Hostname: page-component-78c5997874-lj6df Total loading time: 0 Render date: 2024-11-17T14:36:23.306Z Has data issue: false hasContentIssue false
  • English
  • Français

The Relationship between Wrist-Monitored Motor Activity and Serum CPK Activity in Psychiatric In-Patients

Published online by Cambridge University Press:  29 January 2018

David J. Goode ,
Herbert Y. Meltzer ,
Robert Moretti ,
David J. Kupfer  and
Richard J. McPartland
David J. Goode
Affiliation:
Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina 27103, Broughton State Hospital, Morganton, North Carolina
Herbert Y. Meltzer
Affiliation:
Pritzker School of Medicine, University of Chicago, 950 East 59th Street, Chicago, Illinois 60632, Laboratory of Biological Psychiatry, Illinois State Pyschiatric Institute, 1601 West Taylor Street, Chicago, Illinois 60612
Robert Moretti
Affiliation:
Illinois State Psychiatric Institute, 1601 West Taylor Street, Chicago, Illinois 60612
David J. Kupfer
Affiliation:
University of Pittsburgh School of Medicine, and Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Pittsburgh, Pennsylvania 15261
Richard J. McPartland
Affiliation:
University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, Pennsylvania 15261
Get access Rights & Permissions [Opens in a new window]

Summary

Motor activity, monitored by a wrist motion transducer, was related to serum CPK activity the following morning in a group of psychiatric in-patients. In 4 of 10 patients, studied for periods exceeding one week, total 24-hour activity was significantly correlated with morning serum CPK activity. Motor activity during the night was unrelated to serum CPK activity. In a larger group of 30 patients, studied for one or two-day periods, inter-individual differences in activity level were not related to serum CPK activity, although both sex and race were significantly related to variance between subjects in that activity.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 135 , Issue 1 , July 1979 , pp. 62 - 66
Copyright
Copyright © The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Ahlborg, B. & Brohult, J. (1966) Metabolic changes after exercise. Lancet, i, 1272.Google Scholar
Ahlborg, B. & Brohult, J. (1967) Immediate and delayed metabolic reactions in well trained subjects after prolonged physical exercise. Acta Medica Scandinavica, 182, 41–54.Google Scholar
Bauman, P., Escher, J. & Richterich, R. (1962) The behaviour of serum enzymes during exercise. Schweizerische Zeitschrift für Sportmedizin, 10, 33–51.Google Scholar
Bengzon, A., Hippius, H. & Konig, K. (1966) Some changes in the serum during treatment with psychotropic drugs. Journal of Nervous and Mental Disease, 143, 369–76.Google Scholar
Coffey, J. W., Heath, R. G. & Guschwan, A. F. (1970) Serum creatine kinase, aldolase, and copper in acute and chronic schizophrenics. Biological Psychiatry, 2, 331–9.Google Scholar
Cunningham, L. A., Rich, C. L., Woodruff, R. A. & Olney, J. W. (1974) Creatine phosphokinase and psychiatric illness. British Journal of Psychiatry, 124, 578, 87–91.Google Scholar
Goode, D. J. & Meltzer, H. Y. (1976) Effect of isometric exercise on serum creatine phosphokinase activity. Archives of General Psychiatry, 33, 1207–11.Google Scholar
Goode, D. J., Weinberg, D. H., Mazura, T. A., Curtiss, G., Moretti, R. J. & Meltzer, H. Y. (1977) Effect of limb restraints on serum creatine phosphokinase activity in normal volunteers. Biological Psychiatry, 12, 743–55.Google Scholar
Gosling, R., Kerry, R. J., Orme, J. E. & Owen, G. (1972) Creatine Phosphokinase activity in newly admitted psychiatric patients. British Journal of Psychiatry, 121, 351–5.Google Scholar
Gosling, R., Kerry, R. J. & Owen, G. (1972) Creatine phosphokinase activity during lithium treatment. British Medical Journal, 3, 327–9.Google Scholar
Griffiths, P. D. (1966) Serum levels of A. T. P. creatine phosphotransferase (creatine kinase): the normal range and effect of muscular activity. Clinica Chimica Acta, 13, 413–20.Google Scholar
Guterman, A. (1973) Manifest psychopathology and serum creatine phosphokinase: a correlational study. Diseases of the Nervous System, 34, 1, 49–53.Google Scholar
Harding, T. (1974) Serum creatine kinase in acute psychosis. British Journal of Psychiatry, 125, 280–5.Google Scholar
Ikeda, H. (1977) Serum creatine phosphokinase activity in newly admitted chronic alcoholics. Folia Psychiatrica et Neurologica Japonica, 31, 9–16.Google Scholar
Kupfer, D. J. & Foster, F. G. (1973) Sleep and activity in a psychotic depression. Journal of Nervous and Mental Disease, 156, 5, 341–8.Google Scholar
Meltzer, H. Y. (1969) Intramuscular chlorpromazine and creatine kinase: acute psychoses or local muscle trauma. Science, 164, 726–7.Google Scholar
Meltzer, H. Y. (1969) Muscle enzyme release in the acute psychoses. Archives of General Psychiatry, 21, 102–12.Google Scholar
Meltzer, H. Y. (1975) Neuromuscular abnormalities in the major mental illnesses. I. Serum enzyme studies. The Biology of the Major Psychoses: A Comparative Analysis (ed. Freedman, D. X.). N.Y.: Raven Press.Google Scholar
Meltzer, H. Y. & Holy, P. A. (1974) Black-white differences in serum creatine phosphokinase (CPK) activity. Clinica Chimica Acta, 54, 215–24.Google Scholar
Meltzer, H. Y. & Moline, R. (1970) Plasma enzymatic activity after exercise: study of psychiatric patients and their relatives. Archives of General Psychiatry, 22, 390–7.Google Scholar
Nuttal, F. Q. & Jones, B. (1968) Creatine kinase and glutamic oxalacetic transaminase activity in serum: kinetics of change with exercise and effect of physical conditioning. Journal of Laboratory and Clinical Medicine, 71, 847–54.Google Scholar
Rasch, P. J. & Schwartz, P. L. (1972) Effect of amateur wrestling on selected serum enzymes. Journal of Sports Medicine, 12, 82–6.Google Scholar
Rosalki, S. B. (1967) An improved procedure for serum creatine phosphokinase determination. Journal of Laboratory and Clinical Medicine, 69, 696–705.Google Scholar
Schweid, D. E., Steinberg, J. S. & Sudak, H. S. (1972) Creatine phosphokinase and psychosis. Archives of General Psychiatry, 26, 263–5.Google Scholar
Soni, S. D. (1976) Serum creatine phosphokinase in acute psychosis. British Journal of Psychiatry, 128, 181–3.Google Scholar
Tropeano, G., Cocorullo, M., Del Vecchio, M., Amati, A. & Kemali, D. (1972) Comportamento del livelli serici di CPK e aldolasi in pazienti psyichiatrici. Acta Neurologica, (Napoli) 27, 386–94.Google Scholar
Warnock, D. G. & Ellman, G. L. (1969) Intramuscular chlorpromazine and creatine kinase: acute psychoses or local muscle trauma ? Science, 164, 726.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.