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Role played by the SP4 gene in schizophrenia and major depressive disorder in the Han Chinese population

  • Jianhua Chen (a1), Kuanjun He (a2), Qingzhong Wang (a2), Zhiqiang Li (a2), Jiawei Shen (a2), Tao Li (a2), Meng Wang (a2), Zujia Wen (a2), Wenjin Li (a2), Yu Qiang (a2), Ti Wang (a2), Jue Ji (a2), Na Wu (a2), Zhiqiao Wang (a2), Bo Zhang (a2), Guoyin Feng (a3), Lin He (a2), Yifeng Xu (a3) and Yongyong Shi (a4)...

Abstract

Background

Psychiatric disorders such as schizophrenia and major depressive disorder (MDD) are likely to be caused by multiple susceptibility genes, each with small effects in increasing the risk of illness. Identifying DNA variants associated with schizophrenia and MDD is a crucial step in understanding the pathophysiology of these disorders.

Aims

To investigate whether the SP4 gene plays a significant role in schizophrenia or MDD in the Han Chinese population.

Method

We focused on nine single nucleotide polymorphisms (SNPs) harbouring the SP4 gene and carried out case–control studies in 1235 patients with schizophrenia, 1045 patients with MDD and 1235 healthy controls recruited from the Han Chinese population.

Results

We found that rs40245 was significantly associated with schizophrenia in both allele and genotype distributions (P allele = 0.0005, P allele = 0.004 after Bonferroni correction; P genotype = 0.0023, P genotype = 0.0184 after Bonferroni correction). The rs6461563 SNP was significantly associated with schizophrenia in the allele distributions (P allele = 0.0033, P allele = 0.0264 after Bonferroni correction).

Conclusions

Our results suggest that common risk factors in the SP4 gene are associated with schizophrenia, although not with MDD, in the Han Chinese population.

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Copyright

Corresponding author

Yongyong Shi, Bio-X Institutes, Shanghai Jiao Tong University, Central Little White House, 1954 Huashan Road, Shanghai 200030, China. Email: shiyongyong@gmail.com; Yifeng Xu, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai 200030, China. Email: hyyyyb@gmail.com

Footnotes

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Declaration of interest

None.

Footnotes

References

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Role played by the SP4 gene in schizophrenia and major depressive disorder in the Han Chinese population

  • Jianhua Chen (a1), Kuanjun He (a2), Qingzhong Wang (a2), Zhiqiang Li (a2), Jiawei Shen (a2), Tao Li (a2), Meng Wang (a2), Zujia Wen (a2), Wenjin Li (a2), Yu Qiang (a2), Ti Wang (a2), Jue Ji (a2), Na Wu (a2), Zhiqiao Wang (a2), Bo Zhang (a2), Guoyin Feng (a3), Lin He (a2), Yifeng Xu (a3) and Yongyong Shi (a4)...

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Role played by the SP4 gene in schizophrenia and major depressive disorder in the Han Chinese population

  • Jianhua Chen (a1), Kuanjun He (a2), Qingzhong Wang (a2), Zhiqiang Li (a2), Jiawei Shen (a2), Tao Li (a2), Meng Wang (a2), Zujia Wen (a2), Wenjin Li (a2), Yu Qiang (a2), Ti Wang (a2), Jue Ji (a2), Na Wu (a2), Zhiqiao Wang (a2), Bo Zhang (a2), Guoyin Feng (a3), Lin He (a2), Yifeng Xu (a3) and Yongyong Shi (a4)...
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