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Sensorimotor Cortex and Supplementary Motor Area Changes in Schizophrenia: A Study with Functional Magnetic Resonance Imaging

  • J. Schröder (a1), F. Wenz (a2), L. R. Schad (a3), K. Baudendistel (a3) and M. V. Knopp (a3)...

Abstract

Background

Neurological soft signs (NSS) such as a disturbed finger-to-thumb opposition are frequently found in schizophrenia. To identify the underlying cerebral changes we investigated sensorimotor cortex and supplementary motor area (SMA) activation during finger-to-thumb opposition using functional magnetic resonance imaging (fMRI).

Method

Ten DSM–III–R schizophrenics and seven healthy controls were included. All subjects were right-handed. fMRI was carried out in a resting condition followed by an activation state (finger-to-thumb opposition) and the activities in the sensorimotor cortices and SMA recorded.

Results

All subjects showed a significant activation of the SMA and both ipsilateral and contralateral sensorimotor cortices. In the controls, ipsilateral finger-to-thumb opposition was associated with a greater left than right hemispheric sensorimotor cortex coactivation. When compared with the healthy controls, the schizophrenic patients showed a decreased activation of both sensorimotor cortices and SMA, as well as a reversed lateralisation effect.

Conclusion

Sensorimotor cortex and SMA dysfunction are associated with motor disturbances in schizophrenia.

Copyright

Corresponding author

Dr Schröder, Department of Psychiatry, Voß-Strasse 4, 69115 Heidelberg, FRG. Fax: (06 221) 563477

References

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Sensorimotor Cortex and Supplementary Motor Area Changes in Schizophrenia: A Study with Functional Magnetic Resonance Imaging

  • J. Schröder (a1), F. Wenz (a2), L. R. Schad (a3), K. Baudendistel (a3) and M. V. Knopp (a3)...

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Sensorimotor Cortex and Supplementary Motor Area Changes in Schizophrenia: A Study with Functional Magnetic Resonance Imaging

  • J. Schröder (a1), F. Wenz (a2), L. R. Schad (a3), K. Baudendistel (a3) and M. V. Knopp (a3)...
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