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SPET study of verbal fluency in schizophrenia and epilepsy

  • John D. C. Mellers (a1), Naoto Adachi (a2), Noriyoshi Takei (a3), Alice Cluckie (a4), Brian K. Toone (a2) and W. Alwyn Lishman (a5)...

Abstract

Background

The association between temporal lobe epilepsy and schizophrenia suggests that the critical abnormality may be pathology within the temporal lobes. People with schizophrenia-like psychosis of epilepsy (SLPE) provide a useful group in which to examine the importance of temporal and frontal lobe dysfunction in schizophrenia.

Method

A verbal fluency activation paradigm and a 99mTc HMPAO SPET were used to study frontotemporal function in people with SLPE (n = 12), schizophrenia (n = 11) and epilepsy (n = 16).

Results

People with SLPE differed from both other groups by showing lower blood flow in the left superior temporal gyrus during performance of a verbal fluency task compared with a word repetition task (F=5.4, P=0.01). During the verbal fluency task people with primary schizophrenia showed a greater increase in blood flow in anterior cingulate (F=4.5, P=0.02) than the other two groups. There were no between-group differences in frontal brain regions.

Conclusion

Our findings support an association between left temporal lobe abnormality and SLPE. The different patterns of activation observed in people with primary schizophrenia and SLPE suggests that different pathophysiological mechanisms may operate in these two groups. In SLPE the pathophysiology may be relatively confined to the dominant temporal lobe.

Copyright

Corresponding author

Dr J. D. C. Meilers, Department of Neuropsychiatry, Maudsley Hospital, Denmark Hill, London SE5 8AZ

References

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American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised) (DSM—III—R). Washington, DC: APA.
Chua, S. E. & McKenna, P. J. (1995) Schizophrenia — a brain disease? A critical review of structural and functional cerebral abnormality in the disorder. British Journal of Psychiatry, 166, 563582.
Devous, M. D. Leroy, R. F. & Homan, R. W. (1990) Single photon emission computed tomography in epilepsy. Seminars in Nuclear Medicine, 20, 325341.
Dolan, R. J. Fletcher, P. Frith, C. D. et al (1995) Dopaminergic modulation of impaired cognitive activation in the anterior cingulate cortex in schizophrenia. Nature, 378, 180182.
Flor-Henry, P. (1969) Psychosis and temporal lobe epilepsy: a controlled investigation. Epilepsia, 10, 363369.
Frith, C. D. Friston, K. J. Herald, S. et al (1995) Regional brain activity in chronic schizophrenic patients during the performance of a verbal fluency task. British Journal of Psychiatry, 167, 343349.
Gunn, J. & Fenton, G. W. (1969) Epilepsy in prisons: a diagnostic survey. British Medical Journal, iv, 326328.
Kawasaki, Y. Maeda, Y. Suzuki, M. et al (1993) SPECT analysis of regional cerebral blood flow changes in patients with schizophrenia during the Wisconsin Card Sorting Test. Schizophrenia Research, 10, 109116.
Kristensen, O. & Sindrup, E. H. (1978) Psychomotor epilepsy and psychosis. 11. Electroencephalographic findings. Acta Neurologica Scandinavica, 57, 370379.
Marshall, E. J. Syed, G. M. S. Fenwick, P. B. C. et al (1993) A pilot study of schizophrenia-like psychosis in epilepsy using single photon emission computerised tomography. British Journal of Psychiatry, 163, 3236.
Mendel, M. F. Grau, R. Doss, R. C. et al (1993) Schizophrenia in epilepsy: seizure and psychosis variables. Neurology, 43, 10731077.
Nelson, H. E. (1982) The National Adult Reading Test Manual. Windsor: NFER-Nelson.
Overall, J. E. & Gorham, D. R. (1962) The Brief Psychiatric Rating Scale. Psychological Research, 10, 799812.
Ron, M. A. & Harvey, I. (1990) The brain in schizophrenia. Journal of Neurology, Neurosurgery and Psychiatry, 53, 725726.
Schoneil, F. (1942) Backwardness in the Basic Subjects. London: Oliver and Boyd.
Shedlack, K. J. Hunter, R. Wyper, D. et al (1991) The pattern of cerebral activity underlying verbal fluency as shown by split-dose single photon emission tomography (SPETor SPECT) in normal volunteers. Psychological Medicine, 21, 687696.
Talairach, J. & Tournoux, P. (1988) A Coplanar Stereotactic Atlas of Human Brain. Stuttgart: Thieme Verlag.
Toone, B. K. Dawson, J. & Driver, M. V. (1982) Psychoses of epilepsy: A radiological evaluation. British Journal of Psychiatry, 140, 244248.
Warburton, E. Wise, R. J. S. Price, C. J. et al (1996) Noun and verb retrieval by normal subjects. Studies with PET. Brain, 119, 159179.
Weinberger, D. R. Berman, K. F. Suddath, R. et al (1992) Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: a magnetic resonance imaging and regional cerebral blood flow study of discordant monozygotic twins. American Journal of Psychiatry, 149, 890897.

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SPET study of verbal fluency in schizophrenia and epilepsy

  • John D. C. Mellers (a1), Naoto Adachi (a2), Noriyoshi Takei (a3), Alice Cluckie (a4), Brian K. Toone (a2) and W. Alwyn Lishman (a5)...
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