: an MRI and postmortem histologic study. Journal of Neuroimaging, 8, 159163.
Spitzer, R. L., Williams, J. B., Gibbon, M., et al (1990) Structured Clinical Interview for DSM–III–R, Patient Edition. Washington, DC: American Psychiatric Press.
Tibbo, P., Nopoulos, P., Arndt, S., et al (1998) Corpus callosum shape and size in male patients with schizophrenia. Biological Psychiatry, 44, 405412.

Third ventricle enlargement and developmental delay in first-episode psychosis: preliminary findings

  • Dominic Fannon (a1), Lakshika Tennakoon (a1), Alex Sumich (a1), Seamus O'Ceallaigh (a1), Victor Doku (a1), Xavier Chitnis (a1), Jennifer Lowe (a1), William Soni (a1) and Tonmoy Sharma (a1)...

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Third ventricle enlargement and developmental delay in first-episode psychosis: preliminary findings

  • Dominic Fannon (a1), Lakshika Tennakoon (a1), Alex Sumich (a1), Seamus O'Ceallaigh (a1), Victor Doku (a1), Xavier Chitnis (a1), Jennifer Lowe (a1), William Soni (a1) and Tonmoy Sharma (a1)...
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